| Full name: MLX interacting protein | Alias Symbol: MONDOA|KIAA0867|MIR|bHLHe36 | ||
| Type: protein-coding gene | Cytoband: 12q21.31 | ||
| Entrez ID: 22877 | HGNC ID: HGNC:17055 | Ensembl Gene: ENSG00000175727 | OMIM ID: 608090 |
| Drug and gene relationship at DGIdb | |||
MLXIP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04931 | Insulin resistance | |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) |
Expression of MLXIP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MLXIP | 22877 | 202519_at | 0.3814 | 0.5355 | |
| GSE20347 | MLXIP | 22877 | 202519_at | 0.4958 | 0.0032 | |
| GSE23400 | MLXIP | 22877 | 202519_at | 0.0247 | 0.8289 | |
| GSE26886 | MLXIP | 22877 | 202519_at | -0.7320 | 0.0070 | |
| GSE29001 | MLXIP | 22877 | 202519_at | 0.3312 | 0.3072 | |
| GSE38129 | MLXIP | 22877 | 202519_at | 0.1510 | 0.5409 | |
| GSE45670 | MLXIP | 22877 | 225157_at | -0.2379 | 0.1614 | |
| GSE53622 | MLXIP | 22877 | 67386 | 0.0740 | 0.4895 | |
| GSE53624 | MLXIP | 22877 | 67386 | 0.1457 | 0.0362 | |
| GSE63941 | MLXIP | 22877 | 225157_at | -1.6054 | 0.0011 | |
| GSE77861 | MLXIP | 22877 | 225157_at | 0.4636 | 0.0607 | |
| GSE97050 | MLXIP | 22877 | A_24_P415624 | -0.0472 | 0.8608 | |
| SRP007169 | MLXIP | 22877 | RNAseq | 0.7468 | 0.0781 | |
| SRP008496 | MLXIP | 22877 | RNAseq | 0.4121 | 0.0994 | |
| SRP064894 | MLXIP | 22877 | RNAseq | 0.2578 | 0.2461 | |
| SRP133303 | MLXIP | 22877 | RNAseq | 0.1756 | 0.3288 | |
| SRP159526 | MLXIP | 22877 | RNAseq | 0.3291 | 0.3293 | |
| SRP193095 | MLXIP | 22877 | RNAseq | 0.3870 | 0.0641 | |
| SRP219564 | MLXIP | 22877 | RNAseq | 0.0480 | 0.9234 | |
| TCGA | MLXIP | 22877 | RNAseq | -0.2551 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MLXIP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MLXIP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MLXIP | 22877 | 5 | 4 | 21 | |
| GSE20123 | MLXIP | 22877 | 5 | 4 | 21 | |
| GSE43470 | MLXIP | 22877 | 2 | 2 | 39 | |
| GSE46452 | MLXIP | 22877 | 9 | 1 | 49 | |
| GSE47630 | MLXIP | 22877 | 9 | 3 | 28 | |
| GSE54993 | MLXIP | 22877 | 0 | 5 | 65 | |
| GSE54994 | MLXIP | 22877 | 5 | 7 | 41 | |
| GSE60625 | MLXIP | 22877 | 0 | 0 | 11 | |
| GSE74703 | MLXIP | 22877 | 2 | 1 | 33 | |
| GSE74704 | MLXIP | 22877 | 4 | 2 | 14 | |
| TCGA | MLXIP | 22877 | 21 | 10 | 65 |
Total number of gains: 62; Total number of losses: 39; Total Number of normals: 387.
Somatic mutations of MLXIP:
Generating mutation plots.
Highly correlated genes for MLXIP:
Showing top 20/408 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MLXIP | NBPF20 | 0.751873 | 3 | 0 | 3 |
| MLXIP | ITPRIPL2 | 0.708718 | 3 | 0 | 3 |
| MLXIP | PIEZO1 | 0.701939 | 4 | 0 | 4 |
| MLXIP | ZNF746 | 0.692453 | 3 | 0 | 3 |
| MLXIP | TMSB10 | 0.684758 | 3 | 0 | 3 |
| MLXIP | VCAM1 | 0.679221 | 4 | 0 | 4 |
| MLXIP | CHST14 | 0.676783 | 3 | 0 | 3 |
| MLXIP | ANKS3 | 0.670064 | 4 | 0 | 3 |
| MLXIP | SMARCD2 | 0.669463 | 3 | 0 | 3 |
| MLXIP | SLC35B3 | 0.669295 | 3 | 0 | 3 |
| MLXIP | CCL11 | 0.665933 | 3 | 0 | 3 |
| MLXIP | OSR1 | 0.651155 | 4 | 0 | 3 |
| MLXIP | NCOR2 | 0.645942 | 7 | 0 | 6 |
| MLXIP | ALKBH5 | 0.641318 | 3 | 0 | 3 |
| MLXIP | KPNA6 | 0.64053 | 4 | 0 | 4 |
| MLXIP | ADAMTS1 | 0.639534 | 6 | 0 | 5 |
| MLXIP | CD81 | 0.638239 | 9 | 0 | 8 |
| MLXIP | CLIC6 | 0.635883 | 3 | 0 | 3 |
| MLXIP | IL13RA2 | 0.629 | 4 | 0 | 3 |
| MLXIP | MFAP4 | 0.628608 | 5 | 0 | 4 |
For details and further investigation, click here
