| Full name: glutathione synthetase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 2937 | HGNC ID: HGNC:4624 | Ensembl Gene: ENSG00000100983 | OMIM ID: 601002 |
| Drug and gene relationship at DGIdb | |||
Expression of GSS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GSS | 2937 | 211630_s_at | 0.5680 | 0.0591 | |
| GSE20347 | GSS | 2937 | 201415_at | 0.4685 | 0.0009 | |
| GSE23400 | GSS | 2937 | 201415_at | 0.4230 | 0.0000 | |
| GSE26886 | GSS | 2937 | 201415_at | 0.1180 | 0.5972 | |
| GSE29001 | GSS | 2937 | 201415_at | 0.5795 | 0.0052 | |
| GSE38129 | GSS | 2937 | 201415_at | 0.6314 | 0.0000 | |
| GSE45670 | GSS | 2937 | 201415_at | 0.5765 | 0.0000 | |
| GSE53622 | GSS | 2937 | 55532 | 0.3401 | 0.0001 | |
| GSE53624 | GSS | 2937 | 55532 | 0.3918 | 0.0000 | |
| GSE63941 | GSS | 2937 | 201415_at | 0.2501 | 0.5553 | |
| GSE77861 | GSS | 2937 | 211630_s_at | 0.2750 | 0.2789 | |
| GSE97050 | GSS | 2937 | A_23_P210920 | 0.3464 | 0.4516 | |
| SRP007169 | GSS | 2937 | RNAseq | 0.0725 | 0.8314 | |
| SRP008496 | GSS | 2937 | RNAseq | 0.0462 | 0.8289 | |
| SRP064894 | GSS | 2937 | RNAseq | 0.9792 | 0.0001 | |
| SRP133303 | GSS | 2937 | RNAseq | 0.2992 | 0.0731 | |
| SRP159526 | GSS | 2937 | RNAseq | 0.2387 | 0.3486 | |
| SRP193095 | GSS | 2937 | RNAseq | 0.0069 | 0.9554 | |
| SRP219564 | GSS | 2937 | RNAseq | 0.4804 | 0.0648 | |
| TCGA | GSS | 2937 | RNAseq | 0.2042 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GSS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GSS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GSS | 2937 | 16 | 0 | 14 | |
| GSE20123 | GSS | 2937 | 16 | 0 | 14 | |
| GSE43470 | GSS | 2937 | 12 | 0 | 31 | |
| GSE46452 | GSS | 2937 | 29 | 0 | 30 | |
| GSE47630 | GSS | 2937 | 24 | 1 | 15 | |
| GSE54993 | GSS | 2937 | 0 | 18 | 52 | |
| GSE54994 | GSS | 2937 | 25 | 0 | 28 | |
| GSE60625 | GSS | 2937 | 0 | 0 | 11 | |
| GSE74703 | GSS | 2937 | 11 | 0 | 25 | |
| GSE74704 | GSS | 2937 | 11 | 0 | 9 | |
| TCGA | GSS | 2937 | 49 | 3 | 44 |
Total number of gains: 193; Total number of losses: 22; Total Number of normals: 273.
Somatic mutations of GSS:
Generating mutation plots.
Highly correlated genes for GSS:
Showing top 20/1338 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GSS | NRIP1 | 0.787636 | 3 | 0 | 3 |
| GSS | TP53RK | 0.733624 | 3 | 0 | 3 |
| GSS | ARL6IP6 | 0.729116 | 3 | 0 | 3 |
| GSS | TMEM189 | 0.72508 | 3 | 0 | 3 |
| GSS | INO80B | 0.72108 | 4 | 0 | 3 |
| GSS | MGAT4B | 0.719383 | 3 | 0 | 3 |
| GSS | TMEM167A | 0.718188 | 3 | 0 | 3 |
| GSS | ADRM1 | 0.714937 | 9 | 0 | 9 |
| GSS | TRMT6 | 0.711997 | 4 | 0 | 4 |
| GSS | CXCL16 | 0.710041 | 4 | 0 | 4 |
| GSS | EME1 | 0.707659 | 4 | 0 | 3 |
| GSS | ARHGEF19 | 0.703856 | 4 | 0 | 3 |
| GSS | SPAST | 0.703441 | 3 | 0 | 3 |
| GSS | SMAD1 | 0.702798 | 3 | 0 | 3 |
| GSS | TGFB1 | 0.697991 | 5 | 0 | 4 |
| GSS | C8orf76 | 0.697209 | 5 | 0 | 4 |
| GSS | LGALS8 | 0.695734 | 3 | 0 | 3 |
| GSS | A1BG | 0.69568 | 3 | 0 | 3 |
| GSS | FIGNL1 | 0.686574 | 4 | 0 | 3 |
| GSS | LRRC8B | 0.685711 | 4 | 0 | 3 |
For details and further investigation, click here
