| Full name: matrix metallopeptidase 8 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q22.2 | ||
| Entrez ID: 4317 | HGNC ID: HGNC:7175 | Ensembl Gene: ENSG00000118113 | OMIM ID: 120355 |
| Drug and gene relationship at DGIdb | |||
Expression of MMP8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP8 | 4317 | 207329_at | 0.0370 | 0.9020 | |
| GSE20347 | MMP8 | 4317 | 207329_at | 0.0758 | 0.3529 | |
| GSE23400 | MMP8 | 4317 | 207329_at | -0.0186 | 0.5570 | |
| GSE26886 | MMP8 | 4317 | 207329_at | 0.0091 | 0.9158 | |
| GSE29001 | MMP8 | 4317 | 207329_at | -0.1983 | 0.2091 | |
| GSE38129 | MMP8 | 4317 | 207329_at | -0.0513 | 0.5676 | |
| GSE45670 | MMP8 | 4317 | 207329_at | 0.0472 | 0.6023 | |
| GSE53622 | MMP8 | 4317 | 49057 | 1.5335 | 0.0000 | |
| GSE53624 | MMP8 | 4317 | 49057 | 1.1889 | 0.0000 | |
| GSE63941 | MMP8 | 4317 | 207329_at | 0.0537 | 0.7400 | |
| GSE77861 | MMP8 | 4317 | 207329_at | 0.0549 | 0.6062 | |
| TCGA | MMP8 | 4317 | RNAseq | 3.1822 | 0.0001 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by MMP8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP8 | 4317 | 5 | 8 | 17 | |
| GSE20123 | MMP8 | 4317 | 5 | 8 | 17 | |
| GSE43470 | MMP8 | 4317 | 5 | 5 | 33 | |
| GSE46452 | MMP8 | 4317 | 5 | 24 | 30 | |
| GSE47630 | MMP8 | 4317 | 2 | 19 | 19 | |
| GSE54993 | MMP8 | 4317 | 9 | 2 | 59 | |
| GSE54994 | MMP8 | 4317 | 6 | 18 | 29 | |
| GSE60625 | MMP8 | 4317 | 0 | 3 | 8 | |
| GSE74703 | MMP8 | 4317 | 3 | 4 | 29 | |
| GSE74704 | MMP8 | 4317 | 5 | 4 | 11 | |
| TCGA | MMP8 | 4317 | 10 | 44 | 42 |
Total number of gains: 55; Total number of losses: 139; Total Number of normals: 294.
Somatic mutations of MMP8:
Generating mutation plots.
Highly correlated genes for MMP8:
Showing top 20/133 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP8 | C6orf15 | 0.768859 | 3 | 0 | 3 |
| MMP8 | POU1F1 | 0.709013 | 3 | 0 | 3 |
| MMP8 | AMN | 0.701452 | 3 | 0 | 3 |
| MMP8 | CETN1 | 0.700008 | 3 | 0 | 3 |
| MMP8 | CHRM2 | 0.697982 | 3 | 0 | 3 |
| MMP8 | CHST5 | 0.666234 | 4 | 0 | 4 |
| MMP8 | ZIC3 | 0.665412 | 3 | 0 | 3 |
| MMP8 | IL13 | 0.664822 | 3 | 0 | 3 |
| MMP8 | PDE1B | 0.662341 | 3 | 0 | 3 |
| MMP8 | PLEK | 0.660623 | 3 | 0 | 3 |
| MMP8 | BCAN | 0.656789 | 3 | 0 | 3 |
| MMP8 | MMP25 | 0.655062 | 3 | 0 | 3 |
| MMP8 | TCL6 | 0.651356 | 3 | 0 | 3 |
| MMP8 | HPX | 0.648834 | 3 | 0 | 3 |
| MMP8 | SIGLEC5 | 0.64564 | 4 | 0 | 4 |
| MMP8 | GLP1R | 0.645614 | 3 | 0 | 3 |
| MMP8 | CXCR5 | 0.644722 | 3 | 0 | 3 |
| MMP8 | CAV3 | 0.642491 | 3 | 0 | 3 |
| MMP8 | PNPLA2 | 0.640382 | 3 | 0 | 3 |
| MMP8 | BLK | 0.639978 | 3 | 0 | 3 |
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