| Full name: myosin light chain 12A | Alias Symbol: MLCB|MYL2B|MRLC3|MRCL3 | ||
| Type: protein-coding gene | Cytoband: 18p11.31 | ||
| Entrez ID: 10627 | HGNC ID: HGNC:16701 | Ensembl Gene: ENSG00000101608 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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MYL12A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04510 | Focal adhesion | |
| hsa04530 | Tight junction | |
| hsa04611 | Platelet activation | |
| hsa04670 | Leukocyte transendothelial migration | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of MYL12A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYL12A | 10627 | 201319_at | -0.0279 | 0.9687 | |
| GSE20347 | MYL12A | 10627 | 201319_at | -0.2883 | 0.0790 | |
| GSE23400 | MYL12A | 10627 | 201319_at | -0.1643 | 0.0131 | |
| GSE26886 | MYL12A | 10627 | 201319_at | -0.3598 | 0.0236 | |
| GSE29001 | MYL12A | 10627 | 201319_at | -0.1682 | 0.4683 | |
| GSE38129 | MYL12A | 10627 | 201319_at | -0.1615 | 0.2420 | |
| GSE45670 | MYL12A | 10627 | 201319_at | -0.0562 | 0.7587 | |
| GSE53622 | MYL12A | 10627 | 7675 | -0.3755 | 0.0000 | |
| GSE53624 | MYL12A | 10627 | 7675 | -0.2616 | 0.0003 | |
| GSE63941 | MYL12A | 10627 | 201319_at | -0.3640 | 0.5492 | |
| GSE77861 | MYL12A | 10627 | 201319_at | 0.1174 | 0.7964 | |
| GSE97050 | MYL12A | 10627 | A_23_P4572 | -0.1157 | 0.7335 | |
| SRP007169 | MYL12A | 10627 | RNAseq | -1.7576 | 0.0001 | |
| SRP008496 | MYL12A | 10627 | RNAseq | -1.6168 | 0.0000 | |
| SRP064894 | MYL12A | 10627 | RNAseq | 0.1999 | 0.5676 | |
| SRP133303 | MYL12A | 10627 | RNAseq | -0.1287 | 0.5571 | |
| SRP159526 | MYL12A | 10627 | RNAseq | -0.4763 | 0.0528 | |
| SRP193095 | MYL12A | 10627 | RNAseq | -0.5640 | 0.0028 | |
| SRP219564 | MYL12A | 10627 | RNAseq | -0.7682 | 0.0753 | |
| TCGA | MYL12A | 10627 | RNAseq | 0.0575 | 0.3475 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by MYL12A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYL12A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYL12A | 10627 | 8 | 1 | 21 | |
| GSE20123 | MYL12A | 10627 | 8 | 1 | 21 | |
| GSE43470 | MYL12A | 10627 | 4 | 5 | 34 | |
| GSE46452 | MYL12A | 10627 | 3 | 20 | 36 | |
| GSE47630 | MYL12A | 10627 | 8 | 17 | 15 | |
| GSE54993 | MYL12A | 10627 | 6 | 4 | 60 | |
| GSE54994 | MYL12A | 10627 | 11 | 8 | 34 | |
| GSE60625 | MYL12A | 10627 | 0 | 4 | 7 | |
| GSE74703 | MYL12A | 10627 | 3 | 3 | 30 | |
| GSE74704 | MYL12A | 10627 | 6 | 1 | 13 | |
| TCGA | MYL12A | 10627 | 35 | 19 | 42 |
Total number of gains: 92; Total number of losses: 83; Total Number of normals: 313.
Somatic mutations of MYL12A:
Generating mutation plots.
Highly correlated genes for MYL12A:
Showing top 20/71 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYL12A | MYL12B | 0.815629 | 12 | 0 | 11 |
| MYL12A | FAM210A | 0.690912 | 3 | 0 | 3 |
| MYL12A | MAP2K4 | 0.662874 | 3 | 0 | 3 |
| MYL12A | ADAM9 | 0.636419 | 3 | 0 | 3 |
| MYL12A | GTF3C6 | 0.629556 | 3 | 0 | 3 |
| MYL12A | REEP6 | 0.626208 | 3 | 0 | 3 |
| MYL12A | AP1S3 | 0.609753 | 4 | 0 | 3 |
| MYL12A | FER | 0.5981 | 4 | 0 | 3 |
| MYL12A | SERINC2 | 0.585497 | 4 | 0 | 3 |
| MYL12A | TRIB3 | 0.583948 | 3 | 0 | 3 |
| MYL12A | NDFIP2 | 0.580253 | 6 | 0 | 4 |
| MYL12A | FAM83A | 0.579971 | 6 | 0 | 3 |
| MYL12A | RNF144B | 0.576623 | 4 | 0 | 3 |
| MYL12A | PLIN3 | 0.574341 | 9 | 0 | 5 |
| MYL12A | NRAS | 0.572204 | 4 | 0 | 3 |
| MYL12A | C19orf33 | 0.567677 | 6 | 0 | 4 |
| MYL12A | PPP4R1 | 0.567462 | 12 | 0 | 8 |
| MYL12A | SESN2 | 0.562241 | 4 | 0 | 3 |
| MYL12A | CDK5R1 | 0.559179 | 5 | 0 | 3 |
| MYL12A | SPAG1 | 0.558923 | 7 | 0 | 5 |
For details and further investigation, click here
