| Full name: NUMB endocytic adaptor protein | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 8650 | HGNC ID: HGNC:8060 | Ensembl Gene: | OMIM ID: 603728 |
NUMB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of NUMB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NUMB | 8650 | 230462_at | 0.2173 | 0.8163 | |
| GSE26886 | NUMB | 8650 | 230462_at | -0.0334 | 0.8580 | |
| GSE45670 | NUMB | 8650 | 230462_at | 0.0586 | 0.7785 | |
| GSE53622 | NUMB | 8650 | 11994 | -0.1247 | 0.1193 | |
| GSE53624 | NUMB | 8650 | 11994 | -0.2415 | 0.0000 | |
| GSE63941 | NUMB | 8650 | 230462_at | -1.1887 | 0.0001 | |
| GSE77861 | NUMB | 8650 | 230462_at | 0.0686 | 0.7626 | |
| GSE97050 | NUMB | 8650 | A_23_P88381 | -0.1812 | 0.3734 | |
| SRP007169 | NUMB | 8650 | RNAseq | 0.3711 | 0.3827 | |
| SRP008496 | NUMB | 8650 | RNAseq | 0.1460 | 0.6448 | |
| SRP064894 | NUMB | 8650 | RNAseq | 0.0079 | 0.9633 | |
| SRP133303 | NUMB | 8650 | RNAseq | 0.1361 | 0.4522 | |
| SRP159526 | NUMB | 8650 | RNAseq | -0.6809 | 0.0058 | |
| SRP193095 | NUMB | 8650 | RNAseq | -0.1634 | 0.2136 | |
| SRP219564 | NUMB | 8650 | RNAseq | -0.2989 | 0.2186 | |
| TCGA | NUMB | 8650 | RNAseq | -0.0676 | 0.1325 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NUMB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NUMB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NUMB | 8650 | 8 | 2 | 20 | |
| GSE20123 | NUMB | 8650 | 8 | 2 | 20 | |
| GSE43470 | NUMB | 8650 | 8 | 3 | 32 | |
| GSE46452 | NUMB | 8650 | 16 | 3 | 40 | |
| GSE47630 | NUMB | 8650 | 11 | 8 | 21 | |
| GSE54993 | NUMB | 8650 | 3 | 8 | 59 | |
| GSE54994 | NUMB | 8650 | 19 | 4 | 30 | |
| GSE60625 | NUMB | 8650 | 0 | 2 | 9 | |
| GSE74703 | NUMB | 8650 | 7 | 3 | 26 | |
| GSE74704 | NUMB | 8650 | 3 | 2 | 15 | |
| TCGA | NUMB | 8650 | 31 | 16 | 49 |
Total number of gains: 114; Total number of losses: 53; Total Number of normals: 321.
Somatic mutations of NUMB:
Generating mutation plots.
Highly correlated genes for NUMB:
Showing top 20/25 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NUMB | ANKHD1 | 0.64869 | 3 | 0 | 3 |
| NUMB | EFHC1 | 0.621303 | 3 | 0 | 3 |
| NUMB | PTPN21 | 0.606299 | 4 | 0 | 4 |
| NUMB | ZNF398 | 0.596154 | 3 | 0 | 3 |
| NUMB | MARK3 | 0.589687 | 7 | 0 | 4 |
| NUMB | SEC23A | 0.588469 | 4 | 0 | 3 |
| NUMB | GPATCH2L | 0.585853 | 3 | 0 | 3 |
| NUMB | RBPJ | 0.583989 | 3 | 0 | 3 |
| NUMB | MAN2A1 | 0.549005 | 4 | 0 | 3 |
| NUMB | GRIA3 | 0.547826 | 3 | 0 | 3 |
| NUMB | FLII | 0.538333 | 3 | 0 | 3 |
| NUMB | DAAM1 | 0.535147 | 5 | 0 | 4 |
| NUMB | P4HA1 | 0.532846 | 4 | 0 | 3 |
| NUMB | INTU | 0.530186 | 4 | 0 | 3 |
| NUMB | GPHN | 0.526299 | 5 | 0 | 3 |
| NUMB | PPP2R5E | 0.521559 | 5 | 0 | 3 |
| NUMB | GOLGA5 | 0.520764 | 6 | 0 | 4 |
| NUMB | KLF7 | 0.518905 | 4 | 0 | 3 |
| NUMB | PEAR1 | 0.517896 | 5 | 0 | 3 |
| NUMB | ZFYVE21 | 0.511436 | 5 | 0 | 3 |
For details and further investigation, click here
