| Full name: kallikrein related peptidase 12 | Alias Symbol: KLK-L5 | ||
| Type: protein-coding gene | Cytoband: 19q13.41 | ||
| Entrez ID: 43849 | HGNC ID: HGNC:6360 | Ensembl Gene: ENSG00000186474 | OMIM ID: 605539 |
| Drug and gene relationship at DGIdb | |||
Expression of KLK12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLK12 | 43849 | 234316_x_at | -1.7294 | 0.2769 | |
| GSE20347 | KLK12 | 43849 | 220782_x_at | -2.7993 | 0.0000 | |
| GSE23400 | KLK12 | 43849 | 220782_x_at | -2.1940 | 0.0000 | |
| GSE26886 | KLK12 | 43849 | 234316_x_at | -4.0439 | 0.0000 | |
| GSE29001 | KLK12 | 43849 | 220782_x_at | -2.7517 | 0.0001 | |
| GSE38129 | KLK12 | 43849 | 220782_x_at | -2.1784 | 0.0001 | |
| GSE45670 | KLK12 | 43849 | 220782_x_at | -0.5901 | 0.2622 | |
| GSE53622 | KLK12 | 43849 | 40150 | -2.1857 | 0.0000 | |
| GSE53624 | KLK12 | 43849 | 40150 | -3.1296 | 0.0000 | |
| GSE63941 | KLK12 | 43849 | 234316_x_at | 0.4303 | 0.1108 | |
| GSE77861 | KLK12 | 43849 | 233586_s_at | -2.0281 | 0.0094 | |
| GSE97050 | KLK12 | 43849 | A_23_P500010 | -0.9215 | 0.0863 | |
| SRP007169 | KLK12 | 43849 | RNAseq | -5.7727 | 0.0080 | |
| SRP008496 | KLK12 | 43849 | RNAseq | -5.4908 | 0.0000 | |
| SRP064894 | KLK12 | 43849 | RNAseq | -4.5099 | 0.0000 | |
| SRP133303 | KLK12 | 43849 | RNAseq | -3.8093 | 0.0000 | |
| SRP159526 | KLK12 | 43849 | RNAseq | -4.7072 | 0.0023 | |
| SRP219564 | KLK12 | 43849 | RNAseq | -4.2213 | 0.0060 | |
| TCGA | KLK12 | 43849 | RNAseq | -0.0015 | 0.9979 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by KLK12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLK12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLK12 | 43849 | 3 | 4 | 23 | |
| GSE20123 | KLK12 | 43849 | 3 | 3 | 24 | |
| GSE43470 | KLK12 | 43849 | 4 | 11 | 28 | |
| GSE46452 | KLK12 | 43849 | 45 | 1 | 13 | |
| GSE47630 | KLK12 | 43849 | 9 | 6 | 25 | |
| GSE54993 | KLK12 | 43849 | 17 | 4 | 49 | |
| GSE54994 | KLK12 | 43849 | 4 | 14 | 35 | |
| GSE60625 | KLK12 | 43849 | 9 | 0 | 2 | |
| GSE74703 | KLK12 | 43849 | 4 | 7 | 25 | |
| GSE74704 | KLK12 | 43849 | 3 | 1 | 16 | |
| TCGA | KLK12 | 43849 | 15 | 19 | 62 |
Total number of gains: 116; Total number of losses: 70; Total Number of normals: 302.
Somatic mutations of KLK12:
Generating mutation plots.
Highly correlated genes for KLK12:
Showing top 20/1307 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLK12 | TGM1 | 0.804166 | 12 | 0 | 11 |
| KLK12 | TGM3 | 0.798565 | 13 | 0 | 12 |
| KLK12 | KLK13 | 0.7907 | 13 | 0 | 12 |
| KLK12 | CLIC3 | 0.780688 | 10 | 0 | 9 |
| KLK12 | FMO2 | 0.775103 | 10 | 0 | 10 |
| KLK12 | SPRR2B | 0.772828 | 4 | 0 | 4 |
| KLK12 | KLK11 | 0.768246 | 13 | 0 | 12 |
| KLK12 | PRSS3 | 0.763026 | 12 | 0 | 10 |
| KLK12 | ENDOU | 0.760736 | 12 | 0 | 10 |
| KLK12 | DUSP5 | 0.756477 | 10 | 0 | 9 |
| KLK12 | NCCRP1 | 0.755394 | 4 | 0 | 4 |
| KLK12 | GDPD3 | 0.754598 | 13 | 0 | 12 |
| KLK12 | PPL | 0.75307 | 13 | 0 | 12 |
| KLK12 | TMPRSS11E | 0.7525 | 12 | 0 | 10 |
| KLK12 | IL36A | 0.752139 | 11 | 0 | 10 |
| KLK12 | RHCG | 0.751047 | 13 | 0 | 12 |
| KLK12 | CEACAM7 | 0.749504 | 11 | 0 | 9 |
| KLK12 | CRISP3 | 0.749427 | 11 | 0 | 10 |
| KLK12 | EPGN | 0.747807 | 3 | 0 | 3 |
| KLK12 | TRIP10 | 0.747614 | 11 | 0 | 9 |
For details and further investigation, click here
