NOTCH1

 

Full name: notch receptor 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 9q34.3
Entrez ID: 4851 HGNC ID: HGNC:7881 Ensembl Gene: ENSG00000148400 OMIM ID: 190198
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

NOTCH1 involved pathways:

KEGG pathway Description View
hsa04330Notch signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa05020Prion diseases

 

Expression of NOTCH1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NOTCH1 4851 218902_at 0.6885 0.2710
GSE20347 NOTCH1 4851 218902_at 0.1258 0.5015
GSE23400 NOTCH1 4851 218902_at 0.3018 0.0005
GSE26886 NOTCH1 4851 218902_at 0.8206 0.0105
GSE29001 NOTCH1 4851 218902_at 0.1662 0.6347
GSE38129 NOTCH1 4851 218902_at 0.0765 0.6385
GSE45670 NOTCH1 4851 218902_at 0.1271 0.5750
GSE53622 NOTCH1 4851 78996 0.1421 0.0377
GSE53624 NOTCH1 4851 78996 -0.1472 0.0947
GSE63941 NOTCH1 4851 218902_at 1.3604 0.0021
GSE77861 NOTCH1 4851 218902_at 0.0681 0.5895
GSE97050 NOTCH1 4851 A_33_P3370424 0.2052 0.3026
SRP007169 NOTCH1 4851 RNAseq 1.2700 0.0054
SRP008496 NOTCH1 4851 RNAseq 0.7979 0.0401
SRP064894 NOTCH1 4851 RNAseq -0.0671 0.8071
SRP133303 NOTCH1 4851 RNAseq -0.0556 0.8182
SRP159526 NOTCH1 4851 RNAseq 1.0147 0.0478
SRP193095 NOTCH1 4851 RNAseq 0.4208 0.0345
SRP219564 NOTCH1 4851 RNAseq -0.2958 0.3824
TCGA NOTCH1 4851 RNAseq 0.2993 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by NOTCH1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NOTCH1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NOTCH1 4851 4 7 19
GSE20123 NOTCH1 4851 4 7 19
GSE43470 NOTCH1 4851 3 7 33
GSE46452 NOTCH1 4851 6 13 40
GSE47630 NOTCH1 4851 6 15 19
GSE54993 NOTCH1 4851 3 3 64
GSE54994 NOTCH1 4851 13 7 33
GSE60625 NOTCH1 4851 0 0 11
GSE74703 NOTCH1 4851 3 5 28
GSE74704 NOTCH1 4851 2 5 13
TCGA NOTCH1 4851 29 24 43

Total number of gains: 73; Total number of losses: 93; Total Number of normals: 322.  

 

Somatic mutations of NOTCH1:

 

Generating mutation plots.

 

Highly correlated genes for NOTCH1:

 

Showing top 20/223 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NOTCH1SMARCD10.728552303
NOTCH1ZNFX10.725969303
NOTCH1RNF1260.724337303
NOTCH1PRDM150.720768303
NOTCH1FOXP40.685514303
NOTCH1PRPF4B0.685232303
NOTCH1LIPE0.682159303
NOTCH1CHD40.68103303
NOTCH1PPRC10.677711303
NOTCH1NAA500.67647404
NOTCH1TAP10.6733303
NOTCH1GSK3B0.671891303
NOTCH1ZNF6680.668798403
NOTCH1RNF20.66867303
NOTCH1APOBEC3B0.667001303
NOTCH1KRI10.664107303
NOTCH1NRARP0.663408303
NOTCH1SLC38A70.661751403
NOTCH1LAMP30.660374303
NOTCH1CNOT20.659057303

For details and further investigation, click here