| Full name: mitotic arrest deficient 1 like 1 | Alias Symbol: HsMAD1|TXBP181|MAD1|PIG9|TP53I9 | ||
| Type: protein-coding gene | Cytoband: 7p22.3 | ||
| Entrez ID: 8379 | HGNC ID: HGNC:6762 | Ensembl Gene: ENSG00000002822 | OMIM ID: 602686 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
MAD1L1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04914 | Progesterone-mediated oocyte maturation |
Expression of MAD1L1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAD1L1 | 8379 | 204857_at | 0.2804 | 0.5492 | |
| GSE20347 | MAD1L1 | 8379 | 204857_at | 0.3172 | 0.1273 | |
| GSE23400 | MAD1L1 | 8379 | 204857_at | 0.4912 | 0.0000 | |
| GSE26886 | MAD1L1 | 8379 | 204857_at | 0.7107 | 0.0109 | |
| GSE29001 | MAD1L1 | 8379 | 204857_at | 0.1944 | 0.6041 | |
| GSE38129 | MAD1L1 | 8379 | 204857_at | 0.6289 | 0.0035 | |
| GSE45670 | MAD1L1 | 8379 | 204857_at | 0.4995 | 0.1711 | |
| GSE53622 | MAD1L1 | 8379 | 22633 | 0.9106 | 0.0000 | |
| GSE53624 | MAD1L1 | 8379 | 22633 | 0.7712 | 0.0000 | |
| GSE63941 | MAD1L1 | 8379 | 204857_at | 1.7112 | 0.0075 | |
| GSE77861 | MAD1L1 | 8379 | 204857_at | 0.3560 | 0.0262 | |
| GSE97050 | MAD1L1 | 8379 | A_33_P3569068 | 0.8045 | 0.2757 | |
| SRP007169 | MAD1L1 | 8379 | RNAseq | 0.6038 | 0.2898 | |
| SRP008496 | MAD1L1 | 8379 | RNAseq | 1.0014 | 0.0071 | |
| SRP064894 | MAD1L1 | 8379 | RNAseq | 1.1845 | 0.0001 | |
| SRP133303 | MAD1L1 | 8379 | RNAseq | 0.6577 | 0.0005 | |
| SRP159526 | MAD1L1 | 8379 | RNAseq | 0.3797 | 0.2726 | |
| SRP193095 | MAD1L1 | 8379 | RNAseq | 0.7701 | 0.0000 | |
| SRP219564 | MAD1L1 | 8379 | RNAseq | 0.5556 | 0.0626 | |
| TCGA | MAD1L1 | 8379 | RNAseq | 0.2496 | 0.0004 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by MAD1L1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAD1L1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAD1L1 | 8379 | 14 | 0 | 16 | |
| GSE20123 | MAD1L1 | 8379 | 14 | 0 | 16 | |
| GSE43470 | MAD1L1 | 8379 | 6 | 3 | 34 | |
| GSE46452 | MAD1L1 | 8379 | 13 | 1 | 45 | |
| GSE47630 | MAD1L1 | 8379 | 10 | 1 | 29 | |
| GSE54993 | MAD1L1 | 8379 | 0 | 7 | 63 | |
| GSE54994 | MAD1L1 | 8379 | 19 | 3 | 31 | |
| GSE60625 | MAD1L1 | 8379 | 0 | 0 | 11 | |
| GSE74703 | MAD1L1 | 8379 | 6 | 2 | 28 | |
| GSE74704 | MAD1L1 | 8379 | 9 | 0 | 11 | |
| TCGA | MAD1L1 | 8379 | 56 | 6 | 34 |
Total number of gains: 147; Total number of losses: 23; Total Number of normals: 318.
Somatic mutations of MAD1L1:
Generating mutation plots.
Highly correlated genes for MAD1L1:
Showing top 20/434 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAD1L1 | KRTCAP3 | 0.710057 | 3 | 0 | 3 |
| MAD1L1 | TMC8 | 0.671475 | 3 | 0 | 3 |
| MAD1L1 | EIF3B | 0.653952 | 12 | 0 | 11 |
| MAD1L1 | YDJC | 0.645746 | 5 | 0 | 5 |
| MAD1L1 | HM13 | 0.636863 | 3 | 0 | 3 |
| MAD1L1 | SDCCAG8 | 0.632191 | 3 | 0 | 3 |
| MAD1L1 | DCBLD1 | 0.625596 | 6 | 0 | 5 |
| MAD1L1 | SLC19A1 | 0.623388 | 3 | 0 | 3 |
| MAD1L1 | PIGX | 0.620637 | 4 | 0 | 4 |
| MAD1L1 | RAD23A | 0.619331 | 3 | 0 | 3 |
| MAD1L1 | BOP1 | 0.617416 | 3 | 0 | 3 |
| MAD1L1 | CLSPN | 0.615832 | 6 | 0 | 5 |
| MAD1L1 | CPOX | 0.615149 | 3 | 0 | 3 |
| MAD1L1 | FAM220A | 0.608798 | 7 | 0 | 5 |
| MAD1L1 | NLK | 0.608049 | 3 | 0 | 3 |
| MAD1L1 | LPAR2 | 0.606481 | 5 | 0 | 3 |
| MAD1L1 | LSM8 | 0.604172 | 3 | 0 | 3 |
| MAD1L1 | THOC6 | 0.600758 | 8 | 0 | 7 |
| MAD1L1 | ZDHHC8 | 0.600248 | 3 | 0 | 3 |
| MAD1L1 | ZNF488 | 0.599548 | 5 | 0 | 3 |
For details and further investigation, click here
