| Full name: zinc finger FYVE-type containing 21 | Alias Symbol: MGC2550|ZF21 | ||
| Type: protein-coding gene | Cytoband: 14q32.33 | ||
| Entrez ID: 79038 | HGNC ID: HGNC:20760 | Ensembl Gene: ENSG00000100711 | OMIM ID: 613504 |
| Drug and gene relationship at DGIdb | |||
Expression of ZFYVE21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZFYVE21 | 79038 | 224445_s_at | -0.5630 | 0.3147 | |
| GSE20347 | ZFYVE21 | 79038 | 219929_s_at | -1.1060 | 0.0000 | |
| GSE23400 | ZFYVE21 | 79038 | 219929_s_at | -0.4954 | 0.0000 | |
| GSE26886 | ZFYVE21 | 79038 | 224445_s_at | -1.3475 | 0.0000 | |
| GSE29001 | ZFYVE21 | 79038 | 219929_s_at | -0.2207 | 0.3012 | |
| GSE38129 | ZFYVE21 | 79038 | 219929_s_at | -0.8550 | 0.0004 | |
| GSE45670 | ZFYVE21 | 79038 | 224445_s_at | -0.6073 | 0.0000 | |
| GSE53622 | ZFYVE21 | 79038 | 23226 | -0.6760 | 0.0000 | |
| GSE53624 | ZFYVE21 | 79038 | 23226 | -0.6857 | 0.0000 | |
| GSE63941 | ZFYVE21 | 79038 | 224445_s_at | -0.8246 | 0.1337 | |
| GSE77861 | ZFYVE21 | 79038 | 224445_s_at | -0.5762 | 0.0578 | |
| GSE97050 | ZFYVE21 | 79038 | A_23_P14273 | -0.5135 | 0.1453 | |
| SRP007169 | ZFYVE21 | 79038 | RNAseq | -1.1823 | 0.0024 | |
| SRP008496 | ZFYVE21 | 79038 | RNAseq | -1.0034 | 0.0001 | |
| SRP064894 | ZFYVE21 | 79038 | RNAseq | -0.6025 | 0.0003 | |
| SRP133303 | ZFYVE21 | 79038 | RNAseq | -0.7209 | 0.0000 | |
| SRP159526 | ZFYVE21 | 79038 | RNAseq | -0.8521 | 0.0232 | |
| SRP193095 | ZFYVE21 | 79038 | RNAseq | -0.9782 | 0.0000 | |
| SRP219564 | ZFYVE21 | 79038 | RNAseq | -0.4406 | 0.1107 | |
| TCGA | ZFYVE21 | 79038 | RNAseq | -0.1223 | 0.0368 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by ZFYVE21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZFYVE21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZFYVE21 | 79038 | 12 | 3 | 15 | |
| GSE20123 | ZFYVE21 | 79038 | 11 | 2 | 17 | |
| GSE43470 | ZFYVE21 | 79038 | 6 | 4 | 33 | |
| GSE46452 | ZFYVE21 | 79038 | 18 | 4 | 37 | |
| GSE47630 | ZFYVE21 | 79038 | 10 | 8 | 22 | |
| GSE54993 | ZFYVE21 | 79038 | 3 | 8 | 59 | |
| GSE54994 | ZFYVE21 | 79038 | 21 | 4 | 28 | |
| GSE60625 | ZFYVE21 | 79038 | 0 | 2 | 9 | |
| GSE74703 | ZFYVE21 | 79038 | 5 | 3 | 28 | |
| GSE74704 | ZFYVE21 | 79038 | 5 | 2 | 13 | |
| TCGA | ZFYVE21 | 79038 | 29 | 22 | 45 |
Total number of gains: 120; Total number of losses: 62; Total Number of normals: 306.
Somatic mutations of ZFYVE21:
Generating mutation plots.
Highly correlated genes for ZFYVE21:
Showing top 20/1288 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZFYVE21 | CCDC66 | 0.809793 | 3 | 0 | 3 |
| ZFYVE21 | LMNA | 0.732474 | 3 | 0 | 3 |
| ZFYVE21 | UBR3 | 0.715508 | 3 | 0 | 3 |
| ZFYVE21 | ZFYVE1 | 0.714792 | 7 | 0 | 7 |
| ZFYVE21 | ZFAND2B | 0.706033 | 6 | 0 | 6 |
| ZFYVE21 | TMEM159 | 0.704221 | 8 | 0 | 8 |
| ZFYVE21 | CLEC3B | 0.704131 | 3 | 0 | 3 |
| ZFYVE21 | BRK1 | 0.695343 | 6 | 0 | 5 |
| ZFYVE21 | SRRM1 | 0.692112 | 3 | 0 | 3 |
| ZFYVE21 | GGA3 | 0.690041 | 4 | 0 | 3 |
| ZFYVE21 | KLHL20 | 0.687934 | 4 | 0 | 3 |
| ZFYVE21 | NFIA | 0.685242 | 8 | 0 | 7 |
| ZFYVE21 | C6orf89 | 0.683149 | 3 | 0 | 3 |
| ZFYVE21 | TMEM120A | 0.682554 | 6 | 0 | 6 |
| ZFYVE21 | TMEM139 | 0.680722 | 4 | 0 | 4 |
| ZFYVE21 | EIF4E3 | 0.677878 | 7 | 0 | 7 |
| ZFYVE21 | LEPROT | 0.674633 | 4 | 0 | 3 |
| ZFYVE21 | SLC46A2 | 0.672738 | 6 | 0 | 6 |
| ZFYVE21 | ZNF654 | 0.671954 | 7 | 0 | 6 |
| ZFYVE21 | PITPNM3 | 0.671863 | 6 | 0 | 5 |
For details and further investigation, click here
