| Full name: natriuretic peptide C | Alias Symbol: CNP | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 4880 | HGNC ID: HGNC:7941 | Ensembl Gene: ENSG00000163273 | OMIM ID: 600296 |
| Drug and gene relationship at DGIdb | |||
Expression of NPPC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPPC | 4880 | 221348_at | -0.3854 | 0.3251 | |
| GSE20347 | NPPC | 4880 | 221348_at | -0.1893 | 0.0015 | |
| GSE23400 | NPPC | 4880 | 221348_at | -0.1287 | 0.0001 | |
| GSE26886 | NPPC | 4880 | 221348_at | 0.4302 | 0.0003 | |
| GSE29001 | NPPC | 4880 | 221348_at | -0.1449 | 0.1001 | |
| GSE38129 | NPPC | 4880 | 221348_at | -0.2672 | 0.0001 | |
| GSE45670 | NPPC | 4880 | 221348_at | -0.5175 | 0.0060 | |
| GSE53622 | NPPC | 4880 | 42696 | -1.2077 | 0.0000 | |
| GSE53624 | NPPC | 4880 | 42696 | -0.7316 | 0.0000 | |
| GSE63941 | NPPC | 4880 | 221348_at | 0.0847 | 0.7206 | |
| GSE77861 | NPPC | 4880 | 221348_at | -0.0306 | 0.8317 | |
| GSE97050 | NPPC | 4880 | A_23_P301942 | -0.2754 | 0.2830 | |
| SRP133303 | NPPC | 4880 | RNAseq | -1.7895 | 0.0026 | |
| SRP159526 | NPPC | 4880 | RNAseq | -2.2837 | 0.0002 | |
| SRP219564 | NPPC | 4880 | RNAseq | -1.1941 | 0.3529 | |
| TCGA | NPPC | 4880 | RNAseq | 0.0652 | 0.9354 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by NPPC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPPC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPPC | 4880 | 1 | 12 | 17 | |
| GSE20123 | NPPC | 4880 | 1 | 12 | 17 | |
| GSE43470 | NPPC | 4880 | 1 | 8 | 34 | |
| GSE46452 | NPPC | 4880 | 0 | 5 | 54 | |
| GSE47630 | NPPC | 4880 | 4 | 5 | 31 | |
| GSE54993 | NPPC | 4880 | 2 | 2 | 66 | |
| GSE54994 | NPPC | 4880 | 6 | 11 | 36 | |
| GSE60625 | NPPC | 4880 | 0 | 3 | 8 | |
| GSE74703 | NPPC | 4880 | 1 | 6 | 29 | |
| GSE74704 | NPPC | 4880 | 1 | 5 | 14 | |
| TCGA | NPPC | 4880 | 12 | 27 | 57 |
Total number of gains: 29; Total number of losses: 96; Total Number of normals: 363.
Somatic mutations of NPPC:
Generating mutation plots.
Highly correlated genes for NPPC:
Showing top 20/200 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPPC | CCDC130 | 0.754832 | 3 | 0 | 3 |
| NPPC | CDH23 | 0.729928 | 3 | 0 | 3 |
| NPPC | MYH13 | 0.720069 | 3 | 0 | 3 |
| NPPC | BAHCC1 | 0.706264 | 3 | 0 | 3 |
| NPPC | OSBPL5 | 0.701428 | 3 | 0 | 3 |
| NPPC | PROCA1 | 0.693059 | 3 | 0 | 3 |
| NPPC | DPM3 | 0.688018 | 3 | 0 | 3 |
| NPPC | MOGAT3 | 0.687386 | 3 | 0 | 3 |
| NPPC | RASL10B | 0.68537 | 4 | 0 | 3 |
| NPPC | VAMP4 | 0.680705 | 3 | 0 | 3 |
| NPPC | USHBP1 | 0.672564 | 3 | 0 | 3 |
| NPPC | THRSP | 0.669026 | 3 | 0 | 3 |
| NPPC | CPAMD8 | 0.666211 | 3 | 0 | 3 |
| NPPC | ARMC5 | 0.659776 | 3 | 0 | 3 |
| NPPC | ADRA2C | 0.657013 | 4 | 0 | 3 |
| NPPC | TMPRSS5 | 0.65205 | 3 | 0 | 3 |
| NPPC | SHC2 | 0.643156 | 5 | 0 | 4 |
| NPPC | ZNF446 | 0.643143 | 4 | 0 | 4 |
| NPPC | TERT | 0.639487 | 4 | 0 | 3 |
| NPPC | SCNN1D | 0.63868 | 4 | 0 | 3 |
For details and further investigation, click here
