| Full name: jagged canonical Notch ligand 1 | Alias Symbol: AHD|AWS|HJ1|CD339 | ||
| Type: protein-coding gene | Cytoband: 20p12.2 | ||
| Entrez ID: 182 | HGNC ID: HGNC:6188 | Ensembl Gene: ENSG00000101384 | OMIM ID: 601920 |
| Drug and gene relationship at DGIdb | |||
JAG1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of JAG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | JAG1 | 182 | 209099_x_at | 0.0934 | 0.9200 | |
| GSE20347 | JAG1 | 182 | 209099_x_at | -0.1155 | 0.5059 | |
| GSE23400 | JAG1 | 182 | 209099_x_at | 0.5431 | 0.0000 | |
| GSE26886 | JAG1 | 182 | 209099_x_at | 0.1466 | 0.5874 | |
| GSE29001 | JAG1 | 182 | 209099_x_at | -0.0239 | 0.9550 | |
| GSE38129 | JAG1 | 182 | 216268_s_at | 0.2371 | 0.3419 | |
| GSE45670 | JAG1 | 182 | 209099_x_at | 0.1038 | 0.6397 | |
| GSE53622 | JAG1 | 182 | 112958 | 0.5037 | 0.0001 | |
| GSE53624 | JAG1 | 182 | 78945 | 0.3879 | 0.0026 | |
| GSE63941 | JAG1 | 182 | 209099_x_at | 0.4207 | 0.7070 | |
| GSE77861 | JAG1 | 182 | 209099_x_at | -0.0950 | 0.6236 | |
| GSE97050 | JAG1 | 182 | A_23_P210763 | 1.0643 | 0.1572 | |
| SRP007169 | JAG1 | 182 | RNAseq | 1.3652 | 0.0040 | |
| SRP008496 | JAG1 | 182 | RNAseq | 0.9921 | 0.0005 | |
| SRP064894 | JAG1 | 182 | RNAseq | 0.7669 | 0.0177 | |
| SRP133303 | JAG1 | 182 | RNAseq | 0.3356 | 0.1475 | |
| SRP159526 | JAG1 | 182 | RNAseq | 0.0981 | 0.7812 | |
| SRP193095 | JAG1 | 182 | RNAseq | -0.0118 | 0.9508 | |
| SRP219564 | JAG1 | 182 | RNAseq | 0.0656 | 0.9166 | |
| TCGA | JAG1 | 182 | RNAseq | 0.3458 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by JAG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of JAG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | JAG1 | 182 | 10 | 1 | 19 | |
| GSE20123 | JAG1 | 182 | 10 | 1 | 19 | |
| GSE43470 | JAG1 | 182 | 11 | 1 | 31 | |
| GSE46452 | JAG1 | 182 | 26 | 1 | 32 | |
| GSE47630 | JAG1 | 182 | 18 | 4 | 18 | |
| GSE54993 | JAG1 | 182 | 1 | 14 | 55 | |
| GSE54994 | JAG1 | 182 | 25 | 1 | 27 | |
| GSE60625 | JAG1 | 182 | 0 | 0 | 11 | |
| GSE74703 | JAG1 | 182 | 8 | 1 | 27 | |
| GSE74704 | JAG1 | 182 | 5 | 1 | 14 | |
| TCGA | JAG1 | 182 | 43 | 10 | 43 |
Total number of gains: 157; Total number of losses: 35; Total Number of normals: 296.
Somatic mutations of JAG1:
Generating mutation plots.
Highly correlated genes for JAG1:
Showing top 20/367 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| JAG1 | SDHB | 0.759906 | 3 | 0 | 3 |
| JAG1 | STX3 | 0.754165 | 3 | 0 | 3 |
| JAG1 | VPS41 | 0.74739 | 3 | 0 | 3 |
| JAG1 | DTD1 | 0.745649 | 3 | 0 | 3 |
| JAG1 | C16orf72 | 0.744455 | 3 | 0 | 3 |
| JAG1 | MCTP1 | 0.734542 | 3 | 0 | 3 |
| JAG1 | EXOC4 | 0.729131 | 3 | 0 | 3 |
| JAG1 | ANKRD50 | 0.722425 | 3 | 0 | 3 |
| JAG1 | PCTP | 0.720226 | 3 | 0 | 3 |
| JAG1 | DIP2B | 0.711927 | 4 | 0 | 3 |
| JAG1 | SORD | 0.704158 | 4 | 0 | 3 |
| JAG1 | SLC37A3 | 0.699074 | 3 | 0 | 3 |
| JAG1 | CSTA | 0.698786 | 3 | 0 | 3 |
| JAG1 | CDCA4 | 0.693611 | 4 | 0 | 3 |
| JAG1 | SLC25A40 | 0.693199 | 3 | 0 | 3 |
| JAG1 | NANS | 0.691687 | 3 | 0 | 3 |
| JAG1 | MREG | 0.69077 | 4 | 0 | 3 |
| JAG1 | TRUB1 | 0.690523 | 3 | 0 | 3 |
| JAG1 | KIF3A | 0.688648 | 3 | 0 | 3 |
| JAG1 | ATP6V0D1 | 0.686099 | 3 | 0 | 3 |
For details and further investigation, click here
