| Full name: kallikrein related peptidase 7 | Alias Symbol: SCCE | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 5650 | HGNC ID: HGNC:6368 | Ensembl Gene: ENSG00000169035 | OMIM ID: 604438 |
| Drug and gene relationship at DGIdb | |||
Expression of KLK7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLK7 | 5650 | 239381_at | -1.8504 | 0.2936 | |
| GSE20347 | KLK7 | 5650 | 205778_at | -1.8596 | 0.0002 | |
| GSE23400 | KLK7 | 5650 | 205778_at | -1.4442 | 0.0000 | |
| GSE26886 | KLK7 | 5650 | 239381_at | -2.8323 | 0.0001 | |
| GSE29001 | KLK7 | 5650 | 205778_at | -1.9141 | 0.0151 | |
| GSE38129 | KLK7 | 5650 | 205778_at | -0.9549 | 0.0878 | |
| GSE45670 | KLK7 | 5650 | 239381_at | 1.5645 | 0.0020 | |
| GSE53622 | KLK7 | 5650 | 5934 | -0.9408 | 0.0139 | |
| GSE53624 | KLK7 | 5650 | 5934 | -1.4760 | 0.0000 | |
| GSE63941 | KLK7 | 5650 | 239381_at | 1.4551 | 0.0758 | |
| GSE77861 | KLK7 | 5650 | 239381_at | -1.2595 | 0.1478 | |
| GSE97050 | KLK7 | 5650 | A_23_P39056 | 2.1589 | 0.0556 | |
| SRP007169 | KLK7 | 5650 | RNAseq | -2.1427 | 0.1793 | |
| SRP008496 | KLK7 | 5650 | RNAseq | -2.4878 | 0.0037 | |
| SRP064894 | KLK7 | 5650 | RNAseq | -2.0687 | 0.0001 | |
| SRP133303 | KLK7 | 5650 | RNAseq | -0.4800 | 0.2462 | |
| SRP159526 | KLK7 | 5650 | RNAseq | -2.1862 | 0.0007 | |
| SRP219564 | KLK7 | 5650 | RNAseq | -3.6398 | 0.0048 | |
| TCGA | KLK7 | 5650 | RNAseq | 1.0080 | 0.0039 |
Upregulated datasets: 2; Downregulated datasets: 9.
Survival by KLK7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLK7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLK7 | 5650 | 3 | 4 | 23 | |
| GSE20123 | KLK7 | 5650 | 3 | 3 | 24 | |
| GSE43470 | KLK7 | 5650 | 4 | 11 | 28 | |
| GSE46452 | KLK7 | 5650 | 45 | 1 | 13 | |
| GSE47630 | KLK7 | 5650 | 9 | 6 | 25 | |
| GSE54993 | KLK7 | 5650 | 17 | 4 | 49 | |
| GSE54994 | KLK7 | 5650 | 4 | 14 | 35 | |
| GSE60625 | KLK7 | 5650 | 9 | 0 | 2 | |
| GSE74703 | KLK7 | 5650 | 4 | 7 | 25 | |
| GSE74704 | KLK7 | 5650 | 3 | 1 | 16 | |
| TCGA | KLK7 | 5650 | 15 | 19 | 62 |
Total number of gains: 116; Total number of losses: 70; Total Number of normals: 302.
Somatic mutations of KLK7:
Generating mutation plots.
Highly correlated genes for KLK7:
Showing top 20/609 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLK7 | KLK8 | 0.783345 | 12 | 0 | 12 |
| KLK7 | KLK6 | 0.767804 | 13 | 0 | 11 |
| KLK7 | SPRR2A | 0.765115 | 4 | 0 | 4 |
| KLK7 | SPRR2E | 0.762344 | 4 | 0 | 4 |
| KLK7 | SPRR2D | 0.762034 | 4 | 0 | 4 |
| KLK7 | IL36RN | 0.755461 | 9 | 0 | 9 |
| KLK7 | SPRR2F | 0.743779 | 4 | 0 | 4 |
| KLK7 | SBSN | 0.743184 | 8 | 0 | 7 |
| KLK7 | CNFN | 0.732214 | 7 | 0 | 7 |
| KLK7 | DMKN | 0.728936 | 7 | 0 | 7 |
| KLK7 | IL36B | 0.727927 | 4 | 0 | 4 |
| KLK7 | KRTAP20-3 | 0.718088 | 3 | 0 | 3 |
| KLK7 | CYSRT1 | 0.716269 | 5 | 0 | 5 |
| KLK7 | KLK13 | 0.713146 | 12 | 0 | 11 |
| KLK7 | SLC5A1 | 0.709741 | 12 | 0 | 11 |
| KLK7 | SH3PXD2A-AS1 | 0.708284 | 3 | 0 | 3 |
| KLK7 | KRT6C | 0.70577 | 4 | 0 | 3 |
| KLK7 | KLK11 | 0.702329 | 12 | 0 | 11 |
| KLK7 | TGM1 | 0.701481 | 12 | 0 | 11 |
| KLK7 | IL1RN | 0.699953 | 12 | 0 | 12 |
For details and further investigation, click here
