OAS2

 

Full name: 2'-5'-oligoadenylate synthetase 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 12q24.13
Entrez ID: 4939 HGNC ID: HGNC:8087 Ensembl Gene: ENSG00000111335 OMIM ID: 603350
Drug and gene relationship at DGIdb

 

OAS2 involved pathways:

KEGG pathway Description View
hsa05164Influenza A
hsa05168Herpes simplex infection

 

Expression of OAS2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 OAS2 4939 204972_at 0.5139 0.5954
GSE20347 OAS2 4939 204972_at 0.7476 0.0176
GSE23400 OAS2 4939 204972_at 0.6744 0.0000
GSE26886 OAS2 4939 204972_at -0.3703 0.5221
GSE29001 OAS2 4939 204972_at 1.3218 0.0004
GSE38129 OAS2 4939 204972_at 0.8313 0.0038
GSE45670 OAS2 4939 204972_at 2.2768 0.0000
GSE53622 OAS2 4939 80154 1.2538 0.0000
GSE53624 OAS2 4939 80154 1.3559 0.0000
GSE63941 OAS2 4939 206553_at 0.0871 0.9236
GSE77861 OAS2 4939 204972_at 0.2660 0.5773
GSE97050 OAS2 4939 A_33_P3225512 0.9654 0.2237
SRP007169 OAS2 4939 RNAseq 2.2327 0.0002
SRP008496 OAS2 4939 RNAseq 1.4918 0.0011
SRP064894 OAS2 4939 RNAseq 1.9412 0.0000
SRP133303 OAS2 4939 RNAseq 0.9101 0.0067
SRP159526 OAS2 4939 RNAseq -0.7032 0.3650
SRP193095 OAS2 4939 RNAseq 1.1419 0.0000
TCGA OAS2 4939 RNAseq 0.5042 0.0000

Upregulated datasets: 8; Downregulated datasets: 0.  

 

Survival by OAS2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of OAS2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 OAS2 4939 4 3 23
GSE20123 OAS2 4939 4 3 23
GSE43470 OAS2 4939 2 0 41
GSE46452 OAS2 4939 9 1 49
GSE47630 OAS2 4939 9 3 28
GSE54993 OAS2 4939 0 5 65
GSE54994 OAS2 4939 4 2 47
GSE60625 OAS2 4939 0 0 11
GSE74703 OAS2 4939 2 0 34
GSE74704 OAS2 4939 2 2 16
TCGA OAS2 4939 22 11 63

Total number of gains: 58; Total number of losses: 30; Total Number of normals: 400.  

 

Somatic mutations of OAS2:

 

Generating mutation plots.

 

Highly correlated genes for OAS2:

 

Showing top 20/495 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
OAS2MX10.8128711011
OAS2RNF2130.79853404
OAS2USP410.792535303
OAS2RSAD20.78498612012
OAS2EPSTI10.779021707
OAS2IFI440.77273313012
OAS2OAS30.76787413012
OAS2IFI60.75637211011
OAS2PARP90.747394808
OAS2IFI44L0.73503613012
OAS2DDX600.72903913011
OAS2CMPK20.723305807
OAS2IFIT30.72157513012
OAS2STAT10.72099412011
OAS2ISG150.7204912010
OAS2UBE2L60.71998612011
OAS2IFIT10.71627213012
OAS2PARP120.71572312011
OAS2BST20.70753912011
OAS2APBB1IP0.705041303

For details and further investigation, click here