| Full name: patatin like phospholipase domain containing 6 | Alias Symbol: NTE|sws|iPLA2delta|SPG39 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 10908 | HGNC ID: HGNC:16268 | Ensembl Gene: ENSG00000032444 | OMIM ID: 603197 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PNPLA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PNPLA6 | 10908 | 203718_at | 0.5849 | 0.2090 | |
| GSE20347 | PNPLA6 | 10908 | 203718_at | -0.1579 | 0.2966 | |
| GSE23400 | PNPLA6 | 10908 | 203718_at | 0.0283 | 0.6891 | |
| GSE26886 | PNPLA6 | 10908 | 203718_at | -0.8566 | 0.0002 | |
| GSE29001 | PNPLA6 | 10908 | 203718_at | -0.3786 | 0.2670 | |
| GSE38129 | PNPLA6 | 10908 | 203718_at | -0.0680 | 0.5681 | |
| GSE45670 | PNPLA6 | 10908 | 203718_at | 0.2715 | 0.0248 | |
| GSE53622 | PNPLA6 | 10908 | 167977 | -0.2592 | 0.0032 | |
| GSE53624 | PNPLA6 | 10908 | 167977 | -0.0546 | 0.5120 | |
| GSE63941 | PNPLA6 | 10908 | 203718_at | 0.6797 | 0.0804 | |
| GSE77861 | PNPLA6 | 10908 | 203718_at | 0.0183 | 0.9503 | |
| GSE97050 | PNPLA6 | 10908 | A_23_P16166 | 0.2365 | 0.2901 | |
| SRP007169 | PNPLA6 | 10908 | RNAseq | -0.4160 | 0.3510 | |
| SRP008496 | PNPLA6 | 10908 | RNAseq | -0.7686 | 0.0084 | |
| SRP064894 | PNPLA6 | 10908 | RNAseq | 0.5245 | 0.0127 | |
| SRP133303 | PNPLA6 | 10908 | RNAseq | -0.1383 | 0.3704 | |
| SRP159526 | PNPLA6 | 10908 | RNAseq | -0.1020 | 0.6121 | |
| SRP193095 | PNPLA6 | 10908 | RNAseq | 0.0422 | 0.7460 | |
| SRP219564 | PNPLA6 | 10908 | RNAseq | 0.0731 | 0.7688 | |
| TCGA | PNPLA6 | 10908 | RNAseq | -0.0282 | 0.5537 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PNPLA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PNPLA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PNPLA6 | 10908 | 5 | 3 | 22 | |
| GSE20123 | PNPLA6 | 10908 | 4 | 2 | 24 | |
| GSE43470 | PNPLA6 | 10908 | 2 | 6 | 35 | |
| GSE46452 | PNPLA6 | 10908 | 47 | 1 | 11 | |
| GSE47630 | PNPLA6 | 10908 | 5 | 7 | 28 | |
| GSE54993 | PNPLA6 | 10908 | 16 | 3 | 51 | |
| GSE54994 | PNPLA6 | 10908 | 6 | 13 | 34 | |
| GSE60625 | PNPLA6 | 10908 | 9 | 0 | 2 | |
| GSE74703 | PNPLA6 | 10908 | 2 | 4 | 30 | |
| GSE74704 | PNPLA6 | 10908 | 1 | 2 | 17 | |
| TCGA | PNPLA6 | 10908 | 9 | 20 | 67 |
Total number of gains: 106; Total number of losses: 61; Total Number of normals: 321.
Somatic mutations of PNPLA6:
Generating mutation plots.
Highly correlated genes for PNPLA6:
Showing top 20/391 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PNPLA6 | KCTD15 | 0.781081 | 3 | 0 | 3 |
| PNPLA6 | LDLRAP1 | 0.778233 | 3 | 0 | 3 |
| PNPLA6 | UNC5B | 0.774745 | 3 | 0 | 3 |
| PNPLA6 | CUL7 | 0.767125 | 4 | 0 | 3 |
| PNPLA6 | KDM1B | 0.760119 | 3 | 0 | 3 |
| PNPLA6 | HLA-E | 0.744645 | 3 | 0 | 3 |
| PNPLA6 | HMBOX1 | 0.740427 | 3 | 0 | 3 |
| PNPLA6 | NDUFA11 | 0.73935 | 3 | 0 | 3 |
| PNPLA6 | PACS1 | 0.734562 | 4 | 0 | 3 |
| PNPLA6 | VPS37B | 0.733432 | 3 | 0 | 3 |
| PNPLA6 | CASKIN2 | 0.725131 | 4 | 0 | 4 |
| PNPLA6 | PUS7L | 0.721637 | 3 | 0 | 3 |
| PNPLA6 | CHD8 | 0.714479 | 3 | 0 | 3 |
| PNPLA6 | ZBTB39 | 0.708574 | 4 | 0 | 3 |
| PNPLA6 | CST2 | 0.705406 | 3 | 0 | 3 |
| PNPLA6 | SEC61A2 | 0.704373 | 3 | 0 | 3 |
| PNPLA6 | CSF2RA | 0.702003 | 3 | 0 | 3 |
| PNPLA6 | KEAP1 | 0.692693 | 4 | 0 | 4 |
| PNPLA6 | ARID1A | 0.690654 | 5 | 0 | 3 |
| PNPLA6 | MIF | 0.689001 | 5 | 0 | 5 |
For details and further investigation, click here
