NFATC3

 

Full name: nuclear factor of activated T cells 3 Alias Symbol: NFAT4|NFATX
Type: protein-coding gene Cytoband: 16q22.1
Entrez ID: 4775 HGNC ID: HGNC:7777 Ensembl Gene: ENSG00000072736 OMIM ID: 602698
Drug and gene relationship at DGIdb

 

NFATC3 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04921Oxytocin signaling pathway
hsa05161Hepatitis B
hsa05166HTLV-I infection

 

Expression of NFATC3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NFATC3 4775 225141_at 0.3462 0.3919
GSE20347 NFATC3 4775 210555_s_at 0.6212 0.0026
GSE23400 NFATC3 4775 210555_s_at 0.4153 0.0000
GSE26886 NFATC3 4775 225141_at 0.3241 0.0151
GSE29001 NFATC3 4775 210555_s_at 0.7309 0.0867
GSE38129 NFATC3 4775 210555_s_at 0.4965 0.0095
GSE45670 NFATC3 4775 225141_at 0.3351 0.0022
GSE53622 NFATC3 4775 132114 0.3653 0.0000
GSE53624 NFATC3 4775 132114 0.3412 0.0000
GSE63941 NFATC3 4775 225141_at 0.5036 0.1522
GSE77861 NFATC3 4775 210555_s_at 0.5449 0.0267
GSE97050 NFATC3 4775 A_23_P77440 0.2433 0.3713
SRP007169 NFATC3 4775 RNAseq 0.1806 0.6089
SRP008496 NFATC3 4775 RNAseq 0.1288 0.5935
SRP064894 NFATC3 4775 RNAseq -0.1543 0.2341
SRP133303 NFATC3 4775 RNAseq 0.1064 0.3795
SRP159526 NFATC3 4775 RNAseq 0.3010 0.1951
SRP193095 NFATC3 4775 RNAseq -0.0140 0.8823
SRP219564 NFATC3 4775 RNAseq -0.3362 0.1948
TCGA NFATC3 4775 RNAseq 0.1234 0.0145

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by NFATC3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NFATC3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NFATC3 4775 9 2 19
GSE20123 NFATC3 4775 9 2 19
GSE43470 NFATC3 4775 1 9 33
GSE46452 NFATC3 4775 38 1 20
GSE47630 NFATC3 4775 11 8 21
GSE54993 NFATC3 4775 2 4 64
GSE54994 NFATC3 4775 8 10 35
GSE60625 NFATC3 4775 4 0 7
GSE74703 NFATC3 4775 1 6 29
GSE74704 NFATC3 4775 5 1 14
TCGA NFATC3 4775 31 12 53

Total number of gains: 119; Total number of losses: 55; Total Number of normals: 314.  

 

Somatic mutations of NFATC3:

 

Generating mutation plots.

 

Highly correlated genes for NFATC3:

 

Showing top 20/715 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NFATC3HNRNPM0.740035808
NFATC3CNOT10.719688303
NFATC3ZSCAN210.713484303
NFATC3TMEM2080.693912808
NFATC3USP30.686306303
NFATC3MSL30.685666303
NFATC3DUS3L0.68539303
NFATC3ERP290.678032504
NFATC3RAB130.670537303
NFATC3LRRC140.670007303
NFATC3FAM118B0.669277403
NFATC3LRRC580.667706404
NFATC3NIT20.666862504
NFATC3PARN0.664219807
NFATC3SDHAF20.660127605
NFATC3CLEC12A0.658719403
NFATC3PRMT10.65731007
NFATC3SMARCE10.652571303
NFATC3POLDIP30.650887303
NFATC3VKORC10.649158907

For details and further investigation, click here