| Full name: MYB proto-oncogene, transcription factor | Alias Symbol: c-myb | ||
| Type: protein-coding gene | Cytoband: 6q23.3 | ||
| Entrez ID: 4602 | HGNC ID: HGNC:7545 | Ensembl Gene: ENSG00000118513 | OMIM ID: 189990 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
MYB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway |
Expression of MYB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYB | 4602 | 204798_at | 0.1018 | 0.9518 | |
| GSE20347 | MYB | 4602 | 204798_at | 0.1248 | 0.8246 | |
| GSE23400 | MYB | 4602 | 204798_at | -0.0192 | 0.8884 | |
| GSE26886 | MYB | 4602 | 204798_at | -0.7891 | 0.0757 | |
| GSE29001 | MYB | 4602 | 204798_at | -0.5505 | 0.4404 | |
| GSE38129 | MYB | 4602 | 204798_at | 0.5633 | 0.1726 | |
| GSE45670 | MYB | 4602 | 204798_at | -0.6751 | 0.0915 | |
| GSE53622 | MYB | 4602 | 4774 | -0.2407 | 0.3094 | |
| GSE53624 | MYB | 4602 | 29825 | -0.6463 | 0.0001 | |
| GSE63941 | MYB | 4602 | 204798_at | 1.6043 | 0.0527 | |
| GSE77861 | MYB | 4602 | 204798_at | -0.0636 | 0.8639 | |
| GSE97050 | MYB | 4602 | A_23_P31073 | 0.0829 | 0.8693 | |
| SRP007169 | MYB | 4602 | RNAseq | -0.9885 | 0.0187 | |
| SRP064894 | MYB | 4602 | RNAseq | -0.7581 | 0.0158 | |
| SRP133303 | MYB | 4602 | RNAseq | 0.0173 | 0.9678 | |
| SRP193095 | MYB | 4602 | RNAseq | -0.7469 | 0.0200 | |
| SRP219564 | MYB | 4602 | RNAseq | -0.5720 | 0.5319 | |
| TCGA | MYB | 4602 | RNAseq | 0.6108 | 0.0434 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MYB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYB | 4602 | 5 | 4 | 21 | |
| GSE20123 | MYB | 4602 | 5 | 3 | 22 | |
| GSE43470 | MYB | 4602 | 5 | 0 | 38 | |
| GSE46452 | MYB | 4602 | 3 | 10 | 46 | |
| GSE47630 | MYB | 4602 | 10 | 4 | 26 | |
| GSE54993 | MYB | 4602 | 3 | 2 | 65 | |
| GSE54994 | MYB | 4602 | 9 | 7 | 37 | |
| GSE60625 | MYB | 4602 | 0 | 1 | 10 | |
| GSE74703 | MYB | 4602 | 4 | 0 | 32 | |
| GSE74704 | MYB | 4602 | 2 | 1 | 17 | |
| TCGA | MYB | 4602 | 14 | 17 | 65 |
Total number of gains: 60; Total number of losses: 49; Total Number of normals: 379.
Somatic mutations of MYB:
Generating mutation plots.
Highly correlated genes for MYB:
Showing top 20/73 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYB | BROX | 0.65454 | 3 | 0 | 3 |
| MYB | MRPL51 | 0.644748 | 3 | 0 | 3 |
| MYB | KIAA1671 | 0.637694 | 4 | 0 | 3 |
| MYB | ZSCAN12 | 0.635752 | 4 | 0 | 4 |
| MYB | TMEM30B | 0.62947 | 3 | 0 | 3 |
| MYB | ZNF256 | 0.627296 | 3 | 0 | 3 |
| MYB | MUC4 | 0.625811 | 3 | 0 | 3 |
| MYB | CD3D | 0.621483 | 3 | 0 | 3 |
| MYB | HLA-DOB | 0.605123 | 3 | 0 | 3 |
| MYB | MBOAT1 | 0.59891 | 6 | 0 | 3 |
| MYB | ZNF254 | 0.598673 | 4 | 0 | 3 |
| MYB | TRIM7 | 0.598006 | 3 | 0 | 3 |
| MYB | ABRACL | 0.597255 | 3 | 0 | 3 |
| MYB | GRHL1 | 0.590153 | 4 | 0 | 3 |
| MYB | PPP4C | 0.58897 | 3 | 0 | 3 |
| MYB | TMBIM6 | 0.588594 | 4 | 0 | 3 |
| MYB | THAP9 | 0.587567 | 4 | 0 | 3 |
| MYB | COX5A | 0.58153 | 4 | 0 | 3 |
| MYB | CCDC77 | 0.576193 | 4 | 0 | 3 |
| MYB | SLC2A10 | 0.575903 | 5 | 0 | 4 |
For details and further investigation, click here
