| Full name: serine and arginine rich splicing factor 5 | Alias Symbol: SRP40|HRS | ||
| Type: protein-coding gene | Cytoband: 14q24 | ||
| Entrez ID: 6430 | HGNC ID: HGNC:10787 | Ensembl Gene: ENSG00000100650 | OMIM ID: 600914 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SRSF5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05168 | Herpes simplex infection |
Expression of SRSF5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRSF5 | 6430 | 212266_s_at | -0.8066 | 0.0368 | |
| GSE20347 | SRSF5 | 6430 | 212266_s_at | -0.6479 | 0.0001 | |
| GSE23400 | SRSF5 | 6430 | 212266_s_at | -0.5436 | 0.0000 | |
| GSE26886 | SRSF5 | 6430 | 203380_x_at | -0.6817 | 0.0191 | |
| GSE29001 | SRSF5 | 6430 | 203380_x_at | -0.3160 | 0.1996 | |
| GSE38129 | SRSF5 | 6430 | 212266_s_at | -0.6012 | 0.0000 | |
| GSE45670 | SRSF5 | 6430 | 212266_s_at | -0.5301 | 0.0000 | |
| GSE53622 | SRSF5 | 6430 | 57517 | -0.4701 | 0.0000 | |
| GSE53624 | SRSF5 | 6430 | 57517 | -0.6237 | 0.0000 | |
| GSE63941 | SRSF5 | 6430 | 212266_s_at | 1.1202 | 0.0052 | |
| GSE77861 | SRSF5 | 6430 | 212266_s_at | -0.1867 | 0.6164 | |
| GSE97050 | SRSF5 | 6430 | A_33_P3366146 | -0.3670 | 0.2089 | |
| SRP007169 | SRSF5 | 6430 | RNAseq | -2.0873 | 0.0000 | |
| SRP008496 | SRSF5 | 6430 | RNAseq | -1.6827 | 0.0000 | |
| SRP064894 | SRSF5 | 6430 | RNAseq | -1.0439 | 0.0000 | |
| SRP133303 | SRSF5 | 6430 | RNAseq | -0.9019 | 0.0000 | |
| SRP159526 | SRSF5 | 6430 | RNAseq | -1.1403 | 0.0000 | |
| SRP193095 | SRSF5 | 6430 | RNAseq | -0.8837 | 0.0000 | |
| SRP219564 | SRSF5 | 6430 | RNAseq | -0.5586 | 0.0773 |
Upregulated datasets: 1; Downregulated datasets: 4.
Survival by SRSF5 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SRSF5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRSF5 | 6430 | 8 | 3 | 19 | |
| GSE20123 | SRSF5 | 6430 | 8 | 3 | 19 | |
| GSE43470 | SRSF5 | 6430 | 8 | 3 | 32 | |
| GSE46452 | SRSF5 | 6430 | 16 | 3 | 40 | |
| GSE47630 | SRSF5 | 6430 | 11 | 9 | 20 | |
| GSE54993 | SRSF5 | 6430 | 3 | 9 | 58 | |
| GSE54994 | SRSF5 | 6430 | 18 | 5 | 30 | |
| GSE60625 | SRSF5 | 6430 | 0 | 2 | 9 | |
| GSE74703 | SRSF5 | 6430 | 7 | 3 | 26 | |
| GSE74704 | SRSF5 | 6430 | 3 | 3 | 14 | |
| TCGA | SRSF5 | 6430 | 32 | 16 | 48 |
Total number of gains: 114; Total number of losses: 59; Total Number of normals: 315.
Somatic mutations of SRSF5:
Generating mutation plots.
Highly correlated genes for SRSF5:
Showing top 20/801 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRSF5 | CCDC7 | 0.761469 | 3 | 0 | 3 |
| SRSF5 | WSB1 | 0.737809 | 4 | 0 | 4 |
| SRSF5 | ATF7 | 0.722195 | 3 | 0 | 3 |
| SRSF5 | RBM20 | 0.720014 | 4 | 0 | 4 |
| SRSF5 | GSK3A | 0.714325 | 3 | 0 | 3 |
| SRSF5 | NUCB1 | 0.714235 | 3 | 0 | 3 |
| SRSF5 | SPRYD4 | 0.71423 | 3 | 0 | 3 |
| SRSF5 | TMEM132C | 0.706879 | 3 | 0 | 3 |
| SRSF5 | EPN1 | 0.701464 | 3 | 0 | 3 |
| SRSF5 | SRP68 | 0.701333 | 3 | 0 | 3 |
| SRSF5 | FLT1 | 0.700623 | 3 | 0 | 3 |
| SRSF5 | FKBP2 | 0.700405 | 3 | 0 | 3 |
| SRSF5 | GPCPD1 | 0.690519 | 3 | 0 | 3 |
| SRSF5 | UTRN | 0.689008 | 5 | 0 | 5 |
| SRSF5 | CLEC3B | 0.686389 | 3 | 0 | 3 |
| SRSF5 | PDCD4 | 0.685752 | 4 | 0 | 3 |
| SRSF5 | MTMR3 | 0.683229 | 8 | 0 | 8 |
| SRSF5 | NBPF11 | 0.683042 | 3 | 0 | 3 |
| SRSF5 | RSPH3 | 0.682316 | 5 | 0 | 5 |
| SRSF5 | TBRG1 | 0.681973 | 3 | 0 | 3 |
For details and further investigation, click here
