| Full name: NDUFA4 mitochondrial complex associated | Alias Symbol: MLRQ|CI-9k|COXFA4 | ||
| Type: protein-coding gene | Cytoband: 7p21.3 | ||
| Entrez ID: 4697 | HGNC ID: HGNC:7687 | Ensembl Gene: ENSG00000189043 | OMIM ID: 603833 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NDUFA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NDUFA4 | 4697 | 217773_s_at | -0.2456 | 0.3887 | |
| GSE20347 | NDUFA4 | 4697 | 217773_s_at | 0.1528 | 0.4674 | |
| GSE23400 | NDUFA4 | 4697 | 217773_s_at | 0.0743 | 0.3732 | |
| GSE26886 | NDUFA4 | 4697 | 217773_s_at | 0.1742 | 0.4400 | |
| GSE29001 | NDUFA4 | 4697 | 217773_s_at | -0.2593 | 0.4374 | |
| GSE38129 | NDUFA4 | 4697 | 217773_s_at | 0.0526 | 0.7108 | |
| GSE45670 | NDUFA4 | 4697 | 217773_s_at | 0.0274 | 0.7875 | |
| GSE53622 | NDUFA4 | 4697 | 54630 | 0.0288 | 0.7812 | |
| GSE53624 | NDUFA4 | 4697 | 54630 | 0.3522 | 0.0000 | |
| GSE63941 | NDUFA4 | 4697 | 217773_s_at | 0.2117 | 0.4124 | |
| GSE77861 | NDUFA4 | 4697 | 217773_s_at | 0.0336 | 0.9214 | |
| GSE97050 | NDUFA4 | 4697 | A_23_P145777 | 0.0620 | 0.8862 | |
| SRP007169 | NDUFA4 | 4697 | RNAseq | -0.6164 | 0.0402 | |
| SRP008496 | NDUFA4 | 4697 | RNAseq | -0.4404 | 0.0656 | |
| SRP064894 | NDUFA4 | 4697 | RNAseq | -0.0351 | 0.9135 | |
| SRP133303 | NDUFA4 | 4697 | RNAseq | 0.2577 | 0.0889 | |
| SRP159526 | NDUFA4 | 4697 | RNAseq | 0.5021 | 0.1221 | |
| SRP193095 | NDUFA4 | 4697 | RNAseq | -0.6276 | 0.0003 | |
| SRP219564 | NDUFA4 | 4697 | RNAseq | -0.3902 | 0.3345 | |
| TCGA | NDUFA4 | 4697 | RNAseq | -0.1300 | 0.0076 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NDUFA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NDUFA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NDUFA4 | 4697 | 14 | 2 | 14 | |
| GSE20123 | NDUFA4 | 4697 | 14 | 2 | 14 | |
| GSE43470 | NDUFA4 | 4697 | 5 | 0 | 38 | |
| GSE46452 | NDUFA4 | 4697 | 11 | 1 | 47 | |
| GSE47630 | NDUFA4 | 4697 | 9 | 1 | 30 | |
| GSE54993 | NDUFA4 | 4697 | 0 | 6 | 64 | |
| GSE54994 | NDUFA4 | 4697 | 22 | 1 | 30 | |
| GSE60625 | NDUFA4 | 4697 | 0 | 0 | 11 | |
| GSE74703 | NDUFA4 | 4697 | 5 | 0 | 31 | |
| GSE74704 | NDUFA4 | 4697 | 8 | 2 | 10 | |
| TCGA | NDUFA4 | 4697 | 55 | 6 | 35 |
Total number of gains: 143; Total number of losses: 21; Total Number of normals: 324.
Somatic mutations of NDUFA4:
Generating mutation plots.
Highly correlated genes for NDUFA4:
Showing top 20/221 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NDUFA4 | NCOA4 | 0.737522 | 3 | 0 | 3 |
| NDUFA4 | OST4 | 0.698114 | 3 | 0 | 3 |
| NDUFA4 | MRPL10 | 0.685181 | 3 | 0 | 3 |
| NDUFA4 | COG5 | 0.680433 | 3 | 0 | 3 |
| NDUFA4 | EIF4G2 | 0.678412 | 3 | 0 | 3 |
| NDUFA4 | MTFMT | 0.676154 | 4 | 0 | 4 |
| NDUFA4 | ZNHIT1 | 0.676132 | 4 | 0 | 4 |
| NDUFA4 | ZDHHC3 | 0.66986 | 3 | 0 | 3 |
| NDUFA4 | SPCS1 | 0.669134 | 4 | 0 | 3 |
| NDUFA4 | SARNP | 0.650978 | 3 | 0 | 3 |
| NDUFA4 | NSMCE1 | 0.64363 | 4 | 0 | 4 |
| NDUFA4 | VPS35 | 0.640221 | 3 | 0 | 3 |
| NDUFA4 | EGFR | 0.637907 | 3 | 0 | 3 |
| NDUFA4 | VBP1 | 0.637851 | 6 | 0 | 6 |
| NDUFA4 | VPS29 | 0.635373 | 4 | 0 | 3 |
| NDUFA4 | TOMM7 | 0.633893 | 3 | 0 | 3 |
| NDUFA4 | UBE4A | 0.632299 | 4 | 0 | 3 |
| NDUFA4 | ZNF510 | 0.630011 | 3 | 0 | 3 |
| NDUFA4 | MRPS27 | 0.629724 | 3 | 0 | 3 |
| NDUFA4 | SOCS5 | 0.629684 | 6 | 0 | 5 |
For details and further investigation, click here
