| Full name: junctophilin 1 | Alias Symbol: JP-1 | ||
| Type: protein-coding gene | Cytoband: 8q21.11 | ||
| Entrez ID: 56704 | HGNC ID: HGNC:14201 | Ensembl Gene: ENSG00000104369 | OMIM ID: 605266 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of JPH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | JPH1 | 56704 | 229139_at | 2.1852 | 0.0249 | |
| GSE26886 | JPH1 | 56704 | 229139_at | 1.1908 | 0.0028 | |
| GSE45670 | JPH1 | 56704 | 229139_at | 0.9207 | 0.0525 | |
| GSE53622 | JPH1 | 56704 | 43626 | 0.5343 | 0.0124 | |
| GSE53624 | JPH1 | 56704 | 43626 | 1.1524 | 0.0000 | |
| GSE63941 | JPH1 | 56704 | 229139_at | 3.4397 | 0.0026 | |
| GSE77861 | JPH1 | 56704 | 229139_at | 1.1051 | 0.0818 | |
| SRP007169 | JPH1 | 56704 | RNAseq | 1.6015 | 0.0725 | |
| SRP064894 | JPH1 | 56704 | RNAseq | 1.4540 | 0.0023 | |
| SRP133303 | JPH1 | 56704 | RNAseq | 1.5265 | 0.0001 | |
| SRP159526 | JPH1 | 56704 | RNAseq | 1.7944 | 0.0006 | |
| SRP193095 | JPH1 | 56704 | RNAseq | 0.8323 | 0.0022 | |
| SRP219564 | JPH1 | 56704 | RNAseq | 1.6962 | 0.0278 | |
| TCGA | JPH1 | 56704 | RNAseq | 0.3824 | 0.0802 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by JPH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of JPH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | JPH1 | 56704 | 15 | 1 | 14 | |
| GSE20123 | JPH1 | 56704 | 16 | 1 | 13 | |
| GSE43470 | JPH1 | 56704 | 19 | 1 | 23 | |
| GSE46452 | JPH1 | 56704 | 22 | 0 | 37 | |
| GSE47630 | JPH1 | 56704 | 23 | 0 | 17 | |
| GSE54993 | JPH1 | 56704 | 0 | 19 | 51 | |
| GSE54994 | JPH1 | 56704 | 30 | 0 | 23 | |
| GSE60625 | JPH1 | 56704 | 0 | 4 | 7 | |
| GSE74703 | JPH1 | 56704 | 16 | 1 | 19 | |
| GSE74704 | JPH1 | 56704 | 11 | 0 | 9 | |
| TCGA | JPH1 | 56704 | 50 | 2 | 44 |
Total number of gains: 202; Total number of losses: 29; Total Number of normals: 257.
Somatic mutations of JPH1:
Generating mutation plots.
Highly correlated genes for JPH1:
Showing top 20/527 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| JPH1 | BRD9 | 0.725588 | 3 | 0 | 3 |
| JPH1 | PLEKHH1 | 0.701343 | 3 | 0 | 3 |
| JPH1 | GPR180 | 0.69827 | 3 | 0 | 3 |
| JPH1 | KCNG3 | 0.694967 | 3 | 0 | 3 |
| JPH1 | C4orf46 | 0.686457 | 3 | 0 | 3 |
| JPH1 | LRP8 | 0.682398 | 4 | 0 | 4 |
| JPH1 | MTERF3 | 0.679783 | 4 | 0 | 4 |
| JPH1 | USP28 | 0.679064 | 3 | 0 | 3 |
| JPH1 | CDCA2 | 0.673761 | 5 | 0 | 5 |
| JPH1 | TRIO | 0.672913 | 4 | 0 | 3 |
| JPH1 | RHPN2 | 0.671678 | 5 | 0 | 5 |
| JPH1 | FANCL | 0.669197 | 4 | 0 | 3 |
| JPH1 | CEP72 | 0.664281 | 5 | 0 | 3 |
| JPH1 | CMTM4 | 0.662813 | 4 | 0 | 3 |
| JPH1 | LPCAT1 | 0.661935 | 4 | 0 | 3 |
| JPH1 | HOXC9 | 0.658924 | 4 | 0 | 4 |
| JPH1 | LAMA5 | 0.653192 | 4 | 0 | 3 |
| JPH1 | DTD2 | 0.653014 | 3 | 0 | 3 |
| JPH1 | CA9 | 0.649515 | 3 | 0 | 3 |
| JPH1 | DNAH14 | 0.64849 | 6 | 0 | 4 |
For details and further investigation, click here
