| Full name: NUAK family kinase 1 | Alias Symbol: ARK5|KIAA0537|NuaK1 | ||
| Type: protein-coding gene | Cytoband: 12q23.3 | ||
| Entrez ID: 9891 | HGNC ID: HGNC:14311 | Ensembl Gene: ENSG00000074590 | OMIM ID: 608130 |
| Drug and gene relationship at DGIdb | |||
Expression of NUAK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NUAK1 | 9891 | 204589_at | 0.7517 | 0.1907 | |
| GSE20347 | NUAK1 | 9891 | 204589_at | 1.6153 | 0.0000 | |
| GSE23400 | NUAK1 | 9891 | 204589_at | 0.8087 | 0.0000 | |
| GSE26886 | NUAK1 | 9891 | 204589_at | 2.7963 | 0.0000 | |
| GSE29001 | NUAK1 | 9891 | 204589_at | 1.4640 | 0.0040 | |
| GSE38129 | NUAK1 | 9891 | 204589_at | 1.4837 | 0.0000 | |
| GSE45670 | NUAK1 | 9891 | 204589_at | 0.1691 | 0.7536 | |
| GSE53622 | NUAK1 | 9891 | 93120 | 1.4310 | 0.0000 | |
| GSE53624 | NUAK1 | 9891 | 93120 | 1.8068 | 0.0000 | |
| GSE63941 | NUAK1 | 9891 | 204589_at | 0.1100 | 0.9097 | |
| GSE77861 | NUAK1 | 9891 | 204589_at | 1.2707 | 0.0411 | |
| GSE97050 | NUAK1 | 9891 | A_23_P348257 | 0.2388 | 0.4452 | |
| SRP007169 | NUAK1 | 9891 | RNAseq | 2.2257 | 0.0000 | |
| SRP008496 | NUAK1 | 9891 | RNAseq | 3.1576 | 0.0000 | |
| SRP064894 | NUAK1 | 9891 | RNAseq | 1.6017 | 0.0000 | |
| SRP133303 | NUAK1 | 9891 | RNAseq | 1.0528 | 0.0002 | |
| SRP159526 | NUAK1 | 9891 | RNAseq | 1.5214 | 0.0000 | |
| SRP193095 | NUAK1 | 9891 | RNAseq | 1.9709 | 0.0000 | |
| SRP219564 | NUAK1 | 9891 | RNAseq | 1.1618 | 0.0360 | |
| TCGA | NUAK1 | 9891 | RNAseq | 0.2131 | 0.0797 |
Upregulated datasets: 14; Downregulated datasets: 0.
Survival by NUAK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NUAK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NUAK1 | 9891 | 5 | 2 | 23 | |
| GSE20123 | NUAK1 | 9891 | 5 | 2 | 23 | |
| GSE43470 | NUAK1 | 9891 | 2 | 1 | 40 | |
| GSE46452 | NUAK1 | 9891 | 9 | 1 | 49 | |
| GSE47630 | NUAK1 | 9891 | 9 | 1 | 30 | |
| GSE54993 | NUAK1 | 9891 | 0 | 5 | 65 | |
| GSE54994 | NUAK1 | 9891 | 4 | 2 | 47 | |
| GSE60625 | NUAK1 | 9891 | 0 | 0 | 11 | |
| GSE74703 | NUAK1 | 9891 | 2 | 0 | 34 | |
| GSE74704 | NUAK1 | 9891 | 2 | 2 | 16 | |
| TCGA | NUAK1 | 9891 | 20 | 10 | 66 |
Total number of gains: 58; Total number of losses: 26; Total Number of normals: 404.
Somatic mutations of NUAK1:
Generating mutation plots.
Highly correlated genes for NUAK1:
Showing top 20/1517 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NUAK1 | HAS3 | 0.83341 | 3 | 0 | 3 |
| NUAK1 | ALKBH6 | 0.81237 | 3 | 0 | 3 |
| NUAK1 | FADS1 | 0.781188 | 3 | 0 | 3 |
| NUAK1 | PXDN | 0.7706 | 12 | 0 | 11 |
| NUAK1 | TMEM263 | 0.739328 | 5 | 0 | 5 |
| NUAK1 | CDH11 | 0.739167 | 12 | 0 | 12 |
| NUAK1 | VCAN | 0.734269 | 12 | 0 | 12 |
| NUAK1 | DERL2 | 0.732729 | 3 | 0 | 3 |
| NUAK1 | SPARC | 0.727286 | 12 | 0 | 11 |
| NUAK1 | COL5A2 | 0.725714 | 12 | 0 | 11 |
| NUAK1 | NPRL3 | 0.724439 | 3 | 0 | 3 |
| NUAK1 | SHISA2 | 0.72175 | 6 | 0 | 6 |
| NUAK1 | HTRA1 | 0.719715 | 12 | 0 | 11 |
| NUAK1 | COL5A1 | 0.716949 | 13 | 0 | 12 |
| NUAK1 | CD276 | 0.716115 | 4 | 0 | 4 |
| NUAK1 | HIP1 | 0.716112 | 9 | 0 | 9 |
| NUAK1 | FKBP7 | 0.714768 | 6 | 0 | 5 |
| NUAK1 | TRAM2 | 0.714036 | 12 | 0 | 11 |
| NUAK1 | RILPL1 | 0.710249 | 4 | 0 | 3 |
| NUAK1 | EFTUD2 | 0.710218 | 5 | 0 | 5 |
For details and further investigation, click here
