| Full name: VPS35 retromer complex component | Alias Symbol: FLJ10752|MEM3|PARK17 | ||
| Type: protein-coding gene | Cytoband: 16q11.2 | ||
| Entrez ID: 55737 | HGNC ID: HGNC:13487 | Ensembl Gene: ENSG00000069329 | OMIM ID: 601501 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of VPS35:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS35 | 55737 | 217727_x_at | 0.1791 | 0.5742 | |
| GSE20347 | VPS35 | 55737 | 217727_x_at | 0.0703 | 0.5718 | |
| GSE23400 | VPS35 | 55737 | 217727_x_at | 0.0618 | 0.3129 | |
| GSE26886 | VPS35 | 55737 | 217727_x_at | 0.0615 | 0.7206 | |
| GSE29001 | VPS35 | 55737 | 217727_x_at | -0.2488 | 0.1635 | |
| GSE38129 | VPS35 | 55737 | 217727_x_at | 0.1531 | 0.1476 | |
| GSE45670 | VPS35 | 55737 | 217727_x_at | -0.0347 | 0.6987 | |
| GSE53622 | VPS35 | 55737 | 23624 | -0.0417 | 0.4495 | |
| GSE53624 | VPS35 | 55737 | 23624 | -0.1551 | 0.0008 | |
| GSE63941 | VPS35 | 55737 | 217727_x_at | 0.0952 | 0.7687 | |
| GSE77861 | VPS35 | 55737 | 217727_x_at | 0.2101 | 0.1874 | |
| GSE97050 | VPS35 | 55737 | A_32_P3556 | 0.0670 | 0.7701 | |
| SRP007169 | VPS35 | 55737 | RNAseq | -0.9372 | 0.0031 | |
| SRP008496 | VPS35 | 55737 | RNAseq | -0.7845 | 0.0004 | |
| SRP064894 | VPS35 | 55737 | RNAseq | -0.5039 | 0.0004 | |
| SRP133303 | VPS35 | 55737 | RNAseq | 0.0990 | 0.5358 | |
| SRP159526 | VPS35 | 55737 | RNAseq | -0.3213 | 0.2475 | |
| SRP193095 | VPS35 | 55737 | RNAseq | -0.5438 | 0.0000 | |
| SRP219564 | VPS35 | 55737 | RNAseq | -0.4908 | 0.1478 | |
| TCGA | VPS35 | 55737 | RNAseq | 0.0252 | 0.5358 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by VPS35 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS35:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS35 | 55737 | 2 | 2 | 26 | |
| GSE20123 | VPS35 | 55737 | 2 | 2 | 26 | |
| GSE43470 | VPS35 | 55737 | 2 | 7 | 34 | |
| GSE46452 | VPS35 | 55737 | 38 | 1 | 20 | |
| GSE47630 | VPS35 | 55737 | 11 | 7 | 22 | |
| GSE54993 | VPS35 | 55737 | 2 | 5 | 63 | |
| GSE54994 | VPS35 | 55737 | 6 | 10 | 37 | |
| GSE60625 | VPS35 | 55737 | 4 | 0 | 7 | |
| GSE74703 | VPS35 | 55737 | 2 | 4 | 30 | |
| GSE74704 | VPS35 | 55737 | 2 | 2 | 16 | |
| TCGA | VPS35 | 55737 | 29 | 11 | 56 |
Total number of gains: 100; Total number of losses: 51; Total Number of normals: 337.
Somatic mutations of VPS35:
Generating mutation plots.
Highly correlated genes for VPS35:
Showing top 20/366 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS35 | PRRC1 | 0.767644 | 3 | 0 | 3 |
| VPS35 | NRBF2 | 0.761002 | 4 | 0 | 4 |
| VPS35 | C1QBP | 0.755235 | 3 | 0 | 3 |
| VPS35 | WDR54 | 0.747925 | 3 | 0 | 3 |
| VPS35 | SMU1 | 0.747436 | 3 | 0 | 3 |
| VPS35 | FBXO33 | 0.743986 | 3 | 0 | 3 |
| VPS35 | GSTO1 | 0.740274 | 3 | 0 | 3 |
| VPS35 | SERTAD2 | 0.733258 | 3 | 0 | 3 |
| VPS35 | YY1 | 0.731308 | 3 | 0 | 3 |
| VPS35 | NCF2 | 0.728056 | 3 | 0 | 3 |
| VPS35 | NUDT5 | 0.726341 | 3 | 0 | 3 |
| VPS35 | MYO5A | 0.72353 | 3 | 0 | 3 |
| VPS35 | AKR1B1 | 0.721959 | 3 | 0 | 3 |
| VPS35 | MNAT1 | 0.715997 | 3 | 0 | 3 |
| VPS35 | RIN2 | 0.715037 | 4 | 0 | 3 |
| VPS35 | HDAC3 | 0.697861 | 3 | 0 | 3 |
| VPS35 | DEK | 0.697567 | 3 | 0 | 3 |
| VPS35 | NOL7 | 0.697552 | 3 | 0 | 3 |
| VPS35 | KIF2A | 0.694562 | 4 | 0 | 3 |
| VPS35 | COPS5 | 0.694109 | 3 | 0 | 3 |
For details and further investigation, click here
