| Full name: solute carrier family 25 member 46 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q22.1 | ||
| Entrez ID: 91137 | HGNC ID: HGNC:25198 | Ensembl Gene: ENSG00000164209 | OMIM ID: 610826 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SLC25A46:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC25A46 | 91137 | 212833_at | -0.5060 | 0.2772 | |
| GSE20347 | SLC25A46 | 91137 | 212833_at | -0.5365 | 0.0011 | |
| GSE23400 | SLC25A46 | 91137 | 212833_at | 0.0337 | 0.7419 | |
| GSE26886 | SLC25A46 | 91137 | 212833_at | 0.1521 | 0.4950 | |
| GSE29001 | SLC25A46 | 91137 | 212833_at | -0.3807 | 0.2079 | |
| GSE38129 | SLC25A46 | 91137 | 212833_at | -0.3693 | 0.0107 | |
| GSE45670 | SLC25A46 | 91137 | 212833_at | -0.1028 | 0.5908 | |
| GSE53622 | SLC25A46 | 91137 | 151835 | -0.3917 | 0.0000 | |
| GSE53624 | SLC25A46 | 91137 | 151835 | -0.3694 | 0.0028 | |
| GSE63941 | SLC25A46 | 91137 | 212833_at | -0.4671 | 0.2467 | |
| GSE77861 | SLC25A46 | 91137 | 212833_at | -0.7432 | 0.0504 | |
| GSE97050 | SLC25A46 | 91137 | A_33_P3347392 | -0.1456 | 0.6541 | |
| SRP007169 | SLC25A46 | 91137 | RNAseq | -1.1896 | 0.0006 | |
| SRP008496 | SLC25A46 | 91137 | RNAseq | -0.8583 | 0.0000 | |
| SRP064894 | SLC25A46 | 91137 | RNAseq | -0.2446 | 0.1365 | |
| SRP133303 | SLC25A46 | 91137 | RNAseq | 0.0768 | 0.6863 | |
| SRP159526 | SLC25A46 | 91137 | RNAseq | -0.8092 | 0.0281 | |
| SRP193095 | SLC25A46 | 91137 | RNAseq | -0.8744 | 0.0000 | |
| SRP219564 | SLC25A46 | 91137 | RNAseq | -0.5494 | 0.1442 | |
| TCGA | SLC25A46 | 91137 | RNAseq | -0.1340 | 0.0104 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SLC25A46 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC25A46:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC25A46 | 91137 | 1 | 13 | 16 | |
| GSE20123 | SLC25A46 | 91137 | 1 | 13 | 16 | |
| GSE43470 | SLC25A46 | 91137 | 3 | 8 | 32 | |
| GSE46452 | SLC25A46 | 91137 | 0 | 28 | 31 | |
| GSE47630 | SLC25A46 | 91137 | 0 | 21 | 19 | |
| GSE54993 | SLC25A46 | 91137 | 9 | 1 | 60 | |
| GSE54994 | SLC25A46 | 91137 | 1 | 17 | 35 | |
| GSE60625 | SLC25A46 | 91137 | 0 | 0 | 11 | |
| GSE74703 | SLC25A46 | 91137 | 2 | 6 | 28 | |
| GSE74704 | SLC25A46 | 91137 | 1 | 7 | 12 | |
| TCGA | SLC25A46 | 91137 | 2 | 41 | 53 |
Total number of gains: 20; Total number of losses: 155; Total Number of normals: 313.
Somatic mutations of SLC25A46:
Generating mutation plots.
Highly correlated genes for SLC25A46:
Showing top 20/835 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC25A46 | ZDHHC21 | 0.797652 | 3 | 0 | 3 |
| SLC25A46 | SUGT1 | 0.78179 | 3 | 0 | 3 |
| SLC25A46 | KCTD6 | 0.780741 | 3 | 0 | 3 |
| SLC25A46 | CEP44 | 0.759745 | 3 | 0 | 3 |
| SLC25A46 | CLTB | 0.75531 | 6 | 0 | 6 |
| SLC25A46 | TTC39B | 0.736765 | 4 | 0 | 3 |
| SLC25A46 | APEH | 0.736325 | 5 | 0 | 4 |
| SLC25A46 | NPAT | 0.735086 | 3 | 0 | 3 |
| SLC25A46 | WDR11 | 0.734171 | 3 | 0 | 3 |
| SLC25A46 | LYSMD3 | 0.72951 | 7 | 0 | 7 |
| SLC25A46 | FAM174A | 0.727695 | 6 | 0 | 5 |
| SLC25A46 | FAM83D | 0.721066 | 3 | 0 | 3 |
| SLC25A46 | IRAK2 | 0.718164 | 3 | 0 | 3 |
| SLC25A46 | EIF1AY | 0.714262 | 3 | 0 | 3 |
| SLC25A46 | ETF1 | 0.713765 | 7 | 0 | 6 |
| SLC25A46 | PRELID1 | 0.713384 | 3 | 0 | 3 |
| SLC25A46 | APOOL | 0.712261 | 3 | 0 | 3 |
| SLC25A46 | ARL5A | 0.711946 | 3 | 0 | 3 |
| SLC25A46 | E2F8 | 0.711324 | 3 | 0 | 3 |
| SLC25A46 | KDM3A | 0.711015 | 3 | 0 | 3 |
For details and further investigation, click here
