| Full name: HECT and RLD domain containing E3 ubiquitin protein ligase 5 | Alias Symbol: CEB1 | ||
| Type: protein-coding gene | Cytoband: 4q22.1 | ||
| Entrez ID: 51191 | HGNC ID: HGNC:24368 | Ensembl Gene: ENSG00000138646 | OMIM ID: 608242 |
| Drug and gene relationship at DGIdb | |||
Expression of HERC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HERC5 | 51191 | 219863_at | 1.1984 | 0.1930 | |
| GSE20347 | HERC5 | 51191 | 219863_at | 1.6650 | 0.0000 | |
| GSE23400 | HERC5 | 51191 | 219863_at | 0.6155 | 0.0000 | |
| GSE26886 | HERC5 | 51191 | 219863_at | 2.6672 | 0.0000 | |
| GSE29001 | HERC5 | 51191 | 219863_at | 1.9741 | 0.0001 | |
| GSE38129 | HERC5 | 51191 | 219863_at | 1.3747 | 0.0000 | |
| GSE45670 | HERC5 | 51191 | 219863_at | 0.9772 | 0.0326 | |
| GSE53622 | HERC5 | 51191 | 52272 | 1.0374 | 0.0000 | |
| GSE53624 | HERC5 | 51191 | 52272 | 1.4814 | 0.0000 | |
| GSE63941 | HERC5 | 51191 | 219863_at | 0.9417 | 0.5012 | |
| GSE77861 | HERC5 | 51191 | 219863_at | 0.3649 | 0.4302 | |
| GSE97050 | HERC5 | 51191 | A_23_P110196 | 0.2850 | 0.3671 | |
| SRP007169 | HERC5 | 51191 | RNAseq | 4.8161 | 0.0000 | |
| SRP064894 | HERC5 | 51191 | RNAseq | 1.3087 | 0.0000 | |
| SRP133303 | HERC5 | 51191 | RNAseq | 0.7436 | 0.0019 | |
| SRP159526 | HERC5 | 51191 | RNAseq | 1.0652 | 0.0022 | |
| SRP193095 | HERC5 | 51191 | RNAseq | 1.3882 | 0.0000 | |
| SRP219564 | HERC5 | 51191 | RNAseq | 0.8104 | 0.0873 | |
| TCGA | HERC5 | 51191 | RNAseq | 0.2776 | 0.0525 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by HERC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HERC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HERC5 | 51191 | 2 | 12 | 16 | |
| GSE20123 | HERC5 | 51191 | 2 | 12 | 16 | |
| GSE43470 | HERC5 | 51191 | 0 | 13 | 30 | |
| GSE46452 | HERC5 | 51191 | 1 | 36 | 22 | |
| GSE47630 | HERC5 | 51191 | 0 | 20 | 20 | |
| GSE54993 | HERC5 | 51191 | 8 | 0 | 62 | |
| GSE54994 | HERC5 | 51191 | 1 | 10 | 42 | |
| GSE60625 | HERC5 | 51191 | 0 | 0 | 11 | |
| GSE74703 | HERC5 | 51191 | 0 | 11 | 25 | |
| GSE74704 | HERC5 | 51191 | 1 | 7 | 12 | |
| TCGA | HERC5 | 51191 | 12 | 37 | 47 |
Total number of gains: 27; Total number of losses: 158; Total Number of normals: 303.
Somatic mutations of HERC5:
Generating mutation plots.
Highly correlated genes for HERC5:
Showing top 20/1376 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HERC5 | CD80 | 0.808689 | 3 | 0 | 3 |
| HERC5 | DDX60 | 0.803938 | 12 | 0 | 12 |
| HERC5 | IFI44 | 0.80378 | 12 | 0 | 12 |
| HERC5 | RNF213 | 0.784014 | 3 | 0 | 3 |
| HERC5 | IFI35 | 0.767269 | 13 | 0 | 12 |
| HERC5 | IFIT1 | 0.761428 | 13 | 0 | 12 |
| HERC5 | IFITM1 | 0.756183 | 10 | 0 | 10 |
| HERC5 | IFI6 | 0.75563 | 12 | 0 | 11 |
| HERC5 | USP41 | 0.751173 | 3 | 0 | 3 |
| HERC5 | FCGR3A | 0.75006 | 3 | 0 | 3 |
| HERC5 | CMPK2 | 0.747257 | 8 | 0 | 7 |
| HERC5 | IFIT3 | 0.746243 | 13 | 0 | 12 |
| HERC5 | IFI44L | 0.745501 | 13 | 0 | 11 |
| HERC5 | RSAD2 | 0.728613 | 12 | 0 | 11 |
| HERC5 | FCHO1 | 0.727148 | 3 | 0 | 3 |
| HERC5 | CAPN12 | 0.725586 | 3 | 0 | 3 |
| HERC5 | RTP4 | 0.723513 | 12 | 0 | 12 |
| HERC5 | ISG15 | 0.723381 | 12 | 0 | 11 |
| HERC5 | ADAR | 0.720843 | 11 | 0 | 9 |
| HERC5 | DDX60L | 0.717563 | 6 | 0 | 5 |
For details and further investigation, click here
