| Full name: kallikrein related peptidase 11 | Alias Symbol: TLSP | ||
| Type: protein-coding gene | Cytoband: 19q13.41 | ||
| Entrez ID: 11012 | HGNC ID: HGNC:6359 | Ensembl Gene: ENSG00000167757 | OMIM ID: 604434 |
| Drug and gene relationship at DGIdb | |||
Expression of KLK11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLK11 | 11012 | 205470_s_at | -2.6178 | 0.1328 | |
| GSE20347 | KLK11 | 11012 | 205470_s_at | -2.5624 | 0.0000 | |
| GSE23400 | KLK11 | 11012 | 205470_s_at | -1.9231 | 0.0000 | |
| GSE26886 | KLK11 | 11012 | 205470_s_at | -3.0843 | 0.0000 | |
| GSE29001 | KLK11 | 11012 | 205470_s_at | -2.4430 | 0.0001 | |
| GSE38129 | KLK11 | 11012 | 205470_s_at | -1.8115 | 0.0005 | |
| GSE45670 | KLK11 | 11012 | 205470_s_at | -0.5903 | 0.0500 | |
| GSE53622 | KLK11 | 11012 | 11977 | -2.1938 | 0.0000 | |
| GSE53624 | KLK11 | 11012 | 11977 | -2.7355 | 0.0000 | |
| GSE63941 | KLK11 | 11012 | 205470_s_at | 1.5604 | 0.2524 | |
| GSE77861 | KLK11 | 11012 | 205470_s_at | -1.4223 | 0.0451 | |
| GSE97050 | KLK11 | 11012 | A_23_P101505 | -0.2478 | 0.6055 | |
| SRP007169 | KLK11 | 11012 | RNAseq | -3.8769 | 0.0192 | |
| SRP008496 | KLK11 | 11012 | RNAseq | -3.6067 | 0.0003 | |
| SRP064894 | KLK11 | 11012 | RNAseq | -3.5920 | 0.0000 | |
| SRP133303 | KLK11 | 11012 | RNAseq | -2.5793 | 0.0000 | |
| SRP159526 | KLK11 | 11012 | RNAseq | -3.2173 | 0.0003 | |
| SRP193095 | KLK11 | 11012 | RNAseq | -2.6921 | 0.0000 | |
| SRP219564 | KLK11 | 11012 | RNAseq | -3.4693 | 0.0018 | |
| TCGA | KLK11 | 11012 | RNAseq | -0.3228 | 0.2979 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by KLK11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLK11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLK11 | 11012 | 3 | 4 | 23 | |
| GSE20123 | KLK11 | 11012 | 3 | 3 | 24 | |
| GSE43470 | KLK11 | 11012 | 4 | 11 | 28 | |
| GSE46452 | KLK11 | 11012 | 45 | 1 | 13 | |
| GSE47630 | KLK11 | 11012 | 9 | 6 | 25 | |
| GSE54993 | KLK11 | 11012 | 17 | 4 | 49 | |
| GSE54994 | KLK11 | 11012 | 4 | 14 | 35 | |
| GSE60625 | KLK11 | 11012 | 9 | 0 | 2 | |
| GSE74703 | KLK11 | 11012 | 4 | 7 | 25 | |
| GSE74704 | KLK11 | 11012 | 3 | 1 | 16 | |
| TCGA | KLK11 | 11012 | 15 | 19 | 62 |
Total number of gains: 116; Total number of losses: 70; Total Number of normals: 302.
Somatic mutations of KLK11:
Generating mutation plots.
Highly correlated genes for KLK11:
Showing top 20/1387 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLK11 | KLK13 | 0.873104 | 13 | 0 | 13 |
| KLK11 | CYSRT1 | 0.868646 | 6 | 0 | 6 |
| KLK11 | VSIG10L | 0.844146 | 7 | 0 | 7 |
| KLK11 | SULT2B1 | 0.837777 | 10 | 0 | 10 |
| KLK11 | TGM3 | 0.821327 | 12 | 0 | 12 |
| KLK11 | CNFN | 0.820622 | 8 | 0 | 8 |
| KLK11 | SCEL | 0.815164 | 12 | 0 | 12 |
| KLK11 | MUC15 | 0.813334 | 7 | 0 | 7 |
| KLK11 | CLIC3 | 0.812607 | 10 | 0 | 9 |
| KLK11 | TGM1 | 0.807452 | 13 | 0 | 12 |
| KLK11 | TMEM40 | 0.804706 | 12 | 0 | 11 |
| KLK11 | TMPRSS11E | 0.804673 | 12 | 0 | 11 |
| KLK11 | EVPL | 0.802813 | 12 | 0 | 12 |
| KLK11 | GDPD3 | 0.801072 | 12 | 0 | 11 |
| KLK11 | UPK3B | 0.799746 | 3 | 0 | 3 |
| KLK11 | SPINK5 | 0.799566 | 12 | 0 | 11 |
| KLK11 | PGLYRP3 | 0.798277 | 4 | 0 | 4 |
| KLK11 | PPL | 0.793292 | 13 | 0 | 12 |
| KLK11 | A2ML1 | 0.792713 | 8 | 0 | 8 |
| KLK11 | SPRR2D | 0.790572 | 4 | 0 | 4 |
For details and further investigation, click here
