MAP2K4

 

Full name: mitogen-activated protein kinase kinase 4 Alias Symbol: MEK4|JNKK1|PRKMK4|MKK4
Type: protein-coding gene Cytoband: 17p12
Entrez ID: 6416 HGNC ID: HGNC:6844 Ensembl Gene: ENSG00000065559 OMIM ID: 601335
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 37/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

MAP2K4 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04668TNF signaling pathway
hsa04912GnRH signaling pathway
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05142Chagas disease (American trypanosomiasis)
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection

 

Expression of MAP2K4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAP2K4 6416 203266_s_at -0.3556 0.5465
GSE20347 MAP2K4 6416 203266_s_at -0.7415 0.0001
GSE23400 MAP2K4 6416 203266_s_at -0.3788 0.0000
GSE26886 MAP2K4 6416 203266_s_at -0.8212 0.0001
GSE29001 MAP2K4 6416 203266_s_at -0.5658 0.0195
GSE38129 MAP2K4 6416 203266_s_at -0.4373 0.0077
GSE45670 MAP2K4 6416 203266_s_at -0.1376 0.2752
GSE53622 MAP2K4 6416 3319 -0.7689 0.0000
GSE53624 MAP2K4 6416 3319 -0.6577 0.0000
GSE63941 MAP2K4 6416 203266_s_at -0.2963 0.5331
GSE77861 MAP2K4 6416 203266_s_at -0.2212 0.2612
GSE97050 MAP2K4 6416 A_33_P3653330 0.1230 0.6291
SRP007169 MAP2K4 6416 RNAseq -1.3031 0.0061
SRP008496 MAP2K4 6416 RNAseq -1.0064 0.0000
SRP064894 MAP2K4 6416 RNAseq -0.4034 0.1333
SRP133303 MAP2K4 6416 RNAseq -0.4102 0.0045
SRP159526 MAP2K4 6416 RNAseq -0.8057 0.0078
SRP193095 MAP2K4 6416 RNAseq -0.7395 0.0000
SRP219564 MAP2K4 6416 RNAseq -0.6174 0.0664
TCGA MAP2K4 6416 RNAseq -0.0558 0.2464

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by MAP2K4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAP2K4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAP2K4 6416 3 4 23
GSE20123 MAP2K4 6416 3 5 22
GSE43470 MAP2K4 6416 2 5 36
GSE46452 MAP2K4 6416 34 1 24
GSE47630 MAP2K4 6416 7 1 32
GSE54993 MAP2K4 6416 3 2 65
GSE54994 MAP2K4 6416 6 6 41
GSE60625 MAP2K4 6416 4 0 7
GSE74703 MAP2K4 6416 2 4 30
GSE74704 MAP2K4 6416 2 2 16
TCGA MAP2K4 6416 18 21 57

Total number of gains: 84; Total number of losses: 51; Total Number of normals: 353.  

 

Somatic mutations of MAP2K4:

 

Generating mutation plots.

 

Highly correlated genes for MAP2K4:

 

Showing top 20/1206 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAP2K4RNFT10.7611303
MAP2K4NUAK20.754344303
MAP2K4NIPAL10.732154303
MAP2K4TAX1BP30.711437303
MAP2K4ZNF8230.708579505
MAP2K4MPZL30.698255706
MAP2K4ACOT120.697419303
MAP2K4KIF21A0.688968504
MAP2K4LTA4H0.687362303
MAP2K4SH3GL10.68573911010
MAP2K4TBC1D20.683817403
MAP2K4GBP60.681998404
MAP2K4ZDHHC120.681263303
MAP2K4SIAE0.681038504
MAP2K4CAPN140.679949504
MAP2K4ANKRD310.675692404
MAP2K4C7orf570.671374505
MAP2K4PLIN30.67101610010
MAP2K4FRMD4B0.6696641009
MAP2K4GSTZ10.669365403

For details and further investigation, click here