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File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
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Multi-Omics Database of ESCC

 

FER

 

Full name: FER tyrosine kinase Alias Symbol: TYK3|PPP1R74
Type: protein-coding gene Cytoband: 5q21.3
Entrez ID: 2241 HGNC ID: HGNC:3655 Ensembl Gene: ENSG00000151422 OMIM ID: 176942
Drug and gene relationship at DGIdb

 

FER involved pathways:

KEGG pathway Description View
hsa04520Adherens junction

 

Expression of FER:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FER 2241 227579_at -0.2453 0.7462
GSE20347 FER 2241 206412_at -0.3565 0.0250
GSE23400 FER 2241 206412_at -0.2247 0.0000
GSE26886 FER 2241 206412_at -0.1942 0.3813
GSE29001 FER 2241 206412_at -0.5751 0.0658
GSE38129 FER 2241 206412_at -0.3656 0.0028
GSE45670 FER 2241 227579_at -0.2148 0.3236
GSE53622 FER 2241 36 -0.3675 0.0001
GSE53624 FER 2241 36 -0.1662 0.0173
GSE63941 FER 2241 227579_at -1.2346 0.0218
GSE77861 FER 2241 206412_at -0.2971 0.0494
GSE97050 FER 2241 A_23_P124570 -0.9029 0.1757
SRP007169 FER 2241 RNAseq -0.1398 0.7123
SRP008496 FER 2241 RNAseq 0.2413 0.3139
SRP064894 FER 2241 RNAseq 0.2105 0.4679
SRP133303 FER 2241 RNAseq 0.2081 0.0627
SRP159526 FER 2241 RNAseq 0.9720 0.0007
SRP193095 FER 2241 RNAseq 0.2026 0.0676
SRP219564 FER 2241 RNAseq 0.1067 0.7898
TCGA FER 2241 RNAseq -0.0769 0.5234

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by FER expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FER:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FER 2241 1 13 16
GSE20123 FER 2241 1 13 16
GSE43470 FER 2241 3 9 31
GSE46452 FER 2241 0 28 31
GSE47630 FER 2241 0 21 19
GSE54993 FER 2241 9 1 60
GSE54994 FER 2241 1 17 35
GSE60625 FER 2241 0 0 11
GSE74703 FER 2241 2 7 27
GSE74704 FER 2241 1 7 12
TCGA FER 2241 2 43 51

Total number of gains: 20; Total number of losses: 159; Total Number of normals: 309.  

 

Somatic mutations of FER:

 

Generating mutation plots.

 

Highly correlated genes for FER:

 

Showing top 20/115 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FERPLA2G4A0.671687303
FERRBKS0.668406303
FERMYL12B0.641537303
FERBDP10.635349303
FERCDK70.615111605
FERCLDN170.606583303
FERUSP320.60228403
FERMAN2A10.599111605
FERARL140.598973504
FERMYL12A0.5981403
FERSOWAHC0.593316503
FERNME60.587716605
FERCD820.581136503
FEREMC30.57916605
FERCWH430.579073705
FERIL6ST0.576986604
FERPRDM40.573808403
FERNABP10.573016504
FERHS3ST10.570784403
FERATP10D0.569632706

For details and further investigation, click here