ISG15

 

Full name: ISG15 ubiquitin like modifier Alias Symbol: IFI15|UCRP
Type: protein-coding gene Cytoband: 1p36.33
Entrez ID: 9636 HGNC ID: HGNC:4053 Ensembl Gene: ENSG00000187608 OMIM ID: 147571
Drug and gene relationship at DGIdb
Screen Evidence:

 

ISG15 involved pathways:

KEGG pathway Description View
hsa04622RIG-I-like receptor signaling pathway

 

Expression of ISG15:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ISG15 9636 205483_s_at 1.4499 0.2511
GSE20347 ISG15 9636 205483_s_at 2.8021 0.0000
GSE23400 ISG15 9636 205483_s_at 2.1187 0.0000
GSE26886 ISG15 9636 205483_s_at 2.7214 0.0000
GSE29001 ISG15 9636 205483_s_at 2.7620 0.0001
GSE38129 ISG15 9636 205483_s_at 2.3173 0.0000
GSE45670 ISG15 9636 205483_s_at 3.3148 0.0000
GSE53622 ISG15 9636 19519 1.6805 0.0000
GSE53624 ISG15 9636 19519 2.2377 0.0000
GSE63941 ISG15 9636 205483_s_at -1.1231 0.3939
GSE77861 ISG15 9636 205483_s_at 1.7945 0.0086
GSE97050 ISG15 9636 A_23_P819 0.7257 0.2433
SRP007169 ISG15 9636 RNAseq 1.6743 0.0097
SRP008496 ISG15 9636 RNAseq 1.6363 0.0004
SRP064894 ISG15 9636 RNAseq 2.6564 0.0000
SRP133303 ISG15 9636 RNAseq 2.3024 0.0000
SRP193095 ISG15 9636 RNAseq 2.0278 0.0000
SRP219564 ISG15 9636 RNAseq 0.8086 0.3886
TCGA ISG15 9636 RNAseq 0.9203 0.0000

Upregulated datasets: 14; Downregulated datasets: 0.  

 

Survival by ISG15 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ISG15:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ISG15 9636 3 7 20
GSE20123 ISG15 9636 3 6 21
GSE43470 ISG15 9636 1 5 37
GSE46452 ISG15 9636 7 1 51
GSE47630 ISG15 9636 8 4 28
GSE54993 ISG15 9636 2 2 66
GSE54994 ISG15 9636 15 2 36
GSE60625 ISG15 9636 0 0 11
GSE74703 ISG15 9636 1 3 32
GSE74704 ISG15 9636 3 0 17
TCGA ISG15 9636 14 20 62

Total number of gains: 57; Total number of losses: 50; Total Number of normals: 381.  

 

Somatic mutations of ISG15:

 

Generating mutation plots.

 

Highly correlated genes for ISG15:

 

Showing top 20/1130 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ISG15IFI60.86850413013
ISG15USP410.794857303
ISG15IFIT10.79366512012
ISG15IFIT30.78087813012
ISG15IFI440.77968613013
ISG15PARP120.77243613013
ISG15IFI350.76776513012
ISG15DDX600.76429613012
ISG15RSAD20.75285913012
ISG15ADAR0.73809211010
ISG15IFI44L0.73656613011
ISG15UBE2L60.73401113011
ISG15LAMP30.72785912012
ISG15STAT10.72619713013
ISG15HERC50.72338112011
ISG15OAS20.7204912010
ISG15COL1A10.7200381009
ISG15MMP10.71256711010
ISG15ARPC1B0.71160210010
ISG15NT5C3A0.710436404

For details and further investigation, click here