| Full name: LEM domain containing 3 | Alias Symbol: MAN1 | ||
| Type: protein-coding gene | Cytoband: 12q14.3 | ||
| Entrez ID: 23592 | HGNC ID: HGNC:28887 | Ensembl Gene: ENSG00000174106 | OMIM ID: 607844 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LEMD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LEMD3 | 23592 | 218604_at | 0.2692 | 0.5115 | |
| GSE20347 | LEMD3 | 23592 | 218604_at | 0.2560 | 0.0270 | |
| GSE23400 | LEMD3 | 23592 | 218604_at | 0.1348 | 0.0077 | |
| GSE26886 | LEMD3 | 23592 | 218604_at | -0.2719 | 0.1090 | |
| GSE29001 | LEMD3 | 23592 | 218604_at | 0.3380 | 0.1276 | |
| GSE38129 | LEMD3 | 23592 | 218604_at | 0.2862 | 0.0059 | |
| GSE45670 | LEMD3 | 23592 | 218604_at | 0.0195 | 0.8247 | |
| GSE53622 | LEMD3 | 23592 | 54104 | 0.0396 | 0.5853 | |
| GSE53624 | LEMD3 | 23592 | 54104 | 0.1817 | 0.0089 | |
| GSE63941 | LEMD3 | 23592 | 218604_at | -0.3870 | 0.1863 | |
| GSE77861 | LEMD3 | 23592 | 218604_at | 0.4220 | 0.0332 | |
| GSE97050 | LEMD3 | 23592 | A_33_P3382709 | -0.0361 | 0.8864 | |
| SRP007169 | LEMD3 | 23592 | RNAseq | 1.0938 | 0.0036 | |
| SRP008496 | LEMD3 | 23592 | RNAseq | 1.2463 | 0.0000 | |
| SRP064894 | LEMD3 | 23592 | RNAseq | 0.1437 | 0.5707 | |
| SRP133303 | LEMD3 | 23592 | RNAseq | 0.8932 | 0.0050 | |
| SRP159526 | LEMD3 | 23592 | RNAseq | 0.4509 | 0.1655 | |
| SRP193095 | LEMD3 | 23592 | RNAseq | 0.1535 | 0.1120 | |
| SRP219564 | LEMD3 | 23592 | RNAseq | 0.3733 | 0.3835 | |
| TCGA | LEMD3 | 23592 | RNAseq | -0.0090 | 0.8785 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LEMD3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LEMD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LEMD3 | 23592 | 5 | 1 | 24 | |
| GSE20123 | LEMD3 | 23592 | 5 | 1 | 24 | |
| GSE43470 | LEMD3 | 23592 | 5 | 0 | 38 | |
| GSE46452 | LEMD3 | 23592 | 11 | 0 | 48 | |
| GSE47630 | LEMD3 | 23592 | 10 | 2 | 28 | |
| GSE54993 | LEMD3 | 23592 | 0 | 7 | 63 | |
| GSE54994 | LEMD3 | 23592 | 6 | 1 | 46 | |
| GSE60625 | LEMD3 | 23592 | 0 | 0 | 11 | |
| GSE74703 | LEMD3 | 23592 | 5 | 0 | 31 | |
| GSE74704 | LEMD3 | 23592 | 4 | 1 | 15 | |
| TCGA | LEMD3 | 23592 | 21 | 9 | 66 |
Total number of gains: 72; Total number of losses: 22; Total Number of normals: 394.
Somatic mutations of LEMD3:
Generating mutation plots.
Highly correlated genes for LEMD3:
Showing top 20/590 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LEMD3 | NAA30 | 0.76317 | 3 | 0 | 3 |
| LEMD3 | CPNE8 | 0.747806 | 3 | 0 | 3 |
| LEMD3 | THAP5 | 0.734575 | 3 | 0 | 3 |
| LEMD3 | LRRC34 | 0.722692 | 3 | 0 | 3 |
| LEMD3 | IWS1 | 0.722688 | 3 | 0 | 3 |
| LEMD3 | SDHB | 0.722631 | 3 | 0 | 3 |
| LEMD3 | GPR158 | 0.716906 | 3 | 0 | 3 |
| LEMD3 | ZDHHC7 | 0.711525 | 3 | 0 | 3 |
| LEMD3 | SESTD1 | 0.70938 | 3 | 0 | 3 |
| LEMD3 | THEM4 | 0.705881 | 3 | 0 | 3 |
| LEMD3 | CENPL | 0.704701 | 3 | 0 | 3 |
| LEMD3 | XPNPEP3 | 0.703478 | 4 | 0 | 3 |
| LEMD3 | ZNF395 | 0.699739 | 3 | 0 | 3 |
| LEMD3 | UBTD2 | 0.698188 | 3 | 0 | 3 |
| LEMD3 | CXCL5 | 0.697968 | 3 | 0 | 3 |
| LEMD3 | SIX4 | 0.697074 | 3 | 0 | 3 |
| LEMD3 | LMLN | 0.696421 | 3 | 0 | 3 |
| LEMD3 | TRIP4 | 0.695607 | 3 | 0 | 3 |
| LEMD3 | HPS3 | 0.695225 | 3 | 0 | 3 |
| LEMD3 | SNX30 | 0.693755 | 4 | 0 | 4 |
For details and further investigation, click here
