ADAM17

 

Full name: ADAM metallopeptidase domain 17 Alias Symbol: cSVP|CD156B
Type: protein-coding gene Cytoband: 2p25.1
Entrez ID: 6868 HGNC ID: HGNC:195 Ensembl Gene: ENSG00000151694 OMIM ID: 603639
Drug and gene relationship at DGIdb

 

ADAM17 involved pathways:

KEGG pathway Description View
hsa04330Notch signaling pathway
hsa05120Epithelial cell signaling in Helicobacter pylori infection

 

Expression of ADAM17:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADAM17 6868 213532_at 0.8601 0.1193
GSE20347 ADAM17 6868 213532_at 0.5561 0.0014
GSE23400 ADAM17 6868 213532_at 0.6815 0.0000
GSE26886 ADAM17 6868 213532_at 1.1822 0.0000
GSE29001 ADAM17 6868 205745_x_at 0.6949 0.0098
GSE38129 ADAM17 6868 213532_at 0.8875 0.0000
GSE45670 ADAM17 6868 213532_at 0.6691 0.0010
GSE53622 ADAM17 6868 44910 1.0723 0.0000
GSE53624 ADAM17 6868 44910 0.7456 0.0000
GSE63941 ADAM17 6868 213532_at -0.2034 0.7005
GSE77861 ADAM17 6868 213532_at 0.6397 0.0081
GSE97050 ADAM17 6868 A_23_P143120 1.1078 0.0880
SRP007169 ADAM17 6868 RNAseq 0.9701 0.0065
SRP008496 ADAM17 6868 RNAseq 1.1015 0.0015
SRP064894 ADAM17 6868 RNAseq 0.5168 0.1522
SRP133303 ADAM17 6868 RNAseq 0.7020 0.0000
SRP159526 ADAM17 6868 RNAseq 1.2256 0.0035
SRP193095 ADAM17 6868 RNAseq 0.7823 0.0000
SRP219564 ADAM17 6868 RNAseq 0.5001 0.3642
TCGA ADAM17 6868 RNAseq 0.4383 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by ADAM17 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ADAM17:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADAM17 6868 11 2 17
GSE20123 ADAM17 6868 11 2 17
GSE43470 ADAM17 6868 2 1 40
GSE46452 ADAM17 6868 3 4 52
GSE47630 ADAM17 6868 7 0 33
GSE54993 ADAM17 6868 0 7 63
GSE54994 ADAM17 6868 11 1 41
GSE60625 ADAM17 6868 0 3 8
GSE74703 ADAM17 6868 2 0 34
GSE74704 ADAM17 6868 9 1 10
TCGA ADAM17 6868 34 5 57

Total number of gains: 90; Total number of losses: 26; Total Number of normals: 372.  

 

Somatic mutations of ADAM17:

 

Generating mutation plots.

 

Highly correlated genes for ADAM17:

 

Showing top 20/1500 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADAM17PSME40.79369911011
ADAM17EME10.769989504
ADAM17NFKB20.768312303
ADAM17FAM89A0.767717303
ADAM17RNF2130.764619303
ADAM17COMMD20.761214404
ADAM17SPRR2G0.760276303
ADAM17PDE8A0.734146303
ADAM17BLACAT10.731719404
ADAM17MMS22L0.730904303
ADAM17CPSF30.728994807
ADAM17HAS30.728757505
ADAM17XPR10.726581706
ADAM17CEP550.7252591009
ADAM17CAD0.72140811011
ADAM17ISG20L20.716651009
ADAM17MPLKIP0.71655606
ADAM17LRRC8A0.712344303
ADAM17NEK80.712003303
ADAM17RFWD30.71129710010

For details and further investigation, click here