| Full name: notchless homolog 1 | Alias Symbol: FLJ10458 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 54475 | HGNC ID: HGNC:19889 | Ensembl Gene: ENSG00000073536 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NLE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NLE1 | 54475 | 203867_s_at | 0.8860 | 0.0632 | |
| GSE20347 | NLE1 | 54475 | 203867_s_at | 0.4482 | 0.0096 | |
| GSE23400 | NLE1 | 54475 | 203867_s_at | 0.2344 | 0.0003 | |
| GSE26886 | NLE1 | 54475 | 203867_s_at | 0.4639 | 0.0127 | |
| GSE29001 | NLE1 | 54475 | 203867_s_at | 0.2861 | 0.1729 | |
| GSE38129 | NLE1 | 54475 | 203867_s_at | 0.5062 | 0.0005 | |
| GSE45670 | NLE1 | 54475 | 203867_s_at | 0.2945 | 0.0424 | |
| GSE53622 | NLE1 | 54475 | 30377 | 0.7096 | 0.0000 | |
| GSE53624 | NLE1 | 54475 | 30377 | 0.5317 | 0.0000 | |
| GSE63941 | NLE1 | 54475 | 203867_s_at | 0.5917 | 0.2941 | |
| GSE77861 | NLE1 | 54475 | 203867_s_at | 0.1072 | 0.5269 | |
| GSE97050 | NLE1 | 54475 | A_33_P3361513 | 0.1276 | 0.4966 | |
| SRP007169 | NLE1 | 54475 | RNAseq | 0.5737 | 0.1290 | |
| SRP008496 | NLE1 | 54475 | RNAseq | 0.3610 | 0.2853 | |
| SRP064894 | NLE1 | 54475 | RNAseq | 0.1845 | 0.4328 | |
| SRP133303 | NLE1 | 54475 | RNAseq | 0.1981 | 0.1217 | |
| SRP159526 | NLE1 | 54475 | RNAseq | 0.2020 | 0.5052 | |
| SRP193095 | NLE1 | 54475 | RNAseq | 0.2245 | 0.0658 | |
| SRP219564 | NLE1 | 54475 | RNAseq | 0.1427 | 0.6541 | |
| TCGA | NLE1 | 54475 | RNAseq | 0.1473 | 0.0318 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NLE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NLE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NLE1 | 54475 | 5 | 1 | 24 | |
| GSE20123 | NLE1 | 54475 | 5 | 1 | 24 | |
| GSE43470 | NLE1 | 54475 | 1 | 2 | 40 | |
| GSE46452 | NLE1 | 54475 | 34 | 0 | 25 | |
| GSE47630 | NLE1 | 54475 | 7 | 1 | 32 | |
| GSE54993 | NLE1 | 54475 | 3 | 3 | 64 | |
| GSE54994 | NLE1 | 54475 | 8 | 6 | 39 | |
| GSE60625 | NLE1 | 54475 | 4 | 0 | 7 | |
| GSE74703 | NLE1 | 54475 | 1 | 1 | 34 | |
| GSE74704 | NLE1 | 54475 | 3 | 1 | 16 | |
| TCGA | NLE1 | 54475 | 20 | 9 | 67 |
Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.
Somatic mutations of NLE1:
Generating mutation plots.
Highly correlated genes for NLE1:
Showing top 20/695 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NLE1 | PHTF1 | 0.772153 | 3 | 0 | 3 |
| NLE1 | MNDA | 0.76185 | 3 | 0 | 3 |
| NLE1 | RAPGEF1 | 0.745283 | 3 | 0 | 3 |
| NLE1 | PPP1R18 | 0.689004 | 4 | 0 | 3 |
| NLE1 | ORAI1 | 0.6872 | 3 | 0 | 3 |
| NLE1 | MAN2B1 | 0.682717 | 3 | 0 | 3 |
| NLE1 | ITGB2 | 0.671415 | 3 | 0 | 3 |
| NLE1 | TRPV2 | 0.665987 | 3 | 0 | 3 |
| NLE1 | CD180 | 0.662319 | 3 | 0 | 3 |
| NLE1 | WDR62 | 0.660592 | 3 | 0 | 3 |
| NLE1 | DOCK11 | 0.657923 | 3 | 0 | 3 |
| NLE1 | FHL2 | 0.651543 | 3 | 0 | 3 |
| NLE1 | SERPINA1 | 0.648284 | 4 | 0 | 3 |
| NLE1 | BCL2A1 | 0.646072 | 4 | 0 | 3 |
| NLE1 | TSHZ3 | 0.645922 | 3 | 0 | 3 |
| NLE1 | KCTD13 | 0.643459 | 3 | 0 | 3 |
| NLE1 | FCER1G | 0.640477 | 5 | 0 | 4 |
| NLE1 | SRRD | 0.64033 | 5 | 0 | 4 |
| NLE1 | HEXA | 0.632865 | 5 | 0 | 4 |
| NLE1 | LINC01029 | 0.629308 | 3 | 0 | 3 |
For details and further investigation, click here
