| Full name: lysosomal associated membrane protein 3 | Alias Symbol: LAMP|TSC403|DC-LAMP|DCLAMP|CD208 | ||
| Type: protein-coding gene | Cytoband: 3q27.1 | ||
| Entrez ID: 27074 | HGNC ID: HGNC:14582 | Ensembl Gene: ENSG00000078081 | OMIM ID: 605883 |
| Drug and gene relationship at DGIdb | |||
Expression of LAMP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAMP3 | 27074 | 205569_at | 1.2680 | 0.1726 | |
| GSE20347 | LAMP3 | 27074 | 205569_at | 1.7021 | 0.0000 | |
| GSE23400 | LAMP3 | 27074 | 205569_at | 1.4183 | 0.0000 | |
| GSE26886 | LAMP3 | 27074 | 205569_at | 1.4343 | 0.0069 | |
| GSE29001 | LAMP3 | 27074 | 205569_at | 2.0733 | 0.0002 | |
| GSE38129 | LAMP3 | 27074 | 205569_at | 2.2260 | 0.0000 | |
| GSE45670 | LAMP3 | 27074 | 205569_at | 2.6491 | 0.0000 | |
| GSE53622 | LAMP3 | 27074 | 121473 | 1.3413 | 0.0000 | |
| GSE53624 | LAMP3 | 27074 | 121473 | 1.4982 | 0.0000 | |
| GSE63941 | LAMP3 | 27074 | 205569_at | 4.4979 | 0.0029 | |
| GSE77861 | LAMP3 | 27074 | 205569_at | 1.0999 | 0.0905 | |
| GSE97050 | LAMP3 | 27074 | A_23_P29773 | 0.9764 | 0.1450 | |
| SRP007169 | LAMP3 | 27074 | RNAseq | 4.0427 | 0.0000 | |
| SRP008496 | LAMP3 | 27074 | RNAseq | 2.9560 | 0.0001 | |
| SRP064894 | LAMP3 | 27074 | RNAseq | 2.1881 | 0.0000 | |
| SRP133303 | LAMP3 | 27074 | RNAseq | 1.7377 | 0.0000 | |
| SRP159526 | LAMP3 | 27074 | RNAseq | 0.6993 | 0.1987 | |
| SRP193095 | LAMP3 | 27074 | RNAseq | 1.9517 | 0.0000 | |
| TCGA | LAMP3 | 27074 | RNAseq | 1.5898 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by LAMP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LAMP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAMP3 | 27074 | 25 | 0 | 5 | |
| GSE20123 | LAMP3 | 27074 | 25 | 0 | 5 | |
| GSE43470 | LAMP3 | 27074 | 24 | 0 | 19 | |
| GSE46452 | LAMP3 | 27074 | 19 | 1 | 39 | |
| GSE47630 | LAMP3 | 27074 | 27 | 2 | 11 | |
| GSE54993 | LAMP3 | 27074 | 1 | 19 | 50 | |
| GSE54994 | LAMP3 | 27074 | 41 | 0 | 12 | |
| GSE60625 | LAMP3 | 27074 | 0 | 6 | 5 | |
| GSE74703 | LAMP3 | 27074 | 20 | 0 | 16 | |
| GSE74704 | LAMP3 | 27074 | 17 | 0 | 3 | |
| TCGA | LAMP3 | 27074 | 77 | 0 | 19 |
Total number of gains: 276; Total number of losses: 28; Total Number of normals: 184.
Somatic mutations of LAMP3:
Generating mutation plots.
Highly correlated genes for LAMP3:
Showing top 20/1139 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAMP3 | PARP12 | 0.749819 | 12 | 0 | 11 |
| LAMP3 | RTP4 | 0.745156 | 11 | 0 | 11 |
| LAMP3 | ZAP70 | 0.73165 | 4 | 0 | 4 |
| LAMP3 | POU5F2 | 0.731523 | 3 | 0 | 3 |
| LAMP3 | USP41 | 0.730476 | 3 | 0 | 3 |
| LAMP3 | ISG15 | 0.727859 | 12 | 0 | 12 |
| LAMP3 | DDX60 | 0.726425 | 12 | 0 | 11 |
| LAMP3 | PARP9 | 0.723568 | 7 | 0 | 7 |
| LAMP3 | PARP14 | 0.714093 | 8 | 0 | 8 |
| LAMP3 | TIGIT | 0.711537 | 6 | 0 | 6 |
| LAMP3 | UBE2L6 | 0.710019 | 12 | 0 | 12 |
| LAMP3 | USP18 | 0.709432 | 12 | 0 | 11 |
| LAMP3 | OAS2 | 0.704888 | 12 | 0 | 12 |
| LAMP3 | IFI44 | 0.702069 | 12 | 0 | 11 |
| LAMP3 | NLRC5 | 0.701442 | 6 | 0 | 6 |
| LAMP3 | EIF2A | 0.700068 | 3 | 0 | 3 |
| LAMP3 | PREX1 | 0.699425 | 3 | 0 | 3 |
| LAMP3 | IFI35 | 0.699351 | 12 | 0 | 11 |
| LAMP3 | OAS3 | 0.69756 | 13 | 0 | 11 |
| LAMP3 | RSAD2 | 0.691868 | 11 | 0 | 10 |
For details and further investigation, click here
