ITPR2

 

Full name: inositol 1,4,5-trisphosphate receptor type 2 Alias Symbol: IP3R2|CFAP48
Type: protein-coding gene Cytoband: 12p11.23
Entrez ID: 3709 HGNC ID: HGNC:6181 Ensembl Gene: ENSG00000123104 OMIM ID: 600144
Drug and gene relationship at DGIdb

 

ITPR2 involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04114Oocyte meiosis
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04918Thyroid hormone synthesis
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05010Alzheimer's disease
hsa05205Proteoglycans in cancer

 

Expression of ITPR2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ITPR2 3709 202660_at -1.2045 0.1281
GSE20347 ITPR2 3709 202660_at -2.4051 0.0000
GSE23400 ITPR2 3709 211360_s_at -0.1235 0.0002
GSE26886 ITPR2 3709 202660_at -1.0802 0.0003
GSE29001 ITPR2 3709 202660_at -1.3481 0.0333
GSE38129 ITPR2 3709 202660_at -1.7885 0.0000
GSE45670 ITPR2 3709 202660_at -1.2980 0.0005
GSE53622 ITPR2 3709 2415 -1.2504 0.0000
GSE53624 ITPR2 3709 2415 -1.6237 0.0000
GSE63941 ITPR2 3709 202660_at -0.6383 0.4931
GSE77861 ITPR2 3709 211360_s_at -0.1833 0.2704
GSE97050 ITPR2 3709 A_33_P3232294 -0.0039 0.9964
SRP007169 ITPR2 3709 RNAseq -1.5810 0.0000
SRP008496 ITPR2 3709 RNAseq -1.0531 0.0000
SRP064894 ITPR2 3709 RNAseq -1.3499 0.0000
SRP133303 ITPR2 3709 RNAseq -1.4004 0.0000
SRP159526 ITPR2 3709 RNAseq -1.2838 0.0120
SRP193095 ITPR2 3709 RNAseq -1.4157 0.0000
SRP219564 ITPR2 3709 RNAseq -0.9775 0.0718
TCGA ITPR2 3709 RNAseq -0.2399 0.0123

Upregulated datasets: 0; Downregulated datasets: 13.  

 

Survival by ITPR2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ITPR2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ITPR2 3709 10 1 19
GSE20123 ITPR2 3709 10 1 19
GSE43470 ITPR2 3709 9 4 30
GSE46452 ITPR2 3709 10 1 48
GSE47630 ITPR2 3709 14 0 26
GSE54993 ITPR2 3709 0 9 61
GSE54994 ITPR2 3709 11 2 40
GSE60625 ITPR2 3709 0 1 10
GSE74703 ITPR2 3709 9 3 24
GSE74704 ITPR2 3709 6 1 13
TCGA ITPR2 3709 44 6 46

Total number of gains: 123; Total number of losses: 29; Total Number of normals: 336.  

 

Somatic mutations of ITPR2:

 

Generating mutation plots.

 

Highly correlated genes for ITPR2:

 

Showing top 20/1527 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ITPR2BLNK0.786251909
ITPR2CA130.785789303
ITPR2FCHO20.777143606
ITPR2A2ML10.771883505
ITPR2SPINK70.761379505
ITPR2TMPRSS11B0.757083505
ITPR2MLKL0.746558303
ITPR2RASSF50.745297606
ITPR2GTF3C60.745293303
ITPR2TCP11L20.745057404
ITPR2PDLIM50.735148909
ITPR2ITSN20.733423909
ITPR2DMXL10.732562908
ITPR2GRPEL20.731947606
ITPR2SLC44A30.729709606
ITPR2TAB30.729609606
ITPR2ZNF503-AS10.72353505
ITPR2CAPNS20.722912404
ITPR2RAB100.719458504
ITPR2CCNYL10.718578504

For details and further investigation, click here