PLCB3

 

Full name: phospholipase C beta 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 11q13.1
Entrez ID: 5331 HGNC ID: HGNC:9056 Ensembl Gene: ENSG00000149782 OMIM ID: 600230
Drug and gene relationship at DGIdb

 

PLCB3 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04062Chemokine signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05010Alzheimer's disease
hsa05016Huntington's disease
hsa05142Chagas disease (American trypanosomiasis)

 

Expression of PLCB3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLCB3 5331 213384_x_at 0.2651 0.5526
GSE20347 PLCB3 5331 213384_x_at -0.1011 0.4330
GSE23400 PLCB3 5331 213384_x_at 0.0673 0.2889
GSE26886 PLCB3 5331 213384_x_at 0.0083 0.9685
GSE29001 PLCB3 5331 213384_x_at -0.2314 0.2914
GSE38129 PLCB3 5331 213384_x_at -0.0459 0.6887
GSE45670 PLCB3 5331 213384_x_at 0.2043 0.0469
GSE53622 PLCB3 5331 59917 -0.2814 0.0046
GSE53624 PLCB3 5331 59917 -0.1423 0.0835
GSE63941 PLCB3 5331 213384_x_at 0.2208 0.4064
GSE77861 PLCB3 5331 213384_x_at -0.1304 0.4301
GSE97050 PLCB3 5331 A_33_P3260623 0.4667 0.1978
SRP007169 PLCB3 5331 RNAseq -0.1954 0.6723
SRP008496 PLCB3 5331 RNAseq -0.3588 0.1852
SRP064894 PLCB3 5331 RNAseq -0.0566 0.7525
SRP133303 PLCB3 5331 RNAseq -0.1821 0.4342
SRP159526 PLCB3 5331 RNAseq -0.3658 0.0354
SRP193095 PLCB3 5331 RNAseq -0.3435 0.0766
SRP219564 PLCB3 5331 RNAseq -0.2323 0.5392
TCGA PLCB3 5331 RNAseq 0.1737 0.0055

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PLCB3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLCB3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLCB3 5331 6 5 19
GSE20123 PLCB3 5331 6 5 19
GSE43470 PLCB3 5331 1 3 39
GSE46452 PLCB3 5331 8 4 47
GSE47630 PLCB3 5331 4 6 30
GSE54993 PLCB3 5331 3 0 67
GSE54994 PLCB3 5331 5 5 43
GSE60625 PLCB3 5331 0 4 7
GSE74703 PLCB3 5331 1 1 34
GSE74704 PLCB3 5331 4 3 13
TCGA PLCB3 5331 20 9 67

Total number of gains: 58; Total number of losses: 45; Total Number of normals: 385.  

 

Somatic mutations of PLCB3:

 

Generating mutation plots.

 

Highly correlated genes for PLCB3:

 

Showing top 20/368 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLCB3RHOF0.727202303
PLCB3AMMECR10.703373303
PLCB3GTPBP20.695557404
PLCB3GPR870.690769404
PLCB3MTFP10.679197303
PLCB3SNX80.652749303
PLCB3DEPDC1B0.650713303
PLCB3SLC25A390.6484303
PLCB3ZNRF40.630288303
PLCB3FAM160B20.628867303
PLCB3CDS10.628492504
PLCB3MICALL20.625667303
PLCB3ESRRA0.6245811008
PLCB3VDR0.617127706
PLCB3RPS6KA40.616016908
PLCB3IFI27L10.614173403
PLCB3RIN10.61318711010
PLCB3SIPA10.613003403
PLCB3HPCA0.612411403
PLCB3SH3TC10.612409303

For details and further investigation, click here