| Full name: prolyl 4-hydroxylase subunit alpha 1 | Alias Symbol: C-P4Halpha(I) | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 5033 | HGNC ID: HGNC:8546 | Ensembl Gene: ENSG00000122884 | OMIM ID: 176710 |
| Drug and gene relationship at DGIdb | |||
Expression of P4HA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | P4HA1 | 5033 | 207543_s_at | 0.9294 | 0.2055 | |
| GSE20347 | P4HA1 | 5033 | 207543_s_at | 1.4012 | 0.0000 | |
| GSE23400 | P4HA1 | 5033 | 207543_s_at | 0.9444 | 0.0000 | |
| GSE26886 | P4HA1 | 5033 | 207543_s_at | 0.9278 | 0.0000 | |
| GSE29001 | P4HA1 | 5033 | 207543_s_at | 0.9461 | 0.0144 | |
| GSE38129 | P4HA1 | 5033 | 207543_s_at | 1.3637 | 0.0000 | |
| GSE45670 | P4HA1 | 5033 | 207543_s_at | 0.6215 | 0.1034 | |
| GSE53622 | P4HA1 | 5033 | 37226 | 1.4967 | 0.0000 | |
| GSE53624 | P4HA1 | 5033 | 123210 | 1.7857 | 0.0000 | |
| GSE63941 | P4HA1 | 5033 | 207543_s_at | -1.1578 | 0.1161 | |
| GSE77861 | P4HA1 | 5033 | 207543_s_at | 0.6768 | 0.3033 | |
| GSE97050 | P4HA1 | 5033 | A_33_P3214481 | 0.5876 | 0.2564 | |
| SRP007169 | P4HA1 | 5033 | RNAseq | 1.8969 | 0.0000 | |
| SRP008496 | P4HA1 | 5033 | RNAseq | 1.9837 | 0.0000 | |
| SRP064894 | P4HA1 | 5033 | RNAseq | 1.5852 | 0.0000 | |
| SRP133303 | P4HA1 | 5033 | RNAseq | 2.1925 | 0.0000 | |
| SRP159526 | P4HA1 | 5033 | RNAseq | 1.3776 | 0.0002 | |
| SRP193095 | P4HA1 | 5033 | RNAseq | 1.3850 | 0.0000 | |
| SRP219564 | P4HA1 | 5033 | RNAseq | 1.1971 | 0.0023 | |
| TCGA | P4HA1 | 5033 | RNAseq | 0.2149 | 0.0115 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by P4HA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of P4HA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | P4HA1 | 5033 | 3 | 4 | 23 | |
| GSE20123 | P4HA1 | 5033 | 3 | 3 | 24 | |
| GSE43470 | P4HA1 | 5033 | 1 | 8 | 34 | |
| GSE46452 | P4HA1 | 5033 | 0 | 11 | 48 | |
| GSE47630 | P4HA1 | 5033 | 2 | 14 | 24 | |
| GSE54993 | P4HA1 | 5033 | 7 | 0 | 63 | |
| GSE54994 | P4HA1 | 5033 | 2 | 11 | 40 | |
| GSE60625 | P4HA1 | 5033 | 0 | 0 | 11 | |
| GSE74703 | P4HA1 | 5033 | 1 | 5 | 30 | |
| GSE74704 | P4HA1 | 5033 | 1 | 1 | 18 | |
| TCGA | P4HA1 | 5033 | 11 | 23 | 62 |
Total number of gains: 31; Total number of losses: 80; Total Number of normals: 377.
Somatic mutations of P4HA1:
Generating mutation plots.
Highly correlated genes for P4HA1:
Showing top 20/1540 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| P4HA1 | CCDC127 | 0.807062 | 3 | 0 | 3 |
| P4HA1 | GNG10 | 0.772353 | 3 | 0 | 3 |
| P4HA1 | FAM89A | 0.762235 | 3 | 0 | 3 |
| P4HA1 | MFAP2 | 0.747104 | 11 | 0 | 11 |
| P4HA1 | ARL13B | 0.745069 | 3 | 0 | 3 |
| P4HA1 | PLOD1 | 0.742242 | 12 | 0 | 12 |
| P4HA1 | LOXL2 | 0.739674 | 12 | 0 | 12 |
| P4HA1 | PDE7A | 0.733969 | 6 | 0 | 6 |
| P4HA1 | DVL3 | 0.731469 | 5 | 0 | 5 |
| P4HA1 | FADS1 | 0.729021 | 3 | 0 | 3 |
| P4HA1 | INHBA | 0.728209 | 11 | 0 | 11 |
| P4HA1 | DHRS7 | 0.727783 | 3 | 0 | 3 |
| P4HA1 | SPON2 | 0.727582 | 3 | 0 | 3 |
| P4HA1 | NEK6 | 0.723138 | 6 | 0 | 6 |
| P4HA1 | ALPK2 | 0.721609 | 3 | 0 | 3 |
| P4HA1 | HIC1 | 0.720924 | 3 | 0 | 3 |
| P4HA1 | PLOD3 | 0.718931 | 11 | 0 | 11 |
| P4HA1 | CCDC24 | 0.710747 | 3 | 0 | 3 |
| P4HA1 | CPXM1 | 0.707203 | 4 | 0 | 4 |
| P4HA1 | WDR54 | 0.701434 | 8 | 0 | 7 |
For details and further investigation, click here
