| Full name: matrix metallopeptidase 7 | Alias Symbol: PUMP-1 | ||
| Type: protein-coding gene | Cytoband: 11q22.2 | ||
| Entrez ID: 4316 | HGNC ID: HGNC:7174 | Ensembl Gene: ENSG00000137673 | OMIM ID: 178990 |
| Drug and gene relationship at DGIdb | |||
MMP7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of MMP7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP7 | 4316 | 204259_at | -0.1594 | 0.9676 | |
| GSE20347 | MMP7 | 4316 | 204259_at | 0.8803 | 0.0280 | |
| GSE23400 | MMP7 | 4316 | 204259_at | 0.4641 | 0.0301 | |
| GSE26886 | MMP7 | 4316 | 204259_at | 3.0061 | 0.0044 | |
| GSE29001 | MMP7 | 4316 | 204259_at | 2.1225 | 0.0004 | |
| GSE38129 | MMP7 | 4316 | 204259_at | 1.5132 | 0.0000 | |
| GSE45670 | MMP7 | 4316 | 204259_at | -0.0482 | 0.9563 | |
| GSE53622 | MMP7 | 4316 | 57475 | 2.0106 | 0.0000 | |
| GSE53624 | MMP7 | 4316 | 57475 | 0.6956 | 0.0342 | |
| GSE63941 | MMP7 | 4316 | 204259_at | 1.6473 | 0.3091 | |
| GSE77861 | MMP7 | 4316 | 204259_at | 0.3689 | 0.3814 | |
| GSE97050 | MMP7 | 4316 | A_23_P52761 | 1.7601 | 0.2850 | |
| SRP007169 | MMP7 | 4316 | RNAseq | 10.3551 | 0.0001 | |
| SRP008496 | MMP7 | 4316 | RNAseq | 8.8179 | 0.0000 | |
| SRP064894 | MMP7 | 4316 | RNAseq | 1.4915 | 0.0325 | |
| SRP133303 | MMP7 | 4316 | RNAseq | 0.9744 | 0.1319 | |
| SRP159526 | MMP7 | 4316 | RNAseq | 0.1163 | 0.9419 | |
| SRP219564 | MMP7 | 4316 | RNAseq | 2.2729 | 0.1067 | |
| TCGA | MMP7 | 4316 | RNAseq | 1.0599 | 0.0028 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by MMP7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP7 | 4316 | 5 | 8 | 17 | |
| GSE20123 | MMP7 | 4316 | 5 | 8 | 17 | |
| GSE43470 | MMP7 | 4316 | 6 | 5 | 32 | |
| GSE46452 | MMP7 | 4316 | 5 | 24 | 30 | |
| GSE47630 | MMP7 | 4316 | 2 | 19 | 19 | |
| GSE54993 | MMP7 | 4316 | 9 | 2 | 59 | |
| GSE54994 | MMP7 | 4316 | 6 | 18 | 29 | |
| GSE60625 | MMP7 | 4316 | 0 | 3 | 8 | |
| GSE74703 | MMP7 | 4316 | 4 | 4 | 28 | |
| GSE74704 | MMP7 | 4316 | 5 | 4 | 11 | |
| TCGA | MMP7 | 4316 | 10 | 44 | 42 |
Total number of gains: 57; Total number of losses: 139; Total Number of normals: 292.
Somatic mutations of MMP7:
Generating mutation plots.
Highly correlated genes for MMP7:
Showing top 20/206 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP7 | RUNX3 | 0.687695 | 4 | 0 | 3 |
| MMP7 | GSTA3 | 0.666937 | 3 | 0 | 3 |
| MMP7 | IKZF3 | 0.657773 | 3 | 0 | 3 |
| MMP7 | PDPN | 0.652954 | 3 | 0 | 3 |
| MMP7 | STC1 | 0.646023 | 4 | 0 | 4 |
| MMP7 | NRARP | 0.64068 | 3 | 0 | 3 |
| MMP7 | SAA2 | 0.639868 | 3 | 0 | 3 |
| MMP7 | CMPK2 | 0.638596 | 3 | 0 | 3 |
| MMP7 | PTPRK | 0.633447 | 3 | 0 | 3 |
| MMP7 | DPY19L4 | 0.63259 | 5 | 0 | 4 |
| MMP7 | ETV6 | 0.630935 | 4 | 0 | 4 |
| MMP7 | DMXL2 | 0.62796 | 6 | 0 | 5 |
| MMP7 | USP11 | 0.621371 | 3 | 0 | 3 |
| MMP7 | RCN1 | 0.6157 | 5 | 0 | 4 |
| MMP7 | OLFM4 | 0.609147 | 4 | 0 | 4 |
| MMP7 | TMEM132A | 0.607714 | 4 | 0 | 3 |
| MMP7 | FAM49B | 0.605325 | 5 | 0 | 3 |
| MMP7 | ICAM1 | 0.598464 | 4 | 0 | 4 |
| MMP7 | ADA | 0.598079 | 3 | 0 | 3 |
| MMP7 | NSMCE2 | 0.595895 | 3 | 0 | 3 |
For details and further investigation, click here
