| Full name: LEO1 homolog, Paf1/RNA polymerase II complex component | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q21.2 | ||
| Entrez ID: 123169 | HGNC ID: HGNC:30401 | Ensembl Gene: ENSG00000166477 | OMIM ID: 610507 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of LEO1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LEO1 | 123169 | 235096_at | -0.1176 | 0.9099 | |
| GSE26886 | LEO1 | 123169 | 235096_at | -0.0612 | 0.7792 | |
| GSE45670 | LEO1 | 123169 | 235096_at | 0.2570 | 0.0420 | |
| GSE53622 | LEO1 | 123169 | 64424 | 0.0812 | 0.2866 | |
| GSE53624 | LEO1 | 123169 | 44096 | -0.1127 | 0.0661 | |
| GSE63941 | LEO1 | 123169 | 235096_at | -0.3500 | 0.4334 | |
| GSE77861 | LEO1 | 123169 | 235096_at | 0.1172 | 0.6042 | |
| GSE97050 | LEO1 | 123169 | A_23_P314222 | 0.0529 | 0.8890 | |
| SRP007169 | LEO1 | 123169 | RNAseq | 1.0088 | 0.1955 | |
| SRP064894 | LEO1 | 123169 | RNAseq | -0.1509 | 0.3322 | |
| SRP133303 | LEO1 | 123169 | RNAseq | 0.0158 | 0.9271 | |
| SRP159526 | LEO1 | 123169 | RNAseq | -0.2519 | 0.5460 | |
| SRP193095 | LEO1 | 123169 | RNAseq | -0.1194 | 0.3037 | |
| SRP219564 | LEO1 | 123169 | RNAseq | -0.1947 | 0.6474 | |
| TCGA | LEO1 | 123169 | RNAseq | 0.1731 | 0.0032 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LEO1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LEO1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LEO1 | 123169 | 5 | 4 | 21 | |
| GSE20123 | LEO1 | 123169 | 5 | 4 | 21 | |
| GSE43470 | LEO1 | 123169 | 4 | 3 | 36 | |
| GSE46452 | LEO1 | 123169 | 3 | 7 | 49 | |
| GSE47630 | LEO1 | 123169 | 8 | 10 | 22 | |
| GSE54993 | LEO1 | 123169 | 5 | 6 | 59 | |
| GSE54994 | LEO1 | 123169 | 5 | 7 | 41 | |
| GSE60625 | LEO1 | 123169 | 4 | 0 | 7 | |
| GSE74703 | LEO1 | 123169 | 4 | 2 | 30 | |
| GSE74704 | LEO1 | 123169 | 2 | 3 | 15 | |
| TCGA | LEO1 | 123169 | 9 | 17 | 70 |
Total number of gains: 54; Total number of losses: 63; Total Number of normals: 371.
Somatic mutations of LEO1:
Generating mutation plots.
Highly correlated genes for LEO1:
Showing top 20/155 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LEO1 | MCTP2 | 0.719417 | 3 | 0 | 3 |
| LEO1 | GNAI3 | 0.712526 | 3 | 0 | 3 |
| LEO1 | NAA40 | 0.683081 | 3 | 0 | 3 |
| LEO1 | SNRPF | 0.670729 | 3 | 0 | 3 |
| LEO1 | MREG | 0.669874 | 4 | 0 | 3 |
| LEO1 | MAPK6 | 0.669812 | 7 | 0 | 6 |
| LEO1 | HPSE | 0.66948 | 4 | 0 | 3 |
| LEO1 | ALAS1 | 0.668931 | 4 | 0 | 3 |
| LEO1 | NAE1 | 0.663065 | 3 | 0 | 3 |
| LEO1 | ALDH1A3 | 0.662098 | 3 | 0 | 3 |
| LEO1 | DCTN5 | 0.658972 | 3 | 0 | 3 |
| LEO1 | DCTD | 0.658751 | 3 | 0 | 3 |
| LEO1 | TRMT1L | 0.657172 | 3 | 0 | 3 |
| LEO1 | ALDH3B2 | 0.655781 | 3 | 0 | 3 |
| LEO1 | PLS3 | 0.65534 | 4 | 0 | 3 |
| LEO1 | PHLDA1 | 0.646635 | 3 | 0 | 3 |
| LEO1 | TMEM54 | 0.646517 | 4 | 0 | 3 |
| LEO1 | CIAPIN1 | 0.646269 | 4 | 0 | 3 |
| LEO1 | KCMF1 | 0.641815 | 4 | 0 | 3 |
| LEO1 | TXNDC9 | 0.639468 | 4 | 0 | 3 |
For details and further investigation, click here
