| Full name: potassium two pore domain channel subfamily K member 10 | Alias Symbol: K2p10.1|TREK-2|TREK2|PPP1R97 | ||
| Type: protein-coding gene | Cytoband: 14q31.3 | ||
| Entrez ID: 54207 | HGNC ID: HGNC:6273 | Ensembl Gene: ENSG00000100433 | OMIM ID: 605873 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNK10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNK10 | 54207 | 220727_at | 0.1513 | 0.8711 | |
| GSE20347 | KCNK10 | 54207 | 220727_at | -0.2092 | 0.1552 | |
| GSE23400 | KCNK10 | 54207 | 220727_at | 0.0076 | 0.8894 | |
| GSE26886 | KCNK10 | 54207 | 220727_at | -0.4991 | 0.0989 | |
| GSE29001 | KCNK10 | 54207 | 220727_at | -0.0497 | 0.9182 | |
| GSE38129 | KCNK10 | 54207 | 220727_at | -0.2037 | 0.2832 | |
| GSE45670 | KCNK10 | 54207 | 220727_at | 0.4974 | 0.0765 | |
| GSE53622 | KCNK10 | 54207 | 49641 | -0.2246 | 0.5757 | |
| GSE53624 | KCNK10 | 54207 | 49641 | -0.6613 | 0.0143 | |
| GSE63941 | KCNK10 | 54207 | 220727_at | 0.3115 | 0.1338 | |
| GSE77861 | KCNK10 | 54207 | 220727_at | -0.1358 | 0.5565 | |
| SRP064894 | KCNK10 | 54207 | RNAseq | 0.7523 | 0.1684 | |
| SRP133303 | KCNK10 | 54207 | RNAseq | 1.4178 | 0.0015 | |
| SRP159526 | KCNK10 | 54207 | RNAseq | -1.3847 | 0.0357 | |
| SRP193095 | KCNK10 | 54207 | RNAseq | -0.0837 | 0.7849 | |
| TCGA | KCNK10 | 54207 | RNAseq | 0.0123 | 0.9789 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by KCNK10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNK10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNK10 | 54207 | 7 | 4 | 19 | |
| GSE20123 | KCNK10 | 54207 | 7 | 4 | 19 | |
| GSE43470 | KCNK10 | 54207 | 7 | 3 | 33 | |
| GSE46452 | KCNK10 | 54207 | 16 | 3 | 40 | |
| GSE47630 | KCNK10 | 54207 | 11 | 8 | 21 | |
| GSE54993 | KCNK10 | 54207 | 3 | 8 | 59 | |
| GSE54994 | KCNK10 | 54207 | 19 | 4 | 30 | |
| GSE60625 | KCNK10 | 54207 | 0 | 2 | 9 | |
| GSE74703 | KCNK10 | 54207 | 6 | 3 | 27 | |
| GSE74704 | KCNK10 | 54207 | 4 | 4 | 12 | |
| TCGA | KCNK10 | 54207 | 31 | 21 | 44 |
Total number of gains: 111; Total number of losses: 64; Total Number of normals: 313.
Somatic mutations of KCNK10:
Generating mutation plots.
Highly correlated genes for KCNK10:
Showing top 20/32 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNK10 | PRR35 | 0.651365 | 3 | 0 | 3 |
| KCNK10 | ARHGEF37 | 0.601653 | 4 | 0 | 4 |
| KCNK10 | PEX10 | 0.590386 | 3 | 0 | 3 |
| KCNK10 | POU3F1 | 0.58423 | 6 | 0 | 4 |
| KCNK10 | KCNQ1 | 0.578069 | 3 | 0 | 3 |
| KCNK10 | PLCB3 | 0.573645 | 3 | 0 | 3 |
| KCNK10 | GJB3 | 0.572268 | 7 | 0 | 4 |
| KCNK10 | CROT | 0.572098 | 3 | 0 | 3 |
| KCNK10 | PPP1R26-AS1 | 0.571707 | 3 | 0 | 3 |
| KCNK10 | TUBA4A | 0.563774 | 4 | 0 | 3 |
| KCNK10 | CYP3A5 | 0.562598 | 3 | 0 | 3 |
| KCNK10 | NEUROG1 | 0.555467 | 4 | 0 | 3 |
| KCNK10 | PGLYRP4 | 0.548206 | 7 | 0 | 5 |
| KCNK10 | CEP170B | 0.545302 | 4 | 0 | 3 |
| KCNK10 | PLA2G4F | 0.541595 | 3 | 0 | 3 |
| KCNK10 | ALOXE3 | 0.538789 | 5 | 0 | 3 |
| KCNK10 | SREBF2 | 0.534765 | 3 | 0 | 3 |
| KCNK10 | PYGL | 0.533769 | 4 | 0 | 3 |
| KCNK10 | PRRG4 | 0.531189 | 6 | 0 | 4 |
| KCNK10 | CNOT1 | 0.530559 | 3 | 0 | 3 |
For details and further investigation, click here
