| Full name: mitogen-activated protein kinase kinase kinase 12 | Alias Symbol: MUK|DLK|ZPKP1|MEKK12 | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 7786 | HGNC ID: HGNC:6851 | Ensembl Gene: ENSG00000139625 | OMIM ID: 600447 |
| Drug and gene relationship at DGIdb | |||
MAP3K12 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of MAP3K12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAP3K12 | 7786 | 205448_s_at | -0.2093 | 0.5207 | |
| GSE20347 | MAP3K12 | 7786 | 205448_s_at | -0.0665 | 0.3707 | |
| GSE23400 | MAP3K12 | 7786 | 205448_s_at | -0.0636 | 0.1581 | |
| GSE26886 | MAP3K12 | 7786 | 205448_s_at | 0.0039 | 0.9818 | |
| GSE29001 | MAP3K12 | 7786 | 205448_s_at | -0.0032 | 0.9874 | |
| GSE38129 | MAP3K12 | 7786 | 205448_s_at | -0.2244 | 0.0185 | |
| GSE45670 | MAP3K12 | 7786 | 205448_s_at | -0.2110 | 0.1135 | |
| GSE53622 | MAP3K12 | 7786 | 14835 | 0.1105 | 0.1488 | |
| GSE53624 | MAP3K12 | 7786 | 14835 | 0.2962 | 0.0000 | |
| GSE63941 | MAP3K12 | 7786 | 205448_s_at | 0.0407 | 0.9332 | |
| GSE77861 | MAP3K12 | 7786 | 205448_s_at | -0.0017 | 0.9921 | |
| GSE97050 | MAP3K12 | 7786 | A_23_P105409 | 0.1150 | 0.6856 | |
| SRP007169 | MAP3K12 | 7786 | RNAseq | 1.2278 | 0.0621 | |
| SRP064894 | MAP3K12 | 7786 | RNAseq | 0.6546 | 0.0296 | |
| SRP133303 | MAP3K12 | 7786 | RNAseq | -0.0597 | 0.6940 | |
| SRP159526 | MAP3K12 | 7786 | RNAseq | 0.2709 | 0.4582 | |
| SRP193095 | MAP3K12 | 7786 | RNAseq | 0.8515 | 0.0000 | |
| SRP219564 | MAP3K12 | 7786 | RNAseq | 0.4146 | 0.3815 | |
| TCGA | MAP3K12 | 7786 | RNAseq | -0.1118 | 0.3338 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MAP3K12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAP3K12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAP3K12 | 7786 | 7 | 1 | 22 | |
| GSE20123 | MAP3K12 | 7786 | 7 | 1 | 22 | |
| GSE43470 | MAP3K12 | 7786 | 3 | 0 | 40 | |
| GSE46452 | MAP3K12 | 7786 | 7 | 1 | 51 | |
| GSE47630 | MAP3K12 | 7786 | 10 | 2 | 28 | |
| GSE54993 | MAP3K12 | 7786 | 0 | 5 | 65 | |
| GSE54994 | MAP3K12 | 7786 | 4 | 1 | 48 | |
| GSE60625 | MAP3K12 | 7786 | 0 | 0 | 11 | |
| GSE74703 | MAP3K12 | 7786 | 3 | 0 | 33 | |
| GSE74704 | MAP3K12 | 7786 | 5 | 1 | 14 | |
| TCGA | MAP3K12 | 7786 | 14 | 11 | 71 |
Total number of gains: 60; Total number of losses: 23; Total Number of normals: 405.
Somatic mutations of MAP3K12:
Generating mutation plots.
Highly correlated genes for MAP3K12:
Showing top 20/193 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAP3K12 | GPR21 | 0.692781 | 3 | 0 | 3 |
| MAP3K12 | STK32B | 0.67372 | 4 | 0 | 4 |
| MAP3K12 | ANO7 | 0.667439 | 3 | 0 | 3 |
| MAP3K12 | STAT5B | 0.640874 | 4 | 0 | 3 |
| MAP3K12 | OSM | 0.63525 | 3 | 0 | 3 |
| MAP3K12 | RAB4B | 0.623574 | 3 | 0 | 3 |
| MAP3K12 | ADCY4 | 0.619157 | 4 | 0 | 4 |
| MAP3K12 | GJA4 | 0.619156 | 6 | 0 | 5 |
| MAP3K12 | S1PR1 | 0.617937 | 4 | 0 | 3 |
| MAP3K12 | SVEP1 | 0.616627 | 4 | 0 | 4 |
| MAP3K12 | SERPINA5 | 0.614386 | 4 | 0 | 3 |
| MAP3K12 | HRH2 | 0.61422 | 5 | 0 | 3 |
| MAP3K12 | APBB1 | 0.611868 | 5 | 0 | 3 |
| MAP3K12 | TEK | 0.61037 | 4 | 0 | 3 |
| MAP3K12 | VSTM4 | 0.607139 | 5 | 0 | 3 |
| MAP3K12 | PARM1 | 0.606752 | 3 | 0 | 3 |
| MAP3K12 | SHH | 0.60666 | 4 | 0 | 3 |
| MAP3K12 | FRRS1L | 0.604674 | 3 | 0 | 3 |
| MAP3K12 | ARHGAP24 | 0.604634 | 4 | 0 | 4 |
| MAP3K12 | RAMP3 | 0.603498 | 7 | 0 | 5 |
For details and further investigation, click here
