| Full name: methionyl aminopeptidase 1 | Alias Symbol: KIAA0094|MetAP1A|MAP1A | ||
| Type: protein-coding gene | Cytoband: 4q23 | ||
| Entrez ID: 23173 | HGNC ID: HGNC:15789 | Ensembl Gene: ENSG00000164024 | OMIM ID: 610151 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of METAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | METAP1 | 23173 | 212673_at | 0.0915 | 0.8676 | |
| GSE20347 | METAP1 | 23173 | 212673_at | -0.3373 | 0.0023 | |
| GSE23400 | METAP1 | 23173 | 212673_at | -0.0673 | 0.3336 | |
| GSE26886 | METAP1 | 23173 | 212673_at | -1.0885 | 0.0000 | |
| GSE29001 | METAP1 | 23173 | 212673_at | -0.3853 | 0.1086 | |
| GSE38129 | METAP1 | 23173 | 212673_at | -0.0081 | 0.9703 | |
| GSE45670 | METAP1 | 23173 | 212673_at | -0.2464 | 0.0731 | |
| GSE53622 | METAP1 | 23173 | 49602 | -0.3011 | 0.0002 | |
| GSE53624 | METAP1 | 23173 | 49602 | -0.3644 | 0.0000 | |
| GSE63941 | METAP1 | 23173 | 212673_at | 0.7164 | 0.0510 | |
| GSE77861 | METAP1 | 23173 | 212673_at | -0.2566 | 0.2285 | |
| GSE97050 | METAP1 | 23173 | A_23_P155907 | -0.0717 | 0.7983 | |
| SRP007169 | METAP1 | 23173 | RNAseq | 0.0247 | 0.9453 | |
| SRP008496 | METAP1 | 23173 | RNAseq | -0.0608 | 0.8016 | |
| SRP064894 | METAP1 | 23173 | RNAseq | -0.5404 | 0.0092 | |
| SRP133303 | METAP1 | 23173 | RNAseq | -0.2322 | 0.1396 | |
| SRP159526 | METAP1 | 23173 | RNAseq | -0.6860 | 0.0234 | |
| SRP193095 | METAP1 | 23173 | RNAseq | -0.5342 | 0.0008 | |
| SRP219564 | METAP1 | 23173 | RNAseq | -0.6758 | 0.0765 | |
| TCGA | METAP1 | 23173 | RNAseq | 0.1706 | 0.0006 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by METAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of METAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | METAP1 | 23173 | 0 | 13 | 17 | |
| GSE20123 | METAP1 | 23173 | 0 | 13 | 17 | |
| GSE43470 | METAP1 | 23173 | 0 | 14 | 29 | |
| GSE46452 | METAP1 | 23173 | 1 | 36 | 22 | |
| GSE47630 | METAP1 | 23173 | 0 | 20 | 20 | |
| GSE54993 | METAP1 | 23173 | 9 | 0 | 61 | |
| GSE54994 | METAP1 | 23173 | 1 | 11 | 41 | |
| GSE60625 | METAP1 | 23173 | 0 | 3 | 8 | |
| GSE74703 | METAP1 | 23173 | 0 | 12 | 24 | |
| GSE74704 | METAP1 | 23173 | 0 | 6 | 14 | |
| TCGA | METAP1 | 23173 | 8 | 41 | 47 |
Total number of gains: 19; Total number of losses: 169; Total Number of normals: 300.
Somatic mutations of METAP1:
Generating mutation plots.
Highly correlated genes for METAP1:
Showing top 20/1181 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| METAP1 | ZNF416 | 0.792163 | 4 | 0 | 4 |
| METAP1 | PLEKHM2 | 0.74966 | 3 | 0 | 3 |
| METAP1 | MKRN1 | 0.743297 | 3 | 0 | 3 |
| METAP1 | LCOR | 0.737373 | 3 | 0 | 3 |
| METAP1 | MTA3 | 0.726649 | 3 | 0 | 3 |
| METAP1 | ANKRD28 | 0.720727 | 3 | 0 | 3 |
| METAP1 | CIAPIN1 | 0.713546 | 4 | 0 | 4 |
| METAP1 | FBXO9 | 0.713134 | 4 | 0 | 4 |
| METAP1 | ANAPC16 | 0.710329 | 3 | 0 | 3 |
| METAP1 | ZNF217 | 0.706023 | 5 | 0 | 5 |
| METAP1 | CNOT11 | 0.701463 | 3 | 0 | 3 |
| METAP1 | ABHD12 | 0.699302 | 5 | 0 | 4 |
| METAP1 | BROX | 0.698621 | 4 | 0 | 4 |
| METAP1 | MBOAT1 | 0.697363 | 4 | 0 | 3 |
| METAP1 | CGNL1 | 0.697262 | 3 | 0 | 3 |
| METAP1 | GOLGA4 | 0.694407 | 5 | 0 | 5 |
| METAP1 | TET2 | 0.693908 | 7 | 0 | 5 |
| METAP1 | WWP1 | 0.693357 | 4 | 0 | 4 |
| METAP1 | TMEM120A | 0.692241 | 5 | 0 | 4 |
| METAP1 | ZRANB2 | 0.690404 | 3 | 0 | 3 |
For details and further investigation, click here
