| Full name: Rho/Rac guanine nucleotide exchange factor 18 | Alias Symbol: P114-RhoGEF|KIAA0521|MGC15913|p114RhoGEF | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 23370 | HGNC ID: HGNC:17090 | Ensembl Gene: ENSG00000104880 | OMIM ID: 616432 |
| Drug and gene relationship at DGIdb | |||
Expression of ARHGEF18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF18 | 23370 | 213039_at | 0.2462 | 0.5813 | |
| GSE20347 | ARHGEF18 | 23370 | 213039_at | -0.2036 | 0.2031 | |
| GSE23400 | ARHGEF18 | 23370 | 213039_at | -0.3069 | 0.0002 | |
| GSE26886 | ARHGEF18 | 23370 | 213039_at | 0.1513 | 0.5684 | |
| GSE29001 | ARHGEF18 | 23370 | 213039_at | -0.3329 | 0.1532 | |
| GSE38129 | ARHGEF18 | 23370 | 213039_at | -0.1536 | 0.2886 | |
| GSE45670 | ARHGEF18 | 23370 | 213039_at | 0.3202 | 0.0042 | |
| GSE63941 | ARHGEF18 | 23370 | 213039_at | 0.6444 | 0.1087 | |
| GSE77861 | ARHGEF18 | 23370 | 213039_at | -0.2448 | 0.2903 | |
| GSE97050 | ARHGEF18 | 23370 | A_33_P3378915 | 0.2995 | 0.3701 | |
| SRP007169 | ARHGEF18 | 23370 | RNAseq | -1.2491 | 0.0106 | |
| SRP008496 | ARHGEF18 | 23370 | RNAseq | -1.2864 | 0.0000 | |
| SRP064894 | ARHGEF18 | 23370 | RNAseq | -0.3516 | 0.0071 | |
| SRP133303 | ARHGEF18 | 23370 | RNAseq | -0.2555 | 0.1860 | |
| SRP159526 | ARHGEF18 | 23370 | RNAseq | -0.8997 | 0.0000 | |
| SRP193095 | ARHGEF18 | 23370 | RNAseq | -0.3723 | 0.0247 | |
| SRP219564 | ARHGEF18 | 23370 | RNAseq | -0.4109 | 0.2002 | |
| TCGA | ARHGEF18 | 23370 | RNAseq | -0.1583 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ARHGEF18 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ARHGEF18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF18 | 23370 | 5 | 3 | 22 | |
| GSE20123 | ARHGEF18 | 23370 | 4 | 2 | 24 | |
| GSE43470 | ARHGEF18 | 23370 | 2 | 6 | 35 | |
| GSE46452 | ARHGEF18 | 23370 | 47 | 1 | 11 | |
| GSE47630 | ARHGEF18 | 23370 | 5 | 7 | 28 | |
| GSE54993 | ARHGEF18 | 23370 | 16 | 3 | 51 | |
| GSE54994 | ARHGEF18 | 23370 | 6 | 13 | 34 | |
| GSE60625 | ARHGEF18 | 23370 | 9 | 0 | 2 | |
| GSE74703 | ARHGEF18 | 23370 | 2 | 4 | 30 | |
| GSE74704 | ARHGEF18 | 23370 | 1 | 2 | 17 | |
| TCGA | ARHGEF18 | 23370 | 9 | 20 | 67 |
Total number of gains: 106; Total number of losses: 61; Total Number of normals: 321.
Somatic mutations of ARHGEF18:
Generating mutation plots.
Highly correlated genes for ARHGEF18:
Showing top 20/283 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF18 | ATP6V1A | 0.736784 | 3 | 0 | 3 |
| ARHGEF18 | XPNPEP1 | 0.704986 | 3 | 0 | 3 |
| ARHGEF18 | LASP1 | 0.693572 | 3 | 0 | 3 |
| ARHGEF18 | LPCAT3 | 0.687853 | 3 | 0 | 3 |
| ARHGEF18 | MED23 | 0.66407 | 3 | 0 | 3 |
| ARHGEF18 | LRG1 | 0.659748 | 3 | 0 | 3 |
| ARHGEF18 | HM13 | 0.65806 | 4 | 0 | 4 |
| ARHGEF18 | WIPF2 | 0.655474 | 4 | 0 | 3 |
| ARHGEF18 | P2RY2 | 0.654665 | 3 | 0 | 3 |
| ARHGEF18 | FAM83A | 0.654098 | 4 | 0 | 3 |
| ARHGEF18 | MIOS | 0.651266 | 3 | 0 | 3 |
| ARHGEF18 | AGPAT3 | 0.650167 | 3 | 0 | 3 |
| ARHGEF18 | ERCC2 | 0.648121 | 3 | 0 | 3 |
| ARHGEF18 | COPB2 | 0.64741 | 4 | 0 | 4 |
| ARHGEF18 | ITGAL | 0.64387 | 4 | 0 | 4 |
| ARHGEF18 | UBA1 | 0.640715 | 4 | 0 | 3 |
| ARHGEF18 | TRPC4AP | 0.640687 | 3 | 0 | 3 |
| ARHGEF18 | EIF6 | 0.63992 | 5 | 0 | 5 |
| ARHGEF18 | IL12RB1 | 0.638078 | 5 | 0 | 3 |
| ARHGEF18 | USP38 | 0.627885 | 3 | 0 | 3 |
For details and further investigation, click here
