| Full name: protein regulator of cytokinesis 1 | Alias Symbol: ASE1 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 9055 | HGNC ID: HGNC:9341 | Ensembl Gene: ENSG00000198901 | OMIM ID: 603484 |
| Drug and gene relationship at DGIdb | |||
Expression of PRC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRC1 | 9055 | 218009_s_at | 1.1288 | 0.1166 | |
| GSE20347 | PRC1 | 9055 | 218009_s_at | 1.5410 | 0.0000 | |
| GSE23400 | PRC1 | 9055 | 218009_s_at | 1.7636 | 0.0000 | |
| GSE26886 | PRC1 | 9055 | 218009_s_at | 0.5075 | 0.0735 | |
| GSE29001 | PRC1 | 9055 | 218009_s_at | 1.8059 | 0.0000 | |
| GSE38129 | PRC1 | 9055 | 218009_s_at | 2.0838 | 0.0000 | |
| GSE45670 | PRC1 | 9055 | 218009_s_at | 1.2720 | 0.0002 | |
| GSE53622 | PRC1 | 9055 | 123191 | 1.4968 | 0.0000 | |
| GSE53624 | PRC1 | 9055 | 123191 | 1.5359 | 0.0000 | |
| GSE63941 | PRC1 | 9055 | 218009_s_at | 2.7059 | 0.0008 | |
| GSE77861 | PRC1 | 9055 | 218009_s_at | 1.0474 | 0.0425 | |
| GSE97050 | PRC1 | 9055 | A_23_P206059 | 1.1844 | 0.1143 | |
| SRP007169 | PRC1 | 9055 | RNAseq | 2.3164 | 0.0000 | |
| SRP008496 | PRC1 | 9055 | RNAseq | 1.9962 | 0.0000 | |
| SRP064894 | PRC1 | 9055 | RNAseq | 1.0836 | 0.0004 | |
| SRP133303 | PRC1 | 9055 | RNAseq | 1.2965 | 0.0006 | |
| SRP159526 | PRC1 | 9055 | RNAseq | 1.3317 | 0.0000 | |
| SRP193095 | PRC1 | 9055 | RNAseq | 1.0192 | 0.0000 | |
| SRP219564 | PRC1 | 9055 | RNAseq | 0.8731 | 0.1421 | |
| TCGA | PRC1 | 9055 | RNAseq | 0.8102 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by PRC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRC1 | 9055 | 7 | 3 | 20 | |
| GSE20123 | PRC1 | 9055 | 7 | 3 | 20 | |
| GSE43470 | PRC1 | 9055 | 5 | 5 | 33 | |
| GSE46452 | PRC1 | 9055 | 3 | 7 | 49 | |
| GSE47630 | PRC1 | 9055 | 8 | 11 | 21 | |
| GSE54993 | PRC1 | 9055 | 4 | 6 | 60 | |
| GSE54994 | PRC1 | 9055 | 7 | 7 | 39 | |
| GSE60625 | PRC1 | 9055 | 4 | 0 | 7 | |
| GSE74703 | PRC1 | 9055 | 4 | 4 | 28 | |
| GSE74704 | PRC1 | 9055 | 3 | 3 | 14 | |
| TCGA | PRC1 | 9055 | 18 | 12 | 66 |
Total number of gains: 70; Total number of losses: 61; Total Number of normals: 357.
Somatic mutations of PRC1:
Generating mutation plots.
Highly correlated genes for PRC1:
Showing top 20/1895 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRC1 | NUSAP1 | 0.863632 | 13 | 0 | 13 |
| PRC1 | BUB1B | 0.86326 | 10 | 0 | 10 |
| PRC1 | CEP55 | 0.852982 | 13 | 0 | 13 |
| PRC1 | FANCI | 0.852139 | 13 | 0 | 13 |
| PRC1 | NEK2 | 0.844425 | 13 | 0 | 13 |
| PRC1 | KIF23 | 0.840845 | 13 | 0 | 13 |
| PRC1 | CCNB2 | 0.839109 | 13 | 0 | 12 |
| PRC1 | KNSTRN | 0.836238 | 7 | 0 | 7 |
| PRC1 | CDK1 | 0.833534 | 12 | 0 | 12 |
| PRC1 | KIF14 | 0.832379 | 13 | 0 | 13 |
| PRC1 | BLM | 0.828613 | 13 | 0 | 13 |
| PRC1 | NCAPH | 0.827726 | 9 | 0 | 9 |
| PRC1 | TPX2 | 0.825339 | 13 | 0 | 13 |
| PRC1 | UBE2C | 0.824491 | 13 | 0 | 13 |
| PRC1 | ASPM | 0.822534 | 13 | 0 | 13 |
| PRC1 | CENPF | 0.820208 | 13 | 0 | 12 |
| PRC1 | TOP2A | 0.817842 | 13 | 0 | 12 |
| PRC1 | GINS1 | 0.813345 | 12 | 0 | 12 |
| PRC1 | MMS22L | 0.813085 | 3 | 0 | 3 |
| PRC1 | DTL | 0.812456 | 13 | 0 | 12 |
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