| Full name: kallikrein related peptidase 6 | Alias Symbol: Bssp|Klk7|neurosin | ||
| Type: protein-coding gene | Cytoband: 19q13.3 | ||
| Entrez ID: 5653 | HGNC ID: HGNC:6367 | Ensembl Gene: ENSG00000167755 | OMIM ID: 602652 |
| Drug and gene relationship at DGIdb | |||
Expression of KLK6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLK6 | 5653 | 204733_at | -1.7251 | 0.4692 | |
| GSE20347 | KLK6 | 5653 | 204733_at | -1.3293 | 0.0121 | |
| GSE23400 | KLK6 | 5653 | 204733_at | -0.9436 | 0.0003 | |
| GSE26886 | KLK6 | 5653 | 204733_at | -3.2789 | 0.0000 | |
| GSE29001 | KLK6 | 5653 | 204733_at | -0.9423 | 0.1030 | |
| GSE38129 | KLK6 | 5653 | 204733_at | -0.6417 | 0.2246 | |
| GSE45670 | KLK6 | 5653 | 204733_at | 2.4449 | 0.0000 | |
| GSE53622 | KLK6 | 5653 | 10878 | -0.2419 | 0.3260 | |
| GSE53624 | KLK6 | 5653 | 10878 | -0.8366 | 0.0000 | |
| GSE63941 | KLK6 | 5653 | 204733_at | 2.7046 | 0.0637 | |
| GSE77861 | KLK6 | 5653 | 204733_at | -0.3698 | 0.7419 | |
| GSE97050 | KLK6 | 5653 | A_24_P236935 | 2.4169 | 0.1189 | |
| SRP007169 | KLK6 | 5653 | RNAseq | -3.0597 | 0.1199 | |
| SRP008496 | KLK6 | 5653 | RNAseq | -2.7792 | 0.0077 | |
| SRP064894 | KLK6 | 5653 | RNAseq | -1.1466 | 0.1064 | |
| SRP133303 | KLK6 | 5653 | RNAseq | -0.5398 | 0.2308 | |
| SRP159526 | KLK6 | 5653 | RNAseq | -2.2421 | 0.0019 | |
| SRP219564 | KLK6 | 5653 | RNAseq | -3.4254 | 0.0188 | |
| TCGA | KLK6 | 5653 | RNAseq | 1.2119 | 0.0013 |
Upregulated datasets: 2; Downregulated datasets: 5.
Survival by KLK6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLK6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLK6 | 5653 | 3 | 4 | 23 | |
| GSE20123 | KLK6 | 5653 | 3 | 3 | 24 | |
| GSE43470 | KLK6 | 5653 | 4 | 11 | 28 | |
| GSE46452 | KLK6 | 5653 | 45 | 1 | 13 | |
| GSE47630 | KLK6 | 5653 | 9 | 6 | 25 | |
| GSE54993 | KLK6 | 5653 | 17 | 4 | 49 | |
| GSE54994 | KLK6 | 5653 | 4 | 14 | 35 | |
| GSE60625 | KLK6 | 5653 | 9 | 0 | 2 | |
| GSE74703 | KLK6 | 5653 | 4 | 7 | 25 | |
| GSE74704 | KLK6 | 5653 | 3 | 1 | 16 | |
| TCGA | KLK6 | 5653 | 15 | 19 | 62 |
Total number of gains: 116; Total number of losses: 70; Total Number of normals: 302.
Somatic mutations of KLK6:
Generating mutation plots.
Highly correlated genes for KLK6:
Showing top 20/301 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLK6 | KLK7 | 0.767804 | 13 | 0 | 11 |
| KLK6 | QPCT | 0.714726 | 3 | 0 | 3 |
| KLK6 | LYNX1 | 0.691798 | 5 | 0 | 5 |
| KLK6 | KLK10 | 0.682333 | 8 | 0 | 8 |
| KLK6 | SIAE | 0.679411 | 3 | 0 | 3 |
| KLK6 | SH3PXD2A-AS1 | 0.677142 | 3 | 0 | 3 |
| KLK6 | SMPD3 | 0.671141 | 4 | 0 | 3 |
| KLK6 | KLK8 | 0.66541 | 13 | 0 | 11 |
| KLK6 | SPRR2E | 0.662705 | 4 | 0 | 4 |
| KLK6 | KLK5 | 0.659524 | 13 | 0 | 12 |
| KLK6 | DMKN | 0.657995 | 7 | 0 | 5 |
| KLK6 | IL36B | 0.657022 | 4 | 0 | 4 |
| KLK6 | SULT2B1 | 0.656548 | 9 | 0 | 8 |
| KLK6 | PRSS2 | 0.656156 | 8 | 0 | 7 |
| KLK6 | SPRR2D | 0.655283 | 4 | 0 | 4 |
| KLK6 | ANKRD22 | 0.654168 | 4 | 0 | 4 |
| KLK6 | SLC35A4 | 0.652158 | 3 | 0 | 3 |
| KLK6 | SBSN | 0.651763 | 7 | 0 | 6 |
| KLK6 | SLC5A1 | 0.650781 | 12 | 0 | 11 |
| KLK6 | CHMP5 | 0.649605 | 3 | 0 | 3 |
For details and further investigation, click here
