| Full name: lebercilin LCA5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q14.1 | ||
| Entrez ID: 167691 | HGNC ID: HGNC:31923 | Ensembl Gene: ENSG00000135338 | OMIM ID: 611408 |
| Drug and gene relationship at DGIdb | |||
Expression of LCA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LCA5 | 167691 | 244401_at | -0.2228 | 0.3441 | |
| GSE26886 | LCA5 | 167691 | 244401_at | 0.0639 | 0.7147 | |
| GSE45670 | LCA5 | 167691 | 244401_at | -0.5385 | 0.0072 | |
| GSE53622 | LCA5 | 167691 | 28804 | -0.6898 | 0.0000 | |
| GSE53624 | LCA5 | 167691 | 28804 | -0.8632 | 0.0000 | |
| GSE63941 | LCA5 | 167691 | 244401_at | -0.2961 | 0.5463 | |
| GSE77861 | LCA5 | 167691 | 244401_at | 0.0050 | 0.9785 | |
| GSE97050 | LCA5 | 167691 | A_23_P418083 | -0.4387 | 0.1313 | |
| SRP007169 | LCA5 | 167691 | RNAseq | -0.5643 | 0.2907 | |
| SRP064894 | LCA5 | 167691 | RNAseq | -0.4594 | 0.1996 | |
| SRP133303 | LCA5 | 167691 | RNAseq | -0.3979 | 0.0329 | |
| SRP159526 | LCA5 | 167691 | RNAseq | -0.2822 | 0.4514 | |
| SRP193095 | LCA5 | 167691 | RNAseq | -0.3598 | 0.0947 | |
| SRP219564 | LCA5 | 167691 | RNAseq | -0.2197 | 0.7039 | |
| TCGA | LCA5 | 167691 | RNAseq | -0.0228 | 0.8483 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LCA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LCA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LCA5 | 167691 | 1 | 4 | 25 | |
| GSE20123 | LCA5 | 167691 | 1 | 3 | 26 | |
| GSE43470 | LCA5 | 167691 | 2 | 1 | 40 | |
| GSE46452 | LCA5 | 167691 | 3 | 11 | 45 | |
| GSE47630 | LCA5 | 167691 | 8 | 6 | 26 | |
| GSE54993 | LCA5 | 167691 | 3 | 2 | 65 | |
| GSE54994 | LCA5 | 167691 | 8 | 7 | 38 | |
| GSE60625 | LCA5 | 167691 | 0 | 1 | 10 | |
| GSE74703 | LCA5 | 167691 | 2 | 1 | 33 | |
| GSE74704 | LCA5 | 167691 | 0 | 2 | 18 | |
| TCGA | LCA5 | 167691 | 6 | 21 | 69 |
Total number of gains: 34; Total number of losses: 59; Total Number of normals: 395.
Somatic mutations of LCA5:
Generating mutation plots.
Highly correlated genes for LCA5:
Showing top 20/339 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LCA5 | SEC16B | 0.792533 | 3 | 0 | 3 |
| LCA5 | TMEM30A | 0.751445 | 3 | 0 | 3 |
| LCA5 | MAGI1 | 0.725344 | 3 | 0 | 3 |
| LCA5 | GPRASP2 | 0.718281 | 3 | 0 | 3 |
| LCA5 | CSDE1 | 0.699408 | 3 | 0 | 3 |
| LCA5 | DNAJC21 | 0.698791 | 3 | 0 | 3 |
| LCA5 | EFHC1 | 0.696789 | 3 | 0 | 3 |
| LCA5 | DHX32 | 0.691296 | 3 | 0 | 3 |
| LCA5 | GEM | 0.690796 | 4 | 0 | 4 |
| LCA5 | NSRP1 | 0.690229 | 3 | 0 | 3 |
| LCA5 | BEX4 | 0.689981 | 5 | 0 | 5 |
| LCA5 | UFC1 | 0.689478 | 3 | 0 | 3 |
| LCA5 | HOXA3 | 0.688347 | 3 | 0 | 3 |
| LCA5 | RFX2 | 0.685646 | 4 | 0 | 3 |
| LCA5 | SLTM | 0.678281 | 4 | 0 | 4 |
| LCA5 | RALA | 0.676512 | 3 | 0 | 3 |
| LCA5 | SECISBP2L | 0.675535 | 4 | 0 | 4 |
| LCA5 | BMP2K | 0.672903 | 3 | 0 | 3 |
| LCA5 | SLC30A9 | 0.671951 | 5 | 0 | 5 |
| LCA5 | SMARCA2 | 0.671334 | 3 | 0 | 3 |
For details and further investigation, click here
