IFIT3

 

Full name: interferon induced protein with tetratricopeptide repeats 3 Alias Symbol: ISG60|RIG-G|CIG-49|IFI60|GARG-49|IRG2
Type: protein-coding gene Cytoband: 10q23.31
Entrez ID: 3437 HGNC ID: HGNC:5411 Ensembl Gene: ENSG00000119917 OMIM ID: 604650
Drug and gene relationship at DGIdb

 

Expression of IFIT3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IFIT3 3437 229450_at 0.4748 0.7618
GSE20347 IFIT3 3437 204747_at 1.0861 0.0004
GSE23400 IFIT3 3437 204747_at 0.6272 0.0000
GSE26886 IFIT3 3437 229450_at 2.1121 0.0140
GSE29001 IFIT3 3437 204747_at 0.7946 0.0008
GSE38129 IFIT3 3437 204747_at 0.7888 0.0005
GSE45670 IFIT3 3437 229450_at 1.9760 0.0019
GSE53622 IFIT3 3437 150042 1.2255 0.0000
GSE53624 IFIT3 3437 150042 1.6605 0.0000
GSE63941 IFIT3 3437 204747_at -0.9362 0.4811
GSE77861 IFIT3 3437 204747_at 0.0565 0.8734
GSE97050 IFIT3 3437 A_33_P3283611 0.5234 0.2575
SRP007169 IFIT3 3437 RNAseq 2.9434 0.0000
SRP008496 IFIT3 3437 RNAseq 2.7503 0.0000
SRP064894 IFIT3 3437 RNAseq 2.6186 0.0000
SRP133303 IFIT3 3437 RNAseq 1.6703 0.0000
SRP159526 IFIT3 3437 RNAseq 0.3048 0.7229
SRP193095 IFIT3 3437 RNAseq 1.8180 0.0000
SRP219564 IFIT3 3437 RNAseq 2.1465 0.0264
TCGA IFIT3 3437 RNAseq 0.6315 0.0000

Upregulated datasets: 11; Downregulated datasets: 0.  

 

Survival by IFIT3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IFIT3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IFIT3 3437 2 7 21
GSE20123 IFIT3 3437 2 6 22
GSE43470 IFIT3 3437 0 8 35
GSE46452 IFIT3 3437 0 11 48
GSE47630 IFIT3 3437 2 14 24
GSE54993 IFIT3 3437 7 0 63
GSE54994 IFIT3 3437 1 11 41
GSE60625 IFIT3 3437 0 0 11
GSE74703 IFIT3 3437 0 6 30
GSE74704 IFIT3 3437 1 4 15
TCGA IFIT3 3437 8 27 61

Total number of gains: 23; Total number of losses: 94; Total Number of normals: 371.  

 

Somatic mutations of IFIT3:

 

Generating mutation plots.

 

Highly correlated genes for IFIT3:

 

Showing top 20/303 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IFIT3IFIT10.83110913012
IFIT3IFI44L0.81259313013
IFIT3RSAD20.80983913013
IFIT3IFI440.80866513013
IFIT3DDX600.78541313013
IFIT3ISG150.78087813012
IFIT3IFI350.76235113012
IFIT3IFITM10.760887909
IFIT3EPSTI10.760756808
IFIT3HERC50.74624313012
IFIT3XAF10.74385713013
IFIT3IFI60.74367613012
IFIT3USP410.737939303
IFIT3UBE2L60.73325613011
IFIT3CMPK20.725877908
IFIT3OAS20.72157513012
IFIT3MX20.72124411010
IFIT3USP180.7095312012
IFIT3TRIM690.697286505
IFIT3RTP40.69356513013

For details and further investigation, click here