| Full name: spindle and kinetochore associated complex subunit 1 | Alias Symbol: MGC10200 | ||
| Type: protein-coding gene | Cytoband: 18q21.1 | ||
| Entrez ID: 220134 | HGNC ID: HGNC:28109 | Ensembl Gene: ENSG00000154839 | OMIM ID: 616673 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SKA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SKA1 | 220134 | 217640_x_at | 0.9108 | 0.1310 | |
| GSE20347 | SKA1 | 220134 | 217640_x_at | 0.6408 | 0.0000 | |
| GSE23400 | SKA1 | 220134 | 217640_x_at | 0.1742 | 0.0000 | |
| GSE26886 | SKA1 | 220134 | 217640_x_at | 0.2808 | 0.0298 | |
| GSE29001 | SKA1 | 220134 | 217640_x_at | 0.3739 | 0.0032 | |
| GSE38129 | SKA1 | 220134 | 217640_x_at | 0.9627 | 0.0000 | |
| GSE45670 | SKA1 | 220134 | 217640_x_at | 1.0975 | 0.0000 | |
| GSE53622 | SKA1 | 220134 | 20730 | 1.4906 | 0.0000 | |
| GSE53624 | SKA1 | 220134 | 20730 | 1.8550 | 0.0000 | |
| GSE63941 | SKA1 | 220134 | 217640_x_at | 1.5671 | 0.0092 | |
| GSE77861 | SKA1 | 220134 | 217640_x_at | 0.4472 | 0.0029 | |
| GSE97050 | SKA1 | 220134 | A_24_P322354 | 1.1450 | 0.0625 | |
| SRP007169 | SKA1 | 220134 | RNAseq | 1.1269 | 0.0022 | |
| SRP008496 | SKA1 | 220134 | RNAseq | 1.5671 | 0.0040 | |
| SRP064894 | SKA1 | 220134 | RNAseq | 1.3825 | 0.0000 | |
| SRP133303 | SKA1 | 220134 | RNAseq | 0.8518 | 0.0003 | |
| SRP159526 | SKA1 | 220134 | RNAseq | 1.4738 | 0.0001 | |
| SRP193095 | SKA1 | 220134 | RNAseq | 0.7016 | 0.0000 | |
| SRP219564 | SKA1 | 220134 | RNAseq | 1.2045 | 0.0621 | |
| TCGA | SKA1 | 220134 | RNAseq | 1.4884 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by SKA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SKA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SKA1 | 220134 | 1 | 9 | 20 | |
| GSE20123 | SKA1 | 220134 | 1 | 9 | 20 | |
| GSE43470 | SKA1 | 220134 | 0 | 4 | 39 | |
| GSE46452 | SKA1 | 220134 | 1 | 26 | 32 | |
| GSE47630 | SKA1 | 220134 | 5 | 20 | 15 | |
| GSE54993 | SKA1 | 220134 | 9 | 0 | 61 | |
| GSE54994 | SKA1 | 220134 | 1 | 17 | 35 | |
| GSE60625 | SKA1 | 220134 | 0 | 4 | 7 | |
| GSE74703 | SKA1 | 220134 | 0 | 4 | 32 | |
| GSE74704 | SKA1 | 220134 | 1 | 6 | 13 | |
| TCGA | SKA1 | 220134 | 9 | 44 | 43 |
Total number of gains: 28; Total number of losses: 143; Total Number of normals: 317.
Somatic mutations of SKA1:
Generating mutation plots.
Highly correlated genes for SKA1:
Showing top 20/2060 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SKA1 | DKC1 | 0.789494 | 3 | 0 | 3 |
| SKA1 | MMS22L | 0.786872 | 3 | 0 | 3 |
| SKA1 | KNSTRN | 0.784308 | 7 | 0 | 7 |
| SKA1 | ZNF707 | 0.773464 | 3 | 0 | 3 |
| SKA1 | KIF14 | 0.773082 | 12 | 0 | 12 |
| SKA1 | TIMELESS | 0.767147 | 11 | 0 | 11 |
| SKA1 | CENPW | 0.763414 | 8 | 0 | 8 |
| SKA1 | HJURP | 0.761681 | 12 | 0 | 11 |
| SKA1 | CDT1 | 0.761529 | 12 | 0 | 11 |
| SKA1 | UBE2T | 0.758843 | 9 | 0 | 8 |
| SKA1 | BUB1 | 0.758804 | 12 | 0 | 10 |
| SKA1 | BIRC5 | 0.758524 | 12 | 0 | 11 |
| SKA1 | KIF15 | 0.758481 | 11 | 0 | 10 |
| SKA1 | NCAPH | 0.757897 | 9 | 0 | 8 |
| SKA1 | EBNA1BP2 | 0.757707 | 3 | 0 | 3 |
| SKA1 | IRF2BPL | 0.756526 | 3 | 0 | 3 |
| SKA1 | CDCA2 | 0.75563 | 7 | 0 | 6 |
| SKA1 | CCNB2 | 0.755591 | 12 | 0 | 11 |
| SKA1 | CEP55 | 0.754227 | 13 | 0 | 12 |
| SKA1 | PSMG3 | 0.753497 | 6 | 0 | 6 |
For details and further investigation, click here
