IRS1

 

Full name: insulin receptor substrate 1 Alias Symbol: HIRS-1
Type: protein-coding gene Cytoband: 2q36.3
Entrez ID: 3667 HGNC ID: HGNC:6125 Ensembl Gene: ENSG00000169047 OMIM ID: 147545
Drug and gene relationship at DGIdb
Screen Evidence:

 

IRS1 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04068FoxO signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04960Aldosterone-regulated sodium reabsorption

 

Expression of IRS1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IRS1 3667 204686_at -0.3509 0.8340
GSE20347 IRS1 3667 204686_at 1.4718 0.0000
GSE23400 IRS1 3667 204686_at 1.2468 0.0000
GSE26886 IRS1 3667 204686_at 2.3638 0.0000
GSE29001 IRS1 3667 204686_at 1.2858 0.0214
GSE38129 IRS1 3667 204686_at 1.0633 0.0000
GSE45670 IRS1 3667 204686_at 0.9410 0.0163
GSE53622 IRS1 3667 31936 1.0998 0.0000
GSE53624 IRS1 3667 31936 1.3615 0.0000
GSE63941 IRS1 3667 204686_at -1.8158 0.0267
GSE77861 IRS1 3667 204686_at 1.0618 0.0712
GSE97050 IRS1 3667 A_24_P225679 1.0630 0.1074
SRP007169 IRS1 3667 RNAseq 2.5553 0.0000
SRP008496 IRS1 3667 RNAseq 2.8356 0.0002
SRP064894 IRS1 3667 RNAseq 1.1293 0.0001
SRP133303 IRS1 3667 RNAseq 1.9688 0.0000
SRP159526 IRS1 3667 RNAseq 0.5018 0.0684
SRP193095 IRS1 3667 RNAseq 1.4089 0.0000
SRP219564 IRS1 3667 RNAseq 0.2196 0.7432
TCGA IRS1 3667 RNAseq -0.0679 0.4835

Upregulated datasets: 12; Downregulated datasets: 1.  

 

Survival by IRS1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IRS1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IRS1 3667 2 12 16
GSE20123 IRS1 3667 2 12 16
GSE43470 IRS1 3667 0 7 36
GSE46452 IRS1 3667 0 5 54
GSE47630 IRS1 3667 4 5 31
GSE54993 IRS1 3667 1 2 67
GSE54994 IRS1 3667 6 11 36
GSE60625 IRS1 3667 0 3 8
GSE74703 IRS1 3667 0 6 30
GSE74704 IRS1 3667 2 6 12
TCGA IRS1 3667 13 26 57

Total number of gains: 30; Total number of losses: 95; Total Number of normals: 363.  

 

Somatic mutations of IRS1:

 

Generating mutation plots.

 

Highly correlated genes for IRS1:

 

Showing top 20/1120 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IRS1PET1170.736482303
IRS1SLC39A140.72800711011
IRS1KLF70.72431212011
IRS1ITGA30.71452210010
IRS1SH3PXD2B0.714331606
IRS1ENAH0.71398111011
IRS1TMEM184B0.71396810010
IRS1FMNL20.713552707
IRS1INHBA0.71328111010
IRS1PXN0.71289710010
IRS1LOXL20.71141711011
IRS1LPCAT10.7100381009
IRS1LGALS80.707193303
IRS1PPP1R210.704226303
IRS1FBLIM10.700939706
IRS1TRADD0.699501303
IRS1CCM20.697992606
IRS1ARPC1B0.69589510010
IRS1TGFBI0.69545613013
IRS1XPR10.695161606

For details and further investigation, click here