| Full name: lin-7 homolog C, crumbs cell polarity complex component | Alias Symbol: MALS-3|Lin7c|LIN-7C|LIN-7-C|VELI3|FLJ11215 | ||
| Type: protein-coding gene | Cytoband: 11p14 | ||
| Entrez ID: 55327 | HGNC ID: HGNC:17789 | Ensembl Gene: ENSG00000148943 | OMIM ID: 612332 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LIN7C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIN7C | 55327 | 221568_s_at | -0.3179 | 0.1322 | |
| GSE20347 | LIN7C | 55327 | 221568_s_at | -0.7893 | 0.0022 | |
| GSE23400 | LIN7C | 55327 | 221568_s_at | -0.0056 | 0.9544 | |
| GSE26886 | LIN7C | 55327 | 221568_s_at | -1.0232 | 0.0000 | |
| GSE29001 | LIN7C | 55327 | 221568_s_at | -0.0783 | 0.6154 | |
| GSE38129 | LIN7C | 55327 | 221568_s_at | -0.4702 | 0.0042 | |
| GSE45670 | LIN7C | 55327 | 221568_s_at | -0.2548 | 0.0866 | |
| GSE63941 | LIN7C | 55327 | 221568_s_at | -0.3696 | 0.2907 | |
| GSE77861 | LIN7C | 55327 | 221568_s_at | -0.0212 | 0.9593 | |
| SRP007169 | LIN7C | 55327 | RNAseq | 0.1813 | 0.6352 | |
| SRP008496 | LIN7C | 55327 | RNAseq | 0.5948 | 0.0251 | |
| SRP064894 | LIN7C | 55327 | RNAseq | -0.3465 | 0.0469 | |
| SRP133303 | LIN7C | 55327 | RNAseq | 0.3383 | 0.1917 | |
| SRP159526 | LIN7C | 55327 | RNAseq | -0.2904 | 0.3410 | |
| SRP193095 | LIN7C | 55327 | RNAseq | -0.6123 | 0.0000 | |
| SRP219564 | LIN7C | 55327 | RNAseq | -0.1684 | 0.4732 | |
| TCGA | LIN7C | 55327 | RNAseq | -0.0737 | 0.1351 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by LIN7C expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of LIN7C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIN7C | 55327 | 1 | 9 | 20 | |
| GSE20123 | LIN7C | 55327 | 1 | 8 | 21 | |
| GSE43470 | LIN7C | 55327 | 1 | 5 | 37 | |
| GSE46452 | LIN7C | 55327 | 7 | 5 | 47 | |
| GSE47630 | LIN7C | 55327 | 3 | 10 | 27 | |
| GSE54993 | LIN7C | 55327 | 3 | 0 | 67 | |
| GSE54994 | LIN7C | 55327 | 4 | 11 | 38 | |
| GSE60625 | LIN7C | 55327 | 0 | 0 | 11 | |
| GSE74703 | LIN7C | 55327 | 1 | 3 | 32 | |
| GSE74704 | LIN7C | 55327 | 0 | 8 | 12 | |
| TCGA | LIN7C | 55327 | 12 | 24 | 60 |
Total number of gains: 33; Total number of losses: 83; Total Number of normals: 372.
Somatic mutations of LIN7C:
Generating mutation plots.
Highly correlated genes for LIN7C:
Showing top 20/359 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIN7C | SPATA18 | 0.769648 | 3 | 0 | 3 |
| LIN7C | FAR1 | 0.709254 | 6 | 0 | 6 |
| LIN7C | KIAA2026 | 0.708952 | 4 | 0 | 4 |
| LIN7C | SLC13A4 | 0.708552 | 3 | 0 | 3 |
| LIN7C | ALAD | 0.697718 | 5 | 0 | 5 |
| LIN7C | TRIP4 | 0.676701 | 3 | 0 | 3 |
| LIN7C | LNX1 | 0.673186 | 4 | 0 | 3 |
| LIN7C | FOXN1 | 0.672258 | 3 | 0 | 3 |
| LIN7C | KDM6A | 0.670909 | 5 | 0 | 5 |
| LIN7C | BLOC1S2 | 0.667224 | 4 | 0 | 3 |
| LIN7C | LRP10 | 0.666677 | 4 | 0 | 3 |
| LIN7C | SPINK7 | 0.66567 | 3 | 0 | 3 |
| LIN7C | PHYHD1 | 0.66284 | 3 | 0 | 3 |
| LIN7C | ACADSB | 0.662469 | 4 | 0 | 4 |
| LIN7C | STK39 | 0.662077 | 4 | 0 | 3 |
| LIN7C | NIPSNAP3A | 0.658438 | 4 | 0 | 3 |
| LIN7C | LTN1 | 0.65507 | 3 | 0 | 3 |
| LIN7C | CDK19 | 0.652402 | 4 | 0 | 3 |
| LIN7C | SCNN1B | 0.650627 | 4 | 0 | 3 |
| LIN7C | ALDH9A1 | 0.649169 | 6 | 0 | 5 |
For details and further investigation, click here
