| Full name: growth differentiation factor 15 | Alias Symbol: PLAB|MIC-1|PDF|MIC1|NAG-1|PTGFB | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 9518 | HGNC ID: HGNC:30142 | Ensembl Gene: ENSG00000130513 | OMIM ID: 605312 |
| Drug and gene relationship at DGIdb | |||
Expression of GDF15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GDF15 | 9518 | 221577_x_at | 0.1632 | 0.8680 | |
| GSE20347 | GDF15 | 9518 | 221577_x_at | 0.6860 | 0.0702 | |
| GSE23400 | GDF15 | 9518 | 221577_x_at | 0.0741 | 0.5482 | |
| GSE26886 | GDF15 | 9518 | 221577_x_at | 1.0375 | 0.0002 | |
| GSE29001 | GDF15 | 9518 | 221577_x_at | 0.3117 | 0.3245 | |
| GSE38129 | GDF15 | 9518 | 221577_x_at | 0.9282 | 0.0068 | |
| GSE45670 | GDF15 | 9518 | 221577_x_at | 1.0672 | 0.0097 | |
| GSE53622 | GDF15 | 9518 | 53768 | 0.4703 | 0.0001 | |
| GSE53624 | GDF15 | 9518 | 53768 | 0.7943 | 0.0000 | |
| GSE63941 | GDF15 | 9518 | 221577_x_at | -0.3161 | 0.8641 | |
| GSE77861 | GDF15 | 9518 | 221577_x_at | 0.5762 | 0.2356 | |
| GSE97050 | GDF15 | 9518 | A_23_P16523 | 0.3976 | 0.2976 | |
| SRP133303 | GDF15 | 9518 | RNAseq | 2.9342 | 0.0000 | |
| SRP159526 | GDF15 | 9518 | RNAseq | 1.4414 | 0.0004 | |
| SRP219564 | GDF15 | 9518 | RNAseq | 1.6641 | 0.0713 | |
| TCGA | GDF15 | 9518 | RNAseq | -0.4515 | 0.0719 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by GDF15 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GDF15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GDF15 | 9518 | 4 | 4 | 22 | |
| GSE20123 | GDF15 | 9518 | 3 | 2 | 25 | |
| GSE43470 | GDF15 | 9518 | 2 | 5 | 36 | |
| GSE46452 | GDF15 | 9518 | 47 | 1 | 11 | |
| GSE47630 | GDF15 | 9518 | 4 | 8 | 28 | |
| GSE54993 | GDF15 | 9518 | 15 | 4 | 51 | |
| GSE54994 | GDF15 | 9518 | 6 | 13 | 34 | |
| GSE60625 | GDF15 | 9518 | 9 | 0 | 2 | |
| GSE74703 | GDF15 | 9518 | 2 | 3 | 31 | |
| GSE74704 | GDF15 | 9518 | 0 | 2 | 18 | |
| TCGA | GDF15 | 9518 | 16 | 10 | 70 |
Total number of gains: 108; Total number of losses: 52; Total Number of normals: 328.
Somatic mutations of GDF15:
Generating mutation plots.
Highly correlated genes for GDF15:
Showing top 20/96 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GDF15 | MYO10 | 0.768231 | 3 | 0 | 3 |
| GDF15 | ZNF697 | 0.759915 | 3 | 0 | 3 |
| GDF15 | FAM110B | 0.723157 | 3 | 0 | 3 |
| GDF15 | ZNF511 | 0.720288 | 3 | 0 | 3 |
| GDF15 | C8G | 0.708385 | 3 | 0 | 3 |
| GDF15 | LIF | 0.705864 | 4 | 0 | 4 |
| GDF15 | LAYN | 0.687925 | 3 | 0 | 3 |
| GDF15 | WNT9A | 0.685386 | 3 | 0 | 3 |
| GDF15 | TMCO3 | 0.679372 | 4 | 0 | 3 |
| GDF15 | GATA2 | 0.668412 | 3 | 0 | 3 |
| GDF15 | SOHLH1 | 0.662507 | 3 | 0 | 3 |
| GDF15 | NAT14 | 0.661164 | 4 | 0 | 3 |
| GDF15 | TRIM2 | 0.653421 | 3 | 0 | 3 |
| GDF15 | TSPYL6 | 0.652451 | 3 | 0 | 3 |
| GDF15 | LIG4 | 0.650391 | 3 | 0 | 3 |
| GDF15 | SYT1 | 0.647801 | 4 | 0 | 3 |
| GDF15 | KCNQ5 | 0.643319 | 3 | 0 | 3 |
| GDF15 | GNL1 | 0.641403 | 4 | 0 | 3 |
| GDF15 | FAM131A | 0.639511 | 5 | 0 | 5 |
| GDF15 | TBX2 | 0.636172 | 4 | 0 | 3 |
For details and further investigation, click here
