| Full name: RAS guanyl releasing protein 1 | Alias Symbol: CalDAG-GEFII|RASGRP | ||
| Type: protein-coding gene | Cytoband: 15q14 | ||
| Entrez ID: 10125 | HGNC ID: HGNC:9878 | Ensembl Gene: ENSG00000172575 | OMIM ID: 603962 |
| Drug and gene relationship at DGIdb | |||
RASGRP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04014 | Ras signaling pathway | |
| hsa04611 | Platelet activation | |
| hsa04660 | T cell receptor signaling pathway |
Expression of RASGRP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RASGRP1 | 10125 | 205590_at | -0.1236 | 0.9386 | |
| GSE20347 | RASGRP1 | 10125 | 205590_at | -1.0444 | 0.0106 | |
| GSE23400 | RASGRP1 | 10125 | 205590_at | -0.5519 | 0.0000 | |
| GSE26886 | RASGRP1 | 10125 | 205590_at | -2.2790 | 0.0000 | |
| GSE29001 | RASGRP1 | 10125 | 205590_at | -1.3667 | 0.0084 | |
| GSE38129 | RASGRP1 | 10125 | 205590_at | -0.6327 | 0.1146 | |
| GSE45670 | RASGRP1 | 10125 | 205590_at | 0.5081 | 0.1369 | |
| GSE53622 | RASGRP1 | 10125 | 58702 | -0.6053 | 0.0000 | |
| GSE53624 | RASGRP1 | 10125 | 58702 | -1.1471 | 0.0000 | |
| GSE63941 | RASGRP1 | 10125 | 205590_at | 0.7808 | 0.4394 | |
| GSE77861 | RASGRP1 | 10125 | 205590_at | -0.4308 | 0.4038 | |
| GSE97050 | RASGRP1 | 10125 | A_23_P124642 | 0.3182 | 0.3506 | |
| SRP007169 | RASGRP1 | 10125 | RNAseq | -3.0521 | 0.0000 | |
| SRP008496 | RASGRP1 | 10125 | RNAseq | -2.6050 | 0.0000 | |
| SRP064894 | RASGRP1 | 10125 | RNAseq | -1.3803 | 0.0001 | |
| SRP133303 | RASGRP1 | 10125 | RNAseq | -0.5813 | 0.0116 | |
| SRP159526 | RASGRP1 | 10125 | RNAseq | -0.4194 | 0.4726 | |
| SRP193095 | RASGRP1 | 10125 | RNAseq | -0.5293 | 0.0027 | |
| SRP219564 | RASGRP1 | 10125 | RNAseq | -1.7394 | 0.0420 | |
| TCGA | RASGRP1 | 10125 | RNAseq | 0.3002 | 0.1034 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by RASGRP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RASGRP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RASGRP1 | 10125 | 2 | 7 | 21 | |
| GSE20123 | RASGRP1 | 10125 | 2 | 7 | 21 | |
| GSE43470 | RASGRP1 | 10125 | 4 | 5 | 34 | |
| GSE46452 | RASGRP1 | 10125 | 3 | 7 | 49 | |
| GSE47630 | RASGRP1 | 10125 | 8 | 11 | 21 | |
| GSE54993 | RASGRP1 | 10125 | 4 | 6 | 60 | |
| GSE54994 | RASGRP1 | 10125 | 5 | 7 | 41 | |
| GSE60625 | RASGRP1 | 10125 | 4 | 0 | 7 | |
| GSE74703 | RASGRP1 | 10125 | 4 | 4 | 28 | |
| GSE74704 | RASGRP1 | 10125 | 1 | 5 | 14 | |
| TCGA | RASGRP1 | 10125 | 11 | 18 | 67 |
Total number of gains: 48; Total number of losses: 77; Total Number of normals: 363.
Somatic mutations of RASGRP1:
Generating mutation plots.
Highly correlated genes for RASGRP1:
Showing top 20/784 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RASGRP1 | TMEM167A | 0.792673 | 3 | 0 | 3 |
| RASGRP1 | SLC31A1 | 0.731032 | 3 | 0 | 3 |
| RASGRP1 | AIMP1 | 0.7083 | 3 | 0 | 3 |
| RASGRP1 | MRRF | 0.694696 | 3 | 0 | 3 |
| RASGRP1 | MLKL | 0.687153 | 4 | 0 | 3 |
| RASGRP1 | PGM3 | 0.683618 | 4 | 0 | 3 |
| RASGRP1 | OSTC | 0.682696 | 4 | 0 | 4 |
| RASGRP1 | RUFY3 | 0.68135 | 5 | 0 | 5 |
| RASGRP1 | TMEM126A | 0.678447 | 3 | 0 | 3 |
| RASGRP1 | FYTTD1 | 0.676179 | 3 | 0 | 3 |
| RASGRP1 | BNIP3 | 0.672404 | 3 | 0 | 3 |
| RASGRP1 | CHCHD1 | 0.671165 | 4 | 0 | 4 |
| RASGRP1 | SLC38A9 | 0.670424 | 3 | 0 | 3 |
| RASGRP1 | ALKBH8 | 0.670368 | 3 | 0 | 3 |
| RASGRP1 | PRPF38A | 0.665976 | 3 | 0 | 3 |
| RASGRP1 | AP2S1 | 0.665961 | 3 | 0 | 3 |
| RASGRP1 | MFAP3 | 0.665878 | 5 | 0 | 3 |
| RASGRP1 | PNP | 0.663694 | 4 | 0 | 3 |
| RASGRP1 | TTC39B | 0.663653 | 4 | 0 | 3 |
| RASGRP1 | PPP4R2 | 0.663653 | 5 | 0 | 5 |
For details and further investigation, click here
