PLCG2

 

Full name: phospholipase C gamma 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 16q24.1
Entrez ID: 5336 HGNC ID: HGNC:9066 Ensembl Gene:  OMIM ID: 600220
Drug and gene relationship at DGIdb

 

PLCG2 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04020Calcium signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04066HIF-1 signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04611Platelet activation
hsa04650Natural killer cell mediated cytotoxicity
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04750Inflammatory mediator regulation of TRP channels
hsa04919Thyroid hormone signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05110Vibrio cholerae infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05214Glioma
hsa05223Non-small cell lung cancer

 

Expression of PLCG2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLCG2 5336 204613_at 0.5504 0.3955
GSE20347 PLCG2 5336 204613_at 0.5557 0.0002
GSE23400 PLCG2 5336 204613_at 0.1577 0.0095
GSE26886 PLCG2 5336 204613_at -0.0610 0.7589
GSE29001 PLCG2 5336 204613_at 0.5426 0.0190
GSE38129 PLCG2 5336 204613_at 0.4427 0.0450
GSE45670 PLCG2 5336 204613_at 0.3176 0.1770
GSE53622 PLCG2 5336 54138 0.2362 0.0088
GSE53624 PLCG2 5336 54138 0.1485 0.0674
GSE63941 PLCG2 5336 204613_at 2.1288 0.0035
GSE77861 PLCG2 5336 204613_at 0.6239 0.0066
GSE97050 PLCG2 5336 A_23_P106675 0.6254 0.1932
SRP007169 PLCG2 5336 RNAseq 0.2421 0.5228
SRP008496 PLCG2 5336 RNAseq 0.6536 0.0281
SRP064894 PLCG2 5336 RNAseq 0.6551 0.0017
SRP133303 PLCG2 5336 RNAseq 0.0144 0.9497
SRP159526 PLCG2 5336 RNAseq -0.4967 0.4116
SRP193095 PLCG2 5336 RNAseq 0.4658 0.0813
SRP219564 PLCG2 5336 RNAseq 0.5383 0.0218
TCGA PLCG2 5336 RNAseq 0.0378 0.6911

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PLCG2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLCG2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLCG2 5336 5 4 21
GSE20123 PLCG2 5336 5 4 21
GSE43470 PLCG2 5336 2 8 33
GSE46452 PLCG2 5336 37 2 20
GSE47630 PLCG2 5336 11 9 20
GSE54993 PLCG2 5336 2 4 64
GSE54994 PLCG2 5336 7 10 36
GSE60625 PLCG2 5336 4 0 7
GSE74703 PLCG2 5336 2 6 28
GSE74704 PLCG2 5336 3 3 14
TCGA PLCG2 5336 26 16 54

Total number of gains: 104; Total number of losses: 66; Total Number of normals: 318.  

 

Somatic mutations of PLCG2:

 

Generating mutation plots.

 

Highly correlated genes for PLCG2:

 

Showing top 20/350 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLCG2UHRF10.733455303
PLCG2TRAT10.714725303
PLCG2PPP1R14C0.7075404
PLCG2B4GALNT30.706903303
PLCG2FAM192A0.70456303
PLCG2SDK10.692881303
PLCG2MCM70.692162403
PLCG2DVL20.690442303
PLCG2RANBP10.685539303
PLCG2MUS810.682735303
PLCG2IRX20.681009303
PLCG2CPNE20.679981303
PLCG2TIGIT0.679944303
PLCG2ERAL10.677277303
PLCG2TMC80.673623504
PLCG2HOXD110.671217404
PLCG2LILRB10.668294404
PLCG2PLEKHG4B0.667168303
PLCG2SAC3D10.659318403
PLCG2FCRL50.656998404

For details and further investigation, click here